Searchable abstracts of presentations at key conferences in endocrinology

ea0032p156 | Calcium and Vitamin D metabolism | ECE2013

MSIA–SRM assay for parathyroid hormone and vitamin D binding protein: correlation with clinical immunoassay methods and application to clinical samples

Moniz Caje , Couchman Lewis , Krastins Bryan , Lopez Mary , Prakash Amol , Sarracino David , Vogelsang Mary , Peterman Scott , Vadali Gouri , Robinson Sarah

Parathyroid hormone is involved in calcium homeostasis through interactions with vitamin D. Because intact and truncated forms of PTH vary in their biological activity, assays that can accurately quantify the ratio of intact hormone to its fragments are of increasing significance in the diagnosis of endocrine, renal and bone diseases. Vitamin D and its metabolites circulate tightly bound to vitamin D-binding protein (DBP). Because DBP concentrations are altered in pregnancy, l...