Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps2-10-88 | Nodules & Cancer | ETA2022

Neoadjuvant effects of apatinib in progressive, metastatic differentiated thyroid cancer (DTC)

Shi Liang , You Qinqin , Wang Jun , Wang Hanjin , Li Shaohua , Tian Rui , Yao Xiaocheng , Wu Wenyu , Zhang Lele , Wang Feng , Lin Yansong , LI Shuren

Purpose: Recently, apatinib, an orally anti-angiogenic tyrosine kinase inhibitor (TKI) is reported to be useful for treatment of progressive RAIR-DIC. The aim of this study was to evaluate the effect of apatinib and the combination therapy with radioactive iodine (RAI) in patients with progressive metastatic DTC.Methods: Five patients (all female mean age 62 ± 8 years, ranged from 51 to 69 years) with progressive distant metastatic DTC (dmDTC) after t...

ea0070aep281 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The MAFA gene mutation responsible for familial insulinomatosis and diabetes impairs insulin secretion and results in downregulation of critical cell cycle regulators

Iacovazzo Donato , Thong Lim Chung , Quezado Rosana , Drummond Juliana , Antonio de Sousa Barros Fernando , Cuenco Joyceline , Brändle Michael , Walker Emily , Guo Min , Collier David , Khan Faraz , Wang Jun , Tan Tricia , Ellard Sian , Stein Roland , Korbonits Marta

The islet-enriched transcription factor MAFA regulates the expression of genes critical to beta cell function and insulin secretion. We previously described anovel MAFA mutation (c.191C > T, p.S64F) causing familial insulinomatosis and diabetes mellitus, with male carriers more often developing diabetes and females more prone to insulinomatosis. The exact molecular mechanisms underlying these phenotypes are unclear. In this study, we assessed glucose metabolism an...