Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc13.6 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Machine Learning models for the accurate prediction of malignant pheochromocytomas and paragangliomas

Pamporaki Christina , Berends Annika MA , Filippatos Angelos , Prodanov Tamara , Meuter Leah , Prejbisz Aleksander , Beuschlein Felix , Fassnacht Martin , Timmers Henri , Noelting Svenja , Abhyankar Kaushik Ganesh , Contsantinescu Georgiana , Kunath Carola , Wang Katharina , Remde Hanna , Januszewicz Andrzej , Robledo Mercedes , Lenders Jacques , Kerstens Michiel , Pacak Karel , Eisenhofer Graeme

Introduction: Pheochromocytomas and paragangliomas (PPGLs) exhibit an up to 20% malignancy rate. Various clinical, genetic, and pathological features have been proposed as predictors of malignancy. However, until present there are no robust indices to reliably predict metastatic PPGLs.Aim: The aim of the present study was to prospectively validate the value of methoxytyramine as risk marker of metastatic disease and establish a machine learning (ML) mode...

ea0099ep223 | Endocrine-Related Cancer | ECE2024

Opposing effects of cannabidiol (CBD) on pheochromocytoma/paraganglioma and neuroendocrine tumor cell lines and individual patient-derived primary cultures

Wang Katharina , Schober Laura , Fischer Alessa , Bechmann Nicole , Maurer Julian , Peischer Lea , Reul Astrid , Hantel Constanze , Reincke Martin , Beuschlein Felix , Robledo Mercedes , Mohr Hermine , Pellegata Natalia , Schilbach Katharina , Knosel Thomas , Ilmer Matthias , Angele Martin , Kroiss Matthias , Maccio Umberto , Broglie-Dappen Martina , Vetter Diana , Lehmann Kuno , Pacak Karel , Grossman Ashley , Auernhammer Christoph , Zitzmann Kathrin , Nolting Svenja

The recreational use of cannabis is becoming more widespread since many countries, including parts of Europe, are currently discussing legalisation. Moreover, the medical use of cannabinoids is already established and has many indications such as multiple sclerosis-induced spasticity or supportive therapy in the case of tumour-associated pain or loss of weight or appetite. However, the effects of cannabinoids on tumour growth still remain largely unexplored in many tumour enti...