Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc9.4 | Reproduction | ECE2014

Kisspeptin – a novel physiological trigger for oocyte maturation in IVF treatment

Abbara Ali , Jayasena Channa , Comninos Alexander , Nijher Monica , Christopoulos Georgios , Narayanaswamy Shakunthala , Izzi-Engbeaya Chioma , Sridharan Mathini , Mason Alexina , Warwick Jane , Ashby Deborah , Ghatei Mohammad , Bloom Stephen , Carby Anna , Trew Geoffrey , Dhillo Waljit

Background: In vitro fertilisation (IVF) is an effective treatment for infertility, but can cause the ovarian hyper-stimulation syndrome (OHSS), which is associated with serous effusions, circulatory collapse, and even death. The use of human chorionic gonadotrophin (hCG) stimulates oocyte maturation during IVF, but is also the major cause of OHSS. The hypothalamic neuropeptide kisspeptin stimulates endogenous LH secretion in a GnRH-dependent manner. A more physiologi...