Searchable abstracts of presentations at key conferences in endocrinology

ea0013s73 | Nuclear hormone receptor-chromatin interactions: new approaches and insight into dynamics | SFEBES2007

Dynamics of nuclear receptor interactions on chromatin

Hager Gordon , Johnson Thomas , Schiltz R Louis , Wiench Malgorzata , Stavreva Diana , Voss Ty , Sung Myong-Hee , John Sam

In response to hormone activation of the glucocorticoid receptor, GR responsive promoters move through a complex series of activity states, a phenomenon we term promoter progression. Genome-wide profiling of glucocorticoid receptor (GR) regulated loci reveals several classes of response, including genes that are transiently activated and genes that are transiently repressed. In contrast to the conventional paradigm of activation and repression, GR modulation of genome function...

ea0014p165 | (1) | ECE2007

RET exon 13 germline polymorphism in patients with pheochromocytomas and paragangliomas

Hasse-Lazar Kornelia , Pawlaczek Agnieszka , Krawczyk Aleksandra , Wiench Malgorzata , Oczko-Wojciechowska Malgorzata , Peczkowska Mariola , Preibisz Aleksander , Kubaszek Agata , Januszewicz Andrzej , Ziaja Jacek , Jarzab Barbara

Germinal mutations in protooncogene RET are associated with the inherited medullary thyroid carcinoma (MTC) which occurs as the sole manifestation of disease (FMTC) or, more frequently, as the part of multiple endocrine neoplasia (MEN2). The contribution of RET polymorphism to the occurrence of apparent sporadic MTCs is controversial. In our previous study we have found out that the frequency of RET 769 CTT>CTG polymorphism in patients with MTCs is not significantly higher...

ea0014p368 | (1) | ECE2007

Initiating mutations of BRAF gene in papillary thyroid carcinoma and their relation to gene expression profile

Rusinek Dagmara , Wiench Malgorzata , Oczko-Wojciechowska Malgorzata , Zebracka Jadwiga , Kowalska Malgorzata , Handkiewicz-Junak Daria , Szpak-Ulczok Sylwia , Chmielik Ewa , Czarniecka Agnieszka , Jarzab Michal , Gala Grzegorz , Gubala Elzbieta , Jarzab Barbara

Introduction: Discovery of V600E (BRAFT1799A) mutation in papillary thyroid carcinoma (PTC) widened our knowledge about mechanisms of its molecular initiation. It has been revealed that activating mutations of the BRAF kinase are much more frequent in PTC than RET rearrangements.Aim of the study: Estimation of V600E BRAF mutation frequency in PTC and analysis of differences in gene expression profile between papillary thyroid car...