Searchable abstracts of presentations at key conferences in endocrinology

ea0016pl6 | Graves’ ophthalmopathy – problems solved and new questions to be answered | ECE2008

Graves’ ophthalmopathy: problems solved and new questions to be answered

Wiersinga Wilmar M

Graves’ ophthalmopathy (GO) remains the most enigmatic presentation of thyroid autoimmunity. Although many issues regarding its pathogenesis and management have been solved, they are still outnumbered by unresolved open questions.Pathogenesis: Orbital fibroblasts (OF) have been recognized as the primary target cells of the autoimmune attack. Cytokine-induced excessive secretion of glycosaminoglycans and differentiation of a subset of OF into adipocy...

ea0022s26.2 | Adverse effects of drugs on thyroid | ECE2010

Treatment of amiodarone-induced thyrotoxicosis (AIT) type 2: a RCT

Eskes Silvia A , Wiersinga Wilmar M

Background: AIT type 2 is self-limiting in nature and therefore discontinuation of amiodarone may not be necessary; however, the feasibility of continuing amiodarone has never been tested formally. Potassium perchlorate (KClO4) may have advantage when prednisone is unsuccessful in AIT type 2, possibly due to mixed cases of types 1 and 2. KClO4 also mitigates the cytotoxic effect of desethylamiodarone on thyrocytes in vitro.Ob...