Searchable abstracts of presentations at key conferences in endocrinology

ea0021p400 | Thyroid | SFEBES2009

Selective malabsorption of thyroid hormone or selective intake?

Raghavan Rajeev , Woltersdorf Wolf , Dayan Colin

Case-1: Nineteen years old nursing student with primary hypothyroidism, despite thyroxine (T4) at 200 μg/day and subsequent trial of T4+T3, remained significantly symptomatically hypothyroid. Over 4 years worsening hypothyroidism was evident (TSH: 19.1 to >200 and fT4 2.1–6.8) despite dose/regime changes. Investigations for malabsorption: normal coeliac screen, B12, ferritin, FBC, kidney and liver function, autoimmune p...

ea0027oc3.1 | Oral Communications 3 | BSPED2011

The impact of GH deficiency (GHD) and GH treatment (GHTx) on cardiovascular risk in survivors of bone marrow transplantation with total body irradiation (BMT/TBI) in childhood

Davis Nikki , Stevens Michael , Cornish Jacqueline , Stewart Claire , Moss Andrew , Woltersdorf Wolf , Elson Ruth , Crowne Elizabeth

Introduction: Survivors of childhood BMT/TBI have increased cardiovascular morbidity and GH deficiency (GHD). We aimed to investigate the relationship between cardiovascular risk and GHD and GHTx in BMT/TBI survivors.Methods: BMT/TBI survivors (n=36) and non-BMT control subjects (n=19) were sub-divided according to GH status assessed by insulin tolerance test: i) survivors with untreated GHD (N=18,11M), ii) survivors on GHTx (N</i...

ea0023p7 | (1) | BSPED2009

Increased Hypothalamic-pituitary-adrenal axis (HPAA) activity after childhood bone marrow transplantation (BMT) with total body irradiation (TBI) results in chronic hypercortisolaemia associated with obesity

Davis Nikki , Elson Ruth , Stewart Claire , Moss Andrew , Woltersdorf Wolf , Cornish Jacqueline , Stevens Michael , Crowne Elizabeth

Introduction: Data on the impact of TBI on the HPAA are limited. This study investigates the HPAA in BMT-survivors and non-BMT controls using overnight serum cortisol profiles and midnight/9am ACTH levels.Subjects (N=35): N=14, child (7), adult (7) controls, N=21 child (7), adult (14) BMT-survivors (TBI dose 12.0-14.4Gy). None had had treatment with corticosteroids in the last year.Method: Subjects rested for 3...

ea0023p13 | (1) | BSPED2009

Reduced growth hormone secretion in children and young adults following total body irradiation (TBI) for bone marrow transplantation (BMT) in childhood

Davis Nikki , Elson Ruth , Stewart Claire , Moss Andrew , Woltersdorf Wolf , Cornish Jacqueline , Stevens Michael , Crowne Elizabeth

Introduction: Growth hormone deficiency (GHD) after cranial irradiation (CRI) is time, dose and fraction dependent. TBI (12–14.4Gy) involves low dose CRI, and skeletal irradiation causing further adverse growth effects. We present baseline data from a prospective study of GH treatment.Subjects N=25: We studied 13 BMT survivors (all had TBI, 3 also had CRI <18Gy), and 12 non-BMT subjects investigated for GHD. Both groups contained y...

ea0034oc1.1 | Young Endocrinologists prize session | SFEBES2014

The Thr92Ala substitution in deiodonase-2 is associated with increased odds of a sub-optimal IQ score in children with low-normal thyroid function

Taylor Peter , Okosieme Onyebuchi , Sayers Adrian , Northstone Kate , Draman Mohd , Stevenson Kirsty , Woltersdorf Wolf , Taylor Andrew , Pearce Elizabeth , Panicker Vijay , Ludgate Marian , Gregory John , Lazarus John , Timpson Nicholas , Channon Sue , Dayan Colin

Importance: Thyroid hormone is essential for cognitive development. The Thr92Ala substitution in deiodonase-2 appears to reduce intracellular availability of active thyroid hormone. Individuals with low-normal serum thyroid hormone levels and this substitution might have insufficient intracellular thyroid hormone for optimal cognitive development.Objective: To explore whether individuals with low thyroid hormone bioavailability – free thyroxine in t...