ea0025p146 | Diabetes, metabolism and cardiovascular | SFEBES2011
Aye Myint M
, Afolabi Paul R
, Sathyapalan T
, Wakil Ammar
, Wootton S A
, Sandeman Derek D
, Kilpatrick Eric S
, Atkin Stephen L
Background: Postprandial hypertriglyceridaemia is an independent risk factor for cardiovascular diseases. An acute rise of insulin in the fed state suppresses hormone-sensitive lipase to inhibit free fatty acids (FFAs) mobilisation from adipose tissue, and up-regulates lipoprotein lipase to increase FFAs influx to adipose tissue from chylomicrons, that is blunted in insulin resistant states. Polycystic ovary syndrome (PCOS) is associated with insulin resistance and cardiovascu...