Endocrine Abstracts

Introduction: The incidence of Type 2 Diabetes Mellitus (T2DM) is rapidly increasing within the paediatric community, prompting searches for a simple and effective screening tool. Oral glucose tolerance test (OGTT) is the gold standard but is poorly accessible in the community. HbA1c offers an alternative which can be easily performed, but cut-offs for children have been extrapolated directly from the adult American Diabetes Association (ADA) diagnostic criter...

Introduction: Congenital Adrenal Hyperplasia (CAH) is an autosomal recessive condition that causes reduced cortisol, reduced aldosterone, and increased testosterone production. Hydrocortisone is used to manage CAH in children. Current literature suggests children with CAH often have abnormal growth patterns.Aims and Methods: Data from 103 children was extracted from our centre. We investigated the effects of age, sex, ethnicity, Index of Multiple Depriva...

Background: Congenital Hyperinsulinism (CHI) is characterised by dysregulated and excess secretion of insulin leading to severe hypoglycaemia. Monitoring of glucose levels is essential in this condition as prolonged hypoglycaemia can cause life-threatening complications such as permanent neurological impairment. Interstitial glucose monitoring by continuous glucose monitoring (CGM) devices can identify nocturnal hypoglycaemia retrospectively through data analysis. Analysis can...

Background: For children with congenital hyperinsulinism (HI), detection and avoidance of hypoglycaemia is the cornerstone of clinical management and poses significant demands on families. Standard of care remains intermittent fingerprick monitoring but the lack of predictive information has resulted in continuous glucose monitoring (CGM) increasing in popularity. Accuracy is suboptimal in this group and family feedback identifies various barriers to use. We a...

Background: Adrenal Insufficiency (AI) is associated with higher-than-expected mortality in children and young people (CYP) due to the risk of adrenal crisis. The risk is minimised by effective home management, supplemented by infrequent hospital-based clinical reviews. As CYP spend most time in home and school, it is important to optimise home management to improve long-term AI outcomes.Methods: A quality improvement study was undertaken in the Manchest...

Background and objective: Neonatal hypoglycemia is common and frequently self-resolving, although rare due to congenital hyperinsulinism are associated with high risk of brain injury. The time period for neonatal hypoglycemia has been described in several studies. It is unknown if low hypoglycemia thresholds (<2.0 mmol/l) lead to missed cases of persistent hypoglycaemia. We aimed to ascertain if lower hypoglycemia threshold risked missing persistent forms of hypoglycemia i...