Searchable abstracts of presentations at key conferences in endocrinology

ea0015p185 | Endocrine tumours and neoplasia | SFEBES2008

Steroid Sulphatase (STS) gene expression and regulation in normal human ovarian surface epithelium (OSE) and epithelial ovarian cancer (EOC)

Harlow Christopher R , Wu Xuan , Ren Xia , Fegan Scott , Rae Michael , Price Deborah , Mason J Ian , Hillier Stephen G

At least 90% of human ovarian cancers originate in the OSE. Most studies indicate that EOC is oestrogen responsive. Paradoxically, ovarian cancer generally occurs after the menopause, which raises the question if oestrogen is involved, where does it come from? We hypothesise that the high circulating concentrations of conjugated (inactive) oestrogens in post-menopausal women are substrates for formation of active oestrogen in the OSE through the hydrolytic enzyme activity of S...

ea0034oc3.6 | Steroids | SFEBES2014

Targeting of lysyl oxidase by steroids to reduce peritoneal fibrosis and scarring

Harlow Christopher , Wu Xuan , van Deemter Marielle , Gardiner Fiona , Poloand Craig , Green Rebecca , Sarvi Sana , Kadler Karl , Lu Yinhui , Mason J Ian , Critchley Hilary , Hillier Stephen

Abdominal surgery and diseases such as endometriosis cause persistent abdominal adhesions leading to pelvic pain, infertility and in severe cases, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent feature. Lysyl oxidase (LOX) is a key enzyme required for crosslinking and deposition of insoluble collagen.10–12 weeks old female C57Bl/6 mice (3–10 mice per gro...

ea0070aep942 | Thyroid | ECE2020

Predictive value of free triiodothyronine within normal range on cardiovascular events in a Chinese cohort with coronary artery disease: Direct effect and mediation effect by TG

Wen Jun , Su Fei , Li Xuan , Wu Na-Qiong , Gao Ying , Liu Geng , Dong Qian , Tang Yi-Da , Li Jian-Jun , Guo Yuan-Lin

Background and aims: Coronary artery disease (CAD) plays an important role in global mortality worldwide. Risk assessment for patients with CAD through free triiodothyronine (FT3) remains unclear. Therefore, we aimed to investigate the impact of FT3 on the prognosis of patients with CAD.Methods: A total of 0 patients with CAD and available FT3 data, and without overt thyroid disease were enrolled in this study and grouped by tertiles. The primary outcome...