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ea0065p28 | Adrenal and Cardiovascular | SFEBES2019

Recalibration of thinking about adrenocortical function assessment: How the random cortisol relates to the short Synacthen test ‘Verdict’

Michaelidou Maria , Yadegarfar Ghasem , Robinson Adam , Naseem Asma , Khan Inamullah , Kochhar Rupinder , Scargill Jonathan , Trainer Peter , Heald Adrian

Background: The short synacthen test (SST) is the most commonly performed investigation to assess for suspected adrenocortical dysfunction. We investigated how random cortisol levels may relate to pass/fail on the STT.Methods: We analysed the relation between random cortisol measurements taken between 04.40 and 20.52 in the day and results of SST baseline and 30/60 min cortisol performed over a 12 month period (338 SSTs) at Salford Royal Hospital. Serum ...

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ea0065p190 | Metabolism and Obesity | SFEBES2019

Androgen receptor reduced sensitivity is associated with increased mortality, poor glycemic control and BMI in men with type 2 diabetes – a 14-year follow up study

Heald Adrian , Yadegarfar Ghasem , Livingston Mark , Fachim Helene , Lunt Mark , Narayanan Ram Prakash , Siddals Kirk , Cortes Gabriela , Hackett Geoff , Naseem Asma , Kochhar Rupinder , Inamullah Khan , Donn Rachelle , Gibson Martin , Jones Hugh

Introduction: Hypogonadism is associated with poorer glycaemic outcomes/increased all cause and cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM). Increasing CAG repeat number within exon 1 of the androgen receptor gene is associated with increased androgen receptor resistance/insulin resistance. We here investigated the link between CAG repeat number and outcomes in T2DM men.Methods: We determined in a long-term 14-year follow-up coh...

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Endocrine Abstracts

Recalibration of thinking about adrenocortical function assessment: How the random cortisol relates to the short Synacthen test ‘Verdict’

Androgen receptor reduced sensitivity is associated with increased mortality, poor glycemic control and BMI in men with type 2 diabetes – a 14-year follow up study

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