Searchable abstracts of presentations at key conferences in endocrinology

ea0063p32 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

18-oxocortisol synthesis in aldosterone-producing adrenocortical adenoma and significance of KCNJ5 mutation status

Satoh Fumitoshi Yamazaki Yuto , Morimoto Ryo , Kudo Masataka , Gomez-Sanchez Celso E , Ito Sadayoshi , Sasano Hironobu , Satoh Fumitoshi

Peripheral 18-oxocortisol level could contribute to the detection of aldosterone-producing adenoma in patients with primary aldosteronism. However, peripheral 18-oxocortisol varies among such patients, which is a big drawback concerning its clinical application. We studied 48 cases of aldosterone-producing adenoma, 35 harboring KCNJ5 mutation, to clarify the significance of clinical and pathological parameters regarding peripheral 18-oxocortisol. Peripheral 18-oxocort...

ea0070aep22 | Adrenal and Cardiovascular Endocrinology | ECE2020

The study of cell senescence in cortisol-producing adrenocortical adenoma

Gao Xin , Yamazaki Yuto , Pieroni Jacopo , Tezuka Yuta , Omata Kei , Ono Yoshikiyo , Morimoto Ryo , Nakamura Yasuhiro , Satoh Fumitoshi , Sasano Hironobu

Introduction: Aging is associated with the pathogenesis of many endocrinological disorders, especially for functioning adrenocortical disorders. In addition, mitochondria DNA abnormalities have been reported to be correlated with aging through ROS which eventually resulted in cell senescence. We previously reported that cortisol-producing adenomas (CPA) expressed more abundant cell senescent markers including p16 and p21, compared to other hormone-producing adenomas. However, ...

ea0090rc9.6 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Immunohistochemical analysis of somatostatin receptor 2 and the tumor microenvironment in a large set of pheochromocytomas and paragangliomas

Uchihara Masaki , Tanabe Akiyo , Umamoto Kotaro , Maeshima Akiko Miyagi , Kojima Yuki , Sudo Kazuki , Shimoi Tatsunori , Yamazaki Yuto , Sasano Hironobu , Shimomura Akihiko , Shimizu Chikako , Yonemori Kan , Kajio Hiroshi

Introduction: Pheochromocytoma and paraganglioma (PPGL) are rare endocrine tumors with few effective treatment options for malignant cases. Novel therapeutic indications, such as 177Lu-DOTA-TATE and immune checkpoint inhibitors (ICIs) for patients with PPGL, have been investigated in several clinical trials. Emerging evidence shows that somatostatin receptor 2 (SSTR2) in other cancer types correlates with the tumor microenvironment (TME) activation and could be a predictive bi...