Searchable abstracts of presentations at key conferences in endocrinology

ea0086p124 | Reproductive Endocrinology | SFEBES2022

Divergent G-protein signal control at the very early endosome (VEE) from the dually coupled luteinizing hormone receptor (LHR)

Richardson Rachel , Sposini Silvia , Yildiz Yoldas , Barlow Lucy , Hanyaloglu Aylin

Membrane trafficking of G-protein coupled receptors (GPCRs) is a critical mechanism by which cells mediate complex signaling pathways. Endosomes are increasingly recognized as platforms for GPCR signaling. The VEE was first identified using the LHR, a GPCR that is key in reproduction. We have shown that recycling of the LHR is driven by receptor mediated Gαs cAMP signaling from the VEE and PKA-dependent phosphorylation of the adaptor protein, APPL1, while APPL1 negatively...