Searchable abstracts of presentations at key conferences in endocrinology

ea0051p064 | Diabetes | BSPED2017

Hyperinsulinism Hyperammonemia (HI/HA) syndrome due to GLUD1 mutation: Phenotypic Variations Ranging from Late Presentation to Spontaneous Resolution

Brandt Agnieszka , Giri Dinesh , Yung Zoe , Didi Mohammad , Senniappan Senthil

Introduction: The hyperinsulinism/hyperammonemia (HI/HA) syndrome is the second most common cause of hyperinsulinemic hypoglycaemia (HH), caused by activating mutations in GLUD1 [which encodes the mitochondrial enzyme glutamate dehydrogenase (GDH)].Methods: We describe phenotypic variations in three patients from 3 non-related families with HI/HA syndrome due to GLUD1 mutation.Results: Patient 1, a 10-year-old Cau...

ea0036P62 | (1) | BSPED2014

Lanreotide therapy for congenital hyperinsulinism

Giri Dinesh , Yung Zoe , Didi Mo , Senniappan Senthil

Introduction: Congenital hyperinsulinism (CHI) is the commonest cause of recurrent and persistent hypoglycaemia during the newborn period. The management of CHI in patients who are unresponsive or do not tolerate diazoxide includes the use of octreotide therapy which is given as a SUBCUTANEOUS injection, three to four times daily. We report a case of persistent CHI successfully treated with once monthly Lanreotide (a long acting somatostatin analogue).<p cla...

ea0045p48 | Miscellaneous/other | BSPED2016

Ketotic hypoglycaemia in children with transient congenital hyperinsulinism of infancy

Giri Dinesh , Patil Prashant , Yung Zoe , Didi Mohammed , Senniappan Senthil

Introduction: Congenital hyperinsulinism (CHI) is a rare genetic disorder of unregulated insulin secretion from the pancreatic β-cells leading to severe hypoglycaemia & permanent neurological deficit if not managed appropriately. Kenotic hypoglycaemia (KH), a diagnosis of exclusion, is by far the most common form of hypoglycemia in children between 1–5 years of age characterized by recurrent episodes of hypoglycaemia and ketosis.Aim: To ide...

ea0045p55 | Miscellaneous/other | BSPED2016

Flash glucose monitoring in children with congenital hyperinsulinism; first report on accuracy and patient experience

Alsaffar Hussain , Turner Lucy , Yung Zoe , O'Hara Cheryl , Didi Mohammed , Senniappan Senthil

Introduction: Recently, the factory calibrated FreeStyle Libre (FSL) flash glucose monitoring system has been introduced for use in patients with diabetes mellitus. We assessed the accuracy of FSL compared to the finger prick capillary blood glucose (CBG) over a 2 week period in patients with congenital hyperinsulinism (CHI) and assessed the parents’ experience of using FSL.Methods: About 346 episodes of CBG along with corresponding swipe FSL readin...

ea0085p45 | Pituitary and Growth 1 | BSPED2022

The use of 6-monthly GnRH analogues in the paediatric population

Apperley Louise , Dharmaraj Poonam , Blair Joanne , Ramakrishnan Renuka , Das Urmi , Didi Mohamed , Laing Peter , Yung Zoe , Cassidy Kelly , Blundell Pauline , Jarvis Charlotte , Parkinson Jennifer , Senniappan Senthil

Background: Pubertal progression is inhibited in central precocious puberty with the use of gonadotropin releasing hormone (GnRH) analogues. They are usually given every 10 to 12 weeks via an intramuscular depot, but more recently, a 6-monthly preparation has become available for clinical use.Aim: The aim of this project was to evaluate the efficacy and acceptability of 6-monthly triptorelin, a GnRH analogue, at a tertiary children’s hospital.<p...

ea0039ep3 | Adrenal | BSPED2015

Cortisol responses to the insulin tolerance test and glucagon stimulation tests in children with idiopathic short stature and idiopathic isolated growth hormone deficiency

Alsaffar Hussain , Ahmed Iyad , Blundell Pauline , Das Urmi , Dharmaraj Poonam , Didi Mohammed , Hatchard Lynne , Ramakrishnan Renuka , Senniappan Senthil , Stirrup Kelly , Yung Zoe , Blair Joanne

Introduction: The insulin tolerance test (ITT) and glucagon stimulation test (GST) stimulate the release of both growth hormone (GH) and cortisol. A normal cortisol response is considered to be >500 nmo/l, however there are no robust normative paediatric data. Cortisol results may generate anxiety and further investigations in short children, tested for GH deficiency, with no clinical suggestion of cortisol deficiency.Aim: To describe cortisol respon...