Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp135 | Female Reproduction | ECE2018

Liquid chromatography-tandem mass spectrometry characterization of a broad serum and salivary steroid profile in classical form of polycystic ovary syndrome

Mezzullo Marco , Fanelli Flaminia , Zanotti Laura , Pagotto Uberto , Gambineri Alessandra

Polycystic ovary syndrome (PCOS) is a common endocrine disorder among premenopausal women affecting up to 20% of the population. Even though androgen excess is the main diagnostic criterion for PCOS, the evaluation of hyperandrogenemia relies on methods with low accuracy and mainly able to measure total androgen amounts. Liquid chromatography-tandem mass spectrometry (LC–MS/MS) allows high accuracy steroids measurement and if applied to saliva, it also allows the measurem...

ea0081ep879 | Reproductive and Developmental Endocrinology | ECE2022

Daytime salivary androgen rhythm by LC-MS/MS in women affected by Polycystic Ovary Syndrome (PCOS) fulfilling the three Rotterdam diagnostic criteria

Fanelli Flaminia , Hawley James M , Mezzullo Marco , Fazzini Alessia , Zanotti Laura , Magagnoli Matteo , Pagotto Uberto , Keevil Brian , Gambineri Alessandra

Background: Excess testosterone in PCOS is accompanied by increased levels of other ovarian and adrenal androgens and precursors. Recently, 11-oxygenated adrenal androgens have been postulated as major components of the circulating androgen pool in PCOS. Obesity is strictly connected with androgen excess and with the derangement of hormone circadian rhythmicity. To date, it has not been clarified whether hyperandrogenism in PCOS, either complicated by obesity or not, is accomp...

ea0056p927 | Female Reproduction | ECE2018

Disentangling polycystic ovary syndrome (PCOS) components by liquid-chromatography – tandem mass spectrometry (LC-MS/MS) steroid profiling

Fanelli Flaminia , Mezzullo Marco , Zanotti Laura , Fazzini Alessia , Mastroroberto Marianna , Morselli-Labate Antonio Maria , Pagotto Uberto , Pasquali Renato , Gambineri Alessandra

Introduction: Clinical and laboratory hyperandrogenisms indistinctly contribute to PCOS diagnosis; however, they differ in hormonal and metabolic correlates and require proper therapeutic strategies. Circulating biomarkers of hirsutism were not identified so far, with elevated testosterone being observed only in half of hirsute patients. Reasons for such inconsistencies possibly relies in previously used immunoassays, nowadays recognized as not adequate because of poor reliabi...