Searchable abstracts of presentations at key conferences in endocrinology

ea0014p369 | (1) | ECE2007

CRABP2 expression is up-regulated in parathyroid adenomas in correlation with HRPT2 down-regulation

Zebracka Jadwiga , Waler Janusz , Kowalska Malgorzata , Gala Grzegorz , Gawrychowski Jacek , Jarzab Barbara

Introduction: The molecular events involved in the formation of parathyroid adenomas are not well understood. Two genes, cyclin D1 (CCND1) and MEN-1, have been established as having major roles in parathyroid tumorigenesis. Tumor suppressor gene HRPT2 is frequently mutated in parathyroid carcinoma. The aim of our study was to analyze HRPT2 expression in parathyroid adenomas and in residual normal/atrophic parathyroid tissue and to relate it to other...

ea0014p367 | (1) | ECE2007

Expression of folate receptor is down-regulated in somatotropinomas

Zebracka Jadwiga , Rudnik Adam , Lazar Kornelia Hasse , Larysz Dawid , Jarzab Michal , Lubieniecka Beata , Gala Grzegorz , Jarzab Barbara

Introduction: Pathogenesis of pituitary adenomas is largely unknown thus, identification of genes specific for various types of pituitary tumors should enable better understanding of their biology.The aim of our study was to analyze differences in gene expression between functional (FA) and non-functional (NFA) pituitary adenomas. For this goal, we considered folate receptor (FOLR1) shown by previous study (Evans et al. 2003) to be overexpr...

ea0014p368 | (1) | ECE2007

Initiating mutations of BRAF gene in papillary thyroid carcinoma and their relation to gene expression profile

Rusinek Dagmara , Wiench Malgorzata , Oczko-Wojciechowska Malgorzata , Zebracka Jadwiga , Kowalska Malgorzata , Handkiewicz-Junak Daria , Szpak-Ulczok Sylwia , Chmielik Ewa , Czarniecka Agnieszka , Jarzab Michal , Gala Grzegorz , Gubala Elzbieta , Jarzab Barbara

Introduction: Discovery of V600E (BRAFT1799A) mutation in papillary thyroid carcinoma (PTC) widened our knowledge about mechanisms of its molecular initiation. It has been revealed that activating mutations of the BRAF kinase are much more frequent in PTC than RET rearrangements.Aim of the study: Estimation of V600E BRAF mutation frequency in PTC and analysis of differences in gene expression profile between papillary thyroid car...