Searchable abstracts of presentations at key conferences in endocrinology

ea0029oc17.4 | Diabetes Basic | ICEECE2012

Syntaxin-3 regulates recruitment and exocytosis of newcomer insulin granules and granule-granule fusion during biphasic glucose-stimulated insulin secretion in pancreatic β-cells

Zhu D. , Koo E. , Kwan E. , Kang Y. , Park S. , Xie H. , Sugita S. , Gaisano H.

Introduction: The molecular basis of exocytosis of secretory insulin-containing granules (SGs) during biphasic glucose-stimulated insulin secretion (GSIS) of pancreatic β-cells remains unclear. Syntaxins (Syns) Syn-1A and Syn-4 are t-SNARE proteins situated on the plasma membrane that have been well studied to mediate insulin exocytosis. However, Syn-3, peculiarly more abundant in insulin SGs, has unclear function in GSIS.Methods/Designs: Confocal m...

ea0029oc3.3 | Diabetes Clinical | ICEECE2012

Diabetic ketoacidosis at diagnosis influences complete remission after treatment of hematopoietic stem cell transplantation in adolescents with type 1 diabetes

Gu W. , Hu J. , Zhu D. , Tang W. , Li L. , Cui W. , Hong J. , Zhang Y. , Wang W. , Ning G.

Objective: To determine if autologous nonmyeloablative hematopoietic stem cell transplantation (AHSCT) was worthwhile to do in type 1 diabetes adolescents with diabetic ketoacidosis at diagnosis.Research Design and Methods: We enrolled 28 type 1 diabetes patients aged 14–30 years in a prospective AHSCT phase II clinical trial. Hematopoietic stem cells were harvested from the peripheral blood following a pretreatment consisting of a combination of cy...