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ea0029s1.1 | Molecular mechanisms of differentiated thyroid cancer | ICEECE2012

Molecular consequences of deregulated RNA genes in papillary thyroid carcinoma

de la Chapelle A.

Early miR expression analyses in papillary thyroid carcinoma (PTC) disclosed profound differences in the expression of several, microRNAs in thyroid tumor compared with unaffected thyroid tissue. For instance, miR146 and miR221 were 19- and 11-fold upregulated in PTC. These and other miRs target the thyroid hormone receptor THRB gene. Transfection of cell lines with miR146a and other miRs in vitro resulted in down-regulation of THRB transcript and protein. Promoter luci...