Endocrine Abstracts

Background: This study was carried out to assess the vasodilatory effect of oestrogen in the human pulmonary circulation. The influence of gender upon the response to oestrogen was also assessed.Method: Isolated human pulmonary arteries were studied by wire myography. Vessels were obtained from male (n=6, age 70±9 years) and female (n=6, age 59±9 years) patients. The study was approved by the local ethics committee. Vessels were p...

Phyto-oestrogens are plant-derived compounds that have oestrogenic and/or anti-oestrogenic activity. They are constituents of many human foodstuffs but exposure is on the increase due to increasing availability of ‘herbal’ type medicines. The current study was initiated following the identification of large concentrations of lignan related phyto-oestrogen metabolites in the urine from a girl under investigation for precocious puberty.A GC-MS pr...

Introduction: AMH is produced by the sertoli cells in the testes and is responsible for the regression of the Mullerian structures in the male fetus. It is also produced by the granulosa cells of the ovaries in females to a lesser degree. Serum AMH measurements may be important for detecting testicular tissue and monitoring ovarian activity. The objective of this study was to establish a cross-sectional reference range for AMH in UK children.Method: Seru...

The aim of this publication is to address an attention to possible misdiagnosis in patients with 17-alpha-hydroxylase deficiency.A 24 year old woman was admitted to our Centre with diagnosis of aldosteroma (aldosterone – 486 pmol/l (22–478), hypertension, hypokaliemia, adrenal mass (d–2.2 sm) defined by ultra sound). At the age of 15 years the patient was diagnosed with testicular feminisation as the cause of absent puberty (karyotype &#15...

Objective: There is currently extensive debate regarding elevated TSH (Thyroid Stimulating Hormone) concentrations and associated cardiovascular risk. This study investigated whether correlations exists between TSH concentrations within the accepted range of normality and increasing cardiovascular risk.Design: We performed a cross-sectional study of 728 asymptomatic women aged 45–60 years attending for thyroid screening over a twelve month period. P...

There is no ideal treatment for the simple goiter. The treatment options in NMG is: surgery, I131, L-thyroxine or continous monitoring without therapy.From 2000–2003 we evaluated 150 patients (120 women and 30 men) having their agings between 20 and 80 years with L-T4 treatment for nontoxic multinodular goiter. Duration of therapy was 3 years. The pacients was evaluated by clinical examination, level of TSH, free-T4,...

A 30year old Afrocarribean man with sarcoidosis presented with unexplained weight gain from 98kg to 112kg over 6 months. He had previously documented bilateral hilar lymphadenopathy, erythema nodosum, arthralgia, a positive gallium scan and a raised serum angiotensin converting enzyme(ACE).He also described hypersomnolence, impaired concentration, decreased libido and intermittent headaches with no other neuro-psychiatric symptoms. He was not on any regu...

This study examined the effects of maternal diet during late pregnancy and body shape at birth, on postnatal plasma concentrations of IGF1 and leptin.From day 85 of gestation pregnant sows were offered the standard diet (S: n=4) or the S diet plus 30% extra energy derived from either carbohydrate (C: n=5) or palm oil (PO: n=5). Piglets were selected from the normal distribution curve of Ponderal Index (PI: kg/m3), long and thin (Thin<10 <su...

This study examined the effects of maternal diet during late pregnancy and body shape at birth, on postnatal plasma concentrations of IGF1 and leptin.From day 85 of gestation pregnant sows were offered the standard diet (S: n=4) or the S diet plus 30% extra energy derived from either carbohydrate (C: n=5) or palm oil (PO: n=5). Piglets were selected from the normal distribution curve of Ponderal Index (PI: kg/m3), long and thin (Thin<10 <su...

A 30year old Afrocarribean man with sarcoidosis presented with unexplained weight gain from 98kg to 112kg over 6 months. He had previously documented bilateral hilar lymphadenopathy, erythema nodosum, arthralgia, a positive gallium scan and a raised serum angiotensin converting enzyme(ACE).He also described hypersomnolence, impaired concentration, decreased libido and intermittent headaches with no other neuro-psychiatric symptoms. He was not on any regu...