Endocrine Abstracts

Patients with Cushing's disease are well known to develop easy bruising due to cortisol excess but are also predisposed to thrombembolism.We present four patients who developed thromboembolism during active Cushing's disease.Case 1- Four year history of hypertension, osteoporosis and central obesity. A DVT developed prior to referral. Initial urinary free cortisol(UFC)was 524nmol/24hrs. Inferior petrosal sinus sampling indicated ...

We report the case of a 57-year-old woman who presented with headache of sudden onset and with blurring of vision in the right eye. This had been preceded by a week's history of fever, rigors and coryzal symptoms which had been treated as malaria and had subsequently settled. Examination demonstrated proptosis and complete ophthalmoplegia of the right eye with 6/60 acuity. Baseline investigations included normal urea and electrolytes, clotting screen and full blood count, with...

Much controversy exists surrounding, the screening, diagnosis, treatment and even existence of gestational diabetes mellitus (GDM). This study aims to compare sensitivity and cost of two screening strategy of GDM.2416 pregnant women referred to five university hospital clinics were followed up until delivery. The universal screening performed. Obstetric and family histories were taken followed by a complete physical examination. Retrospectively were conc...

A case - control study was conducted on 2416 pregnant women referred to five university hospital clinics. The universal screening was performed with a 50g 1-hour glucose challenge test and those with plasma glucose level >= 130mg/dl, were diagnosed as having GDM if they had an impaired 100g 3-hour glucose tolerance test based on Carpenter and Coustan criteria. Overall 114 GDM patients were identified who were matched to 220 normoglycemic pregnancies in view of age, BMI, pa...

Background and aims: Cardiovascular (CVS) disease accounts for the majority of morbidity and mortality in diabetes. We audited lipid management in a hospital diabetes clinic.Patients: CVS disease risk factors were assessed in 241 consecutive patients with diabetes (type1 15%, type2 85%, male 53%, female 47%, mean age 59±13 years, mean duration of diabetes 10±9 years). 86(36%) had symptomatic atherosclerotic vascular disease (secondary prev...

Background: Aromatase inhibitors block the aromatization of androgens to oestrogen. They are used off-label to delay bone maturation where bone age (BA) is advanced secondary to androgen excess. Side effects include hair loss, headache, decreased appetite, bone pain, drowsiness, and osteoporosis. There is limited data on Anastrozole’s safety in paediatrics. We report our experience (Anastrozole 1 mg OD) in 4 pre-pubertal boys with advanced BA.<p class...

Introduction: Hyperparathyroidism (HPT) during pregnancy is rare but requires a specific approach for its diagnosis HPT is associated with a high incidence of associated maternal, fetal and neonatal complications, including miscarriage (3,5x-fold higher than expected), IUGR, prematurity and pre-eclampsia(1,2,3). The severity of complications is proportional to degree of maternal calcium level.Case report: We report the c...

Background: Overt hypothyroidisms warrants L-T4 treatment, but treatment in subclinical hypothyroidism (ScH), especially in mild form of ScH (TSH between 4,2-10mU/l and normal free thyroxine) is unknown.Objectives: To compare the presence of risk factors for atherosclerosis in patients with mild form of ScH to euthyroid subjects.Methods: Prospectively 67 consecutive patients with newly diagnosed ScH, and 30 healthy subjects were re...

Background and aims: HbA1c as a gold-standard measure for glycaemic control has been criticized for several years: lacking the ability to capture hypoglycaemia, time spent in different glucose ranges or to reflect glycaemic variability (GV) are frequently reported shortcomings. Continuous glucose monitoring (CGM) can overcome this, and several new CGM-derived parameters have been proposed to provide additional insights, with the concept of time in range (TIR) and other paramet...

Introduction: Hashimoto’s thyroiditis (HT) is one of the frequent endocrine disorder. Clinical picture in Hashimoto’s thyroiditis is predominantly due to associated hypothyroidism and/or goiter related neck complaints. Rarely, HT can be associated with recurrent encephalopathy characterized by seizures, amnesia and comatose episodes. The etiology of this Hashimoto’s encephalopathy (HE) is enigmatically idiopathic and hypothesized to be autoimmune in origin. The ...