Endocrine Abstracts

B Allolio, Department for Endocrinology and Diabetes, University of Wuerzburg, Wuerzburg, Germany AbstractBruno Allolio received his Bachelor of Physics Degree in 1974 and graduated in Medicine from the University of Cologne in 1975. He obtained his MD in 1977 and trained in General Medicine and Endocrinology at the University Hospital Cologne. He received basic science training under the auspices of John Landon at Ba...

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‘HM’ 39-year-old.TAH & BSO 1 year ago for mennorhagia and endometriosis, at another hospital. No serious pathology.Patient c/o hot flushes, lethargy, mood swings and low libido.Treated by GP for frequent migraines but no visual problems.Family h/o Cardio-Vascular disease;Grandfather MI RIPFather MI Alive & well<p class=...

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B Spiegelman, Dana-Farber Cancer Institute, Boston, United States. AbstractA professor of Cell Biology at Dana-Farber and Harvard Medical School, Spiegelman earned his undergraduate degree with highest honours from the College of William and Mary in Williamsburg, Va., and his PhD in biochemistry from Princeton University. He completed his postdoctoral work at the Massachusetts Institute of Technology.<p class="abst...

The cardiovascular system is one of the major targets of thyroid hormone action, sensitive enough to detect the effects of thyroid hormone excess or deficiency at tissue level. Triiodothyronine (T3) acts on the heart and vascular system by classic genomic as well as non-genomic mechanisms and influences heart rate, systolic and diastolic function and systemic vascular resistance thereby affecting cardiac performance. In human short-term overt hyperthyroidism, the increase in l...

58 year old man – Mr CBType 2 diabetes for 16 yearsWell controlled hypertensionMicroalbuminuria with ACR 19Persistent haematuria with stone diseaseNo retinopathy or neuropathyNo macrovascular diseaseOtherwise fit and well</p...

The brain is dependent on a continuous supply of glucose as its source of energy, the rate-limiting step being the rate of transport across the blood-brain barrier. Glucose deprivation of the brain causes neuroglycopenia and rapid malfunction. This is demonstrated by the development of abnormal neurophysiological function with slowing of neural transmission and electroencephalographic changes, and by the progressive impairment of cognitive function, affecting several domains. ...

DHEA and its sulfate ester DHEAS are the major steroids secreted by the adrenal zona reticularis. DHEA exerts its action either indirectly in peripheral target tissues following its conversion to potent sex steroids or directly as a neurosteroid. Moreover, there is growing evidence of high affinity binding sites on endothelial cells and lymphocytes suggestive of the presence of a specific DHEA receptor. Studies in patients with adrenal insufficiency (AI) have elucidated the ro...