Endocrine Abstracts

We have previously shown that the PGC-1 transcriptional coactivators are major regulators of several crucial aspects of energy metabolism. PGC-1alpha controls many aspects of oxidative metabolism, including mitochondrial biogenesis and respiration through the coactivation of many nuclear receptors, and factors outside the nuclear receptor family. ERRalpha NRF-1 and NRF-2 are key targets of the PGC-1s in mitochodrial biogenesis. We have recently addressed the question of the ro...

B Spiegelman, Dana-Farber Cancer Institute, Boston, United States. AbstractA professor of Cell Biology at Dana-Farber and Harvard Medical School, Spiegelman earned his undergraduate degree with highest honours from the College of William and Mary in Williamsburg, Va., and his PhD in biochemistry from Princeton University. He completed his postdoctoral work at the Massachusetts Institute of Technology.<p class="abst...