Searchable abstracts of presentations at key conferences in endocrinology
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Summary
Abstracts
Contents
Plenary Lecturers’ Biographical Notes
Society for Endocrinology Dale Medal Lecture
The ever expanding role of somatostatin receptors in endocrine disease
ea0013s1
Society for Endocrinology Dale Medal Lecture
ea0013s1biog
Society for Endocrinology Transatlantic Medal Lecture
PGC-1 coactivators and the control of energy homeostasis
ea0013s2
Society for Endocrinology Transatlantic Medal Lecture
ea0013s2biog
Society for Endocrinology Asia and Oceania Medal Lecture
From Ad4BP/SF-1 to cell and tissue differentiation
ea0013s3
Society for Endocrinology Asia and Oceania Medal Lecture
ea0013s3biog
Society for Endocrinology European Medal Lecture
GH/IGF-I and the cardiovascular system
ea0013s4
Society for Endocrinology European Medal Lecture
ea0013s4biog
The British Thyroid Association Pitt Rivers Lecture
Genes that mediate thyroid hormone functions in development
ea0013s5
The British Thyroid Association Pitt Rivers Lecture
ea0013s5biog
Clinical Endocrinology Trust Visiting Professor Lecture
Genes and environment in the pathogenesis of polycystic ovary syndrome (PCOS)
ea0013s6
Clinical Endocrinology Trust Visiting Professor Lecture
ea0013s6biog
Society for Endocrinology Medal Lecture
Cortisol and cardiovascular disease: from cradle to grave
ea0013s7
Society for Endocrinology Medal Lecture
ea0013s7biog
Clinical Endocrinology Trust Lecture
Failing to stop, failing to signal, no insurance, and other trafficking defects in the adrenal
ea0013s8
Clinical Endocrinology Trust Lecture
ea0013s8biog
Symposia
Transdifferentiation in the endocrine system
Fibroblasts and tissue remodelling: Defining a role for fibroblasts in the persistence of chronic inflammation
ea0013s9
Transdifferentiation in the osteoblast
ea0013s10
Plasticity of the adipose organ
ea0013s11
Pancreatic trans-differentiation and the treatment of liver damage
ea0013s12
Thyroid and autoimmunity
Pathogenic and regulatory T cells in a humanised model of hypothyroidism
ea0013s13
Novel animal models of Graves hyperthyroidism
ea0013s14
The TSH receptor: from natural variants to structure and function
ea0013s15
TSH receptor antibodies should we measure them and if so how?
ea0013s16
Endocrinology of senescence
The role of androgens in the ageing male
ea0013s17
Estrogen receptors in development and ageing
ea0013s18
Functional decline in mobility muscles and somatopause
ea0013s19
Stress hormones, innate immunity and ageing
ea0013s20
Endocrine stem cells
Precursors to pancreatic beta cells
ea0013s21
Replacing beta cells: proof-of-principle and the stem cell option
ea0013s22
Nuclear transfer and stem cell-based therapies: tailored treatment
ea0013s23
Conditional ablation and regeneration of pancreatic beta cells
ea0013s24
Novel endocrine consequences of stress
New roles for the CRF-R2
ea0013s25
Exercise alters endocrine and behavioural consequences of stress
ea0013s26
Corticotropin Releasing Hormone (CRH) system and inflammation
ea0013s27
Urocortins and peripheral energy metabolism
ea0013s28
Vitamin D – new perspectives
The Vitamin D receptor as a dual-functional mediator of endocrine and detoxification pathways
ea0013s29
The epithelial calcium channels: uniquely regulated gatekeepers
ea0013s30
Vitamin D and cancer prevention
ea0013s31
Vitamin D and autoimmune disease
ea0013s32
Animal disease, paradigm for human conditions
Hyperadrenocorticism current treatment options
ea0013s33
Stress and sex on the farm lessons for humans
ea0013s34
Canine diabetes mellitus
ea0013s35
Feline hyperthyroidism: parallels with human hyperthyroidism
ea0013s36
Aspects of cardiovascular risk management in diabetes
The value of PPAR agonists in relation to endothelial function
ea0013s37
Developments in the dyslipidaemia of diabetes
ea0013s38
Cardiovascular risk and risk management in type 1 diabetes
ea0013s39
Aldosterone induced vascular inflammatory disease: Mechanisms and implications for clinical practice
ea0013s40
New biology of bone: therapeutic implications
LRP5
ea0013s41
Osteoclast differentiation and function
ea0013s42
Rank modulation in treatment
ea0013s43
Cathespins and bone and other new targets
ea0013s44
Clinical Management Workshops
Management of endocrine disorders in pregnancy: the mother and the child
Hyperglycaemia in pregnancy
ea0013s45
CAH pregnancy and antenatal glucocorticoid treatment
ea0013s46
Thyroid disease in pregnancy
ea0013s47
Maternal vitamin D status in pregnancy and risk to the child
ea0013s48
The use of insulin sensitisers in the adolescent
ea0013s49
The role of weight reduction strategies in the management of PCOS
ea0013s50
Practical aspects of managing subfertility in polycystic ovary syndrome
ea0013s51
Management of the cosmetic aspects of PCOS
ea0013s52
New aspects of phaeochromocytoma
Familial phaeochromocytoma syndromes
ea0013s53
New aspects of phaeochromocytoma: Managing young people with phaeochromocytoma
ea0013s54
Biochemical testing which test in which patient
ea0013s55
Clinical case discussion
ea0013s56
Differentiated thyroid cancer
Clinical management of thyroid cancer: new guidelines
ea0013s57
Surgical management of differentiated thyroid cancer (DTC)
ea0013s58
An update in the management practices of thyroid cancer and the use of rhTSH
ea0013s59
Nurse Session
Thyroid cancer – more than a lump in the neck
Helping the patient through different types of thyroid cancer
ea0013s60
Controlling calcium following thyroidectomy
ea0013s61
Patient groups and the nurses involvement
ea0013s62
The thyroid cancer patient journey and the role of the clinical nurse specialist
ea0013s63
Dealing with MEN
Dealing with MEN: an overview
ea0013s64
Genetic counsellor contribution to the MEN patient
ea0013s65
Dealing with MEN: A paediatric perspective
ea0013s66
Adult case
ea0013s67
Young Endocrinologists Session
A successful research career
MD VS PhD
ea0013s68
Managing your PhD
ea0013s69
Fraud and plagiarism
ea0013s70
Making money out of research
ea0013s71
Molecular Endocrinology Workshop
Nuclear hormone receptor-chromatin interactions: new approaches and insight into dynamics
Chip-chip approaches to understanding ER function
ea0013s72
Dynamics of nuclear receptor interactions on chromatin
ea0013s73
Clinical and Basic Review Lectures
Applications of proteomics in translational research
Proteomics in research and clinic
ea0013s74
Pharmacological aspects of appetite control
The obesity pipeline: current strategies in the development of anti-obesity drugs
ea0013s75
Education Technology Session
Science
Role of micro RNAs in development and disease
ea0013s76
Clinical Debate
This house believes that all patients with sub-clinical thyrotoxicosis should be treated
This house believes that all patients with subclinical thyrotoxicosis should be treated: For the motion
ea0013d1
This house believes that all patients with subclinical thyrotoxicosis should be treated: Against the motion
ea0013d2
Oral Communications
Steroid synthesis and action
Monogenic polycystic ovary syndrome (PCOS) due to novel mutations in the H6PD gene - apparent cortisone reductase deficiency (ACRD)
ea0013oc1
Mouse melanocortin-2 receptor accessory protein: expression pattern and protein characterisation
ea0013oc2
Transcriptional regulation of 11beta-hydroxysteroid dehydrogenase type 1 under the synergistic control of glucocorticoids and cytokines
ea0013oc3
Modulation of membrane initiated glucocorticoid signalling by caveolin-1
ea0013oc4
Society for Endocrinology/Clinical Endocrinology Trust Young Investigator Basic Prize winner
Hexose-6-phosphate dehydrogenase: A novel regulator of glucocorticoid hormone action
ea0013oc5
A novel tethering mechanism explains cell type specific glucocorticoid repression of macrophage migration inhibitory factor (MIF)
ea0013oc6
Differential effects of P450 oxidoreductase mutants on CYP17 activity provides evidence for an alternative pathway in human androgen biosynthesis
ea0013oc7
Clinical and translational endocrinology
Effect of once-yearly infusion of Zoledronic acid 5 mg in postmenopausal women with osteoporosis
ea0013oc8
A novel homozygous inactivating mutation, Pro339Thr, of the calcium-sensing receptor is associated with isolated primary hyperparathyroidism
ea0013oc9
Expression of the orphan nuclear receptors oestrogen receptor related (ERR) alpha and beta in the human endometrium: implications for oestrogen receptor signalling
ea0013oc10
Reduced 5α-reductase activity in peripheral blood mononuclear cells in polycystic ovarian syndrome a compensatory mechanism for androgen excess?
ea0013oc11
Local and systemic consequences of glucocorticoid metabolism in synovium
ea0013oc12
Relative protection of cortical bone in women with complete androgen insensitivity syndrome compared to women with gonadal dysgenesis
ea0013oc13
A two-centre experience of long-term pegvisomant therapy in 58 patients
ea0013oc14
Biological variability of insulin resistance in polycystic ovarian syndrome after treatment with Metformin, Orlistat and Pioglitazone
ea0013oc15
Young Endocrinologist prize session
Heterozygous missense mutations in steroidogenic factor 1 (SF1/Ad4BP, NR5A1) cause 46,XY disorders of sex development with normal adrenal function
ea0013oc16
Novartis Clinical Endocrinology Award
Kisspeptin-54 potently stimulates luteinising hormone release during the preovulatory phase of the menstrual cycle in healthy human females.
ea0013oc17
Sedlin mutations disrupt interactions with pituitary homeobox 1 (Pitx1) and steroidogenic factor 1 (SF1): potential cause of delayed puberty in boys with Spondyloepiphyseal dysplasia tarda (SEDT)
ea0013oc18
Novartis Basic Endocrinology Award
Steroidogenic gene transcription in the human hippocampus and cerebellum: a comprehensive survey
ea0013oc19
Insulin fails to limit proteolysis in critically-ill medical patients to rates observed after cardiothoracic surgery
ea0013oc20
Muscle cell differentiation is regulated by glucocorticoids, a process which is potentiated through the induction of 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
ea0013oc21
Mice deleted for a Multiple Endocrine Neoplasia Type 1 (MEN1) allele develop pancreatic, pituitary and parathyroid tumours in association with hypercalcaemia
ea0013oc22
The corticotropin-releasing factor type 2 receptor selective ligand Urocortin 3 suppresses angiogenesis
in vitro
and
in vivo
ea0013oc23
Neuroendocrinology, reproduction and cardiovascular
Acute aldosterone responses to ACTH predict both cortisol responses and blood pressure
ea0013oc24
Manipulation of proprotein convertase 1 expression in AtT20 cells changes proopiomelanocortin processing and trafficking: Implications for ACTH regulatory pathways
ea0013oc25
Molecular mechanism of action of annexin A1 in controlling hormone release from neuroendocrine cells
ea0013oc26
Manganese-enhanced MRI demonstrates that oxyntomodulin and GLP-1 affect neuronal activity in distinct regions of the brain
ea0013oc27
The effect of glucocorticoid withdrawal after long-term treatment on POMC and its transcription factors
ea0013oc28
Effects of insulin-like growth factor 1 (IGF-1) on early folliculogenesis in polycystic ovaries from ovulatory and anovulatory women
ea0013oc29
Consequences of variation in the CYP11B2 and CYP11B1 genes on hypothalamic-pituitary-adrenal axis activity
ea0013oc30
2005 Pfizer Award
Evidence for associations between fibroblast growth factor 1 gene and human hypertension
ea0013oc31
Society for Endocrinology/Clinical Endocrinology Trust Young Investigator Clinical Prize winner
Extreme insulin resistance syndromes beyond glucose homeostasis
ea0013oc32
Tag SNP screening of the PDCD1 gene for association with Graves disease
ea0013oc33
British Thyroid Association Award
Monocarboxylate transporter 8 (MCT8) represses proliferation of fetal embryonal NT2 and placental JEG-3 cells
in vitro
ea0013oc34
A prothrombotic clot structure in hyperthyroidism: A mechanism for increased thrombosis in hyperthyroid individuals?
ea0013oc35
Comparsion of the NFκB and JNK mediated inflammatory mechanisms for production of adipocytokines in paired human epicardial and gluteo-femoral adipose tissue from CABG patients
ea0013oc36
Testosterone replacement attenuates fatty streak formation and improves the HDLC profile in the Tfm mouse: an effect which is independent of the classical androgen receptor
ea0013oc37
The novel thyroid hormone derivative 3-iodothyronamine increases food intake via the hypothalamic arcuate nucleus
ea0013oc38
Poster Presentations
Bone
Characterisation of 25 calcium-sensing receptor mutations in disorders of calcium homeostasis
ea0013p1
Mechanisms of DNA binding by the transcription factor GATA3 revealed by mutations causing the hypoparathyroidism-deafness-renal dysplasia (HDR) syndrome
ea0013p2
Differences in parathyroid hormone secretory rhythm and sensitivity in aging women with osteoporosis and declining insulin like growth factor-1 concentration, compared to young healthy premenopausal women
ea0013p3
Mapping of a renal calcification locus to a 5-megabase region on mouse chromosome 17B1/B2
ea0013p4
68
Ga-DOTANOC based PET-CT co-registration: A novel approach for a rapid and precise tumor localization in oncogenic osteomalacia
ea0013p5
Endocrine effects of depot medroxyprogesterone acetate in young women
ea0013p6
Can cinacalcet predispose patients to developing postoperative hypocalcaemia following parathyroidectomy for secondary hyperparathyroidism?
ea0013p7
Case of parathyroid carcinoma with severe hungry bone syndrome
ea0013p8
Diurnal variation in total and bioavailable oestradiol in aging men with osteoporosis
ea0013p9
Calcium homeostasis and parathyroid function in Gata3 knockout mice: relevance to the human hypoparathyroidism, deafness and renal dysplasia syndrome
ea0013p10
Alendronate accelerates increases in bone mineral density with growth hormone replacement but may attenuate the anabolic effect of growth gormone replacement on bone in adult growth hormone deficiency
ea0013p11
Localisation of a renal calcification locus to a 5 Mbp-region on mouse chromosome 11D-E2
ea0013p12
Expression and functional consequences of 11b-HSD1 and H6PDH activity in mouse bone cells
ea0013p13
Fractures following orthotopic liver transplantation
ea0013p14
Hypercalcaemia from vitamin D supplements and parathyroid autonomy: the hazards of DIY therapeutics
ea0013p15
Wnt/β-catenin signalling is abrogated in mice with a targeted mutation in the thyroid hormone receptor (TR) β gene and a thyrotoxic skeletal phenotype
ea0013p16
Clinical practice/governance and case reports
Isolated ACTH deficiency in a case of Thyrotoxicosis. Spontaneous cure of ACTH deficiency occurred following radioactive treatment of thyrotoxicosis and its resolution.
ea0013p17
Isolated ACTH deficiency presenting twenty two years after radiotherapy for nasopharyngeal carcinoma
ea0013p18
Spontaneous recurrent hypoglycaemia due to metastatic gatrointestinal stromal tumour (GIST)
ea0013p19
Hypokalemia and paralysis- 2 case reports
ea0013p20
Hypercalcemia of benignancy
ea0013p21
The steroid mask
ea0013p22
An rare cause of reversible left bundle branch block
ea0013p23
A case of reversible right-sided heart failure due to Graves disease
ea0013p24
Unilateral blindness following transphenoidal hypophysectomy for large non-functioning pituitary adenoma
ea0013p25
Chorea - A rare manifestation of hyperthyroidism
ea0013p26
Familial hypoparathyroidism- case notes review and relevance to clinical practice
ea0013p27
Pseudohypoparathyroidism type 1B complicated by parathyroid bone disease and clubbing
ea0013p28
Hyperkalemia in a district general hospital
ea0013p29
Two cases of idiopathic hypopituitarism Was more intensive investigation required?
ea0013p30
The assessment of growth hormone deficiency following pituitary surgery a need for greater awareness
ea0013p31
Spontaneous pregnancy in a woman with premature ovarian failure-a case report
ea0013p32
An overnight water deprivation test?
ea0013p33
Co-existence of elevated PTH and PTHrP
ea0013p34
Pregnancy, hyperaldosteronism and an adrenal mass were we Conned?
ea0013p35
Cabergoline treatment resulting in rapid changes to a prolactinoma
ea0013p36
Shrinking adrenal mass: Case report of an adrenal pseudocyst
ea0013p37
A case of recurrent hypoglycemia in a patient with type 1 diabetes: when the obvious is not so obvious!
ea0013p38
Cinecalcit in the treatment of resistant hypercalcaemia of parathyroid cancer
ea0013p39
Case report: Severe hypoglycaemia associated with uterine fibroid
ea0013p40
Can parathyroid hormone (PTH) levels be useful in predicting postoperative hypocalcaemia in patients undergoing parathyroidectomy?
ea0013p41
Turner syndrome and apparent absent uterus: a case report and review of literature
ea0013p42
Severe hyponatraemia how low can you go?
ea0013p43
Should primary care have direct access to thyroid ultrasound?
ea0013p44
Di-George syndrome presenting as hypocalcaemia in adulthood
ea0013p45
Drug-induced symptomatic hypomagnesaemia and hypocalcaemia
ea0013p46
Audit of testosterone replacement therapy at South Tyneside
ea0013p47
Restoration of gonadal function and development in hypogonadotrophic hypogonadism
ea0013p48
Severe cushings syndrome associated with metastatic prostate adenocarcinoma
ea0013p49
Ectopic peptide production by phaeochromocytomas
ea0013p50
Medical treatment in adrenal insufficiency: Does the patients quality of life differ depending on which glucocorticoid is given?
ea0013p51
Primary hyperparathyroidism an unusual cause of hyperemesis gravidarum
ea0013p52
Resistant hypercalcaemia: is it always what we think?
ea0013p53
Safety of growth hormone replacement in patients with non-irradiated pituitary and peri-pituitary tumours
ea0013p54
A case of giant macroprolactinoma- rapid response to dopamine agonist therapy
ea0013p55
Iron deficiency, hypopituitarism and occrams razor
ea0013p56
Malignancy associated hypercalcemia with elevated levels of parathormone
ea0013p57
Extreme pituitary hyperplasia of normal pregnancy presenting as a macroprolactinoma
ea0013p58
How do we manage adrenal incidentalomas an audit of referrals to a teaching hospital endocrine unit
ea0013p59
Short Synacthen Test (Standard and Low dose): Do we need multiple cortisol samples?
ea0013p60
A 57 year old lady bilateral adrenal mass and adrenal insufficiency
ea0013p61
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia presenting as cyclical Cushings Syndrome
ea0013p62
Mixed TSH and GH secreting pituitary macroadenoma presenting with profound weight loss: A case report
ea0013p63
Synacthen Tests Do we overinvestigate?
ea0013p64
Application of specific thyroid function test reference range in pregnancy
ea0013p65
Has the management of treated hypothyroid mothers improved?
ea0013p66
Fluconazole is as effective as Ketoconazole in controlling hypercortosolism
ea0013p67
Recurrent cystic pituitary lesion - A case report
ea0013p68
Successful management of a patient with a carcinoid tumour through 2 major operations using Octreotide A case report
ea0013p69
Serum prolactin normalisation does not always predict tumour shrinkage in prolactinomas: A case report.
ea0013p70
Psychosis in a patient with acromegaly: Implications for clinical practice
ea0013p71
A cost benefit analysis of gastric electrical stimulation (GES) in patients with severe diabetic gastoparesis
ea0013p72
Recurrent hypoglycaemia caused by metastatic insulinoma in a patient with Type 2 diabetes
ea0013p73
Unusual cause of adult onset hypoglycaemia post gastric bypass surgery
ea0013p74
Hypercalcaemia associated with HTLV-1 seropositivity, but with no evidence of lymphoma
ea0013p75
Acute falciparum malaria and parathyroid function
ea0013p76
The role of an endocrine specialist nurse in a nurse led testosterone implant clinic
ea0013p77
Apparent hypopituitarism secondary to Cushings syndrome due to adrenal carcinoma
ea0013p78
Postmenopausal hyperandrogenism of ovarian origin: diagnostic and therapeutic difficulties
ea0013p79
Hyperchloraemic metabolic acidosis with hypokalaemia and osteomalacia
ea0013p80
Use of anti thyroid hormone receptor antibody (TRAB) in Graves Disease
ea0013p81
Prolonged hypocalcaemia following intravenous pamidronate in hypoparathyroidism
ea0013p82
Pituitary tumour Contraindication to thrombolysis; Caution with antiplatelet agents
ea0013p83
Pseudo-Bartters in diuretic and laxative abuse
ea0013p84
Long term follow up following focused parathyroidectomy for primary hyperparathyroidism
ea0013p85
An audit on the effectiveness of a change in RAI regime for patients with hyperthyroidism
ea0013p86
Radioactive Iodine (I-131) and its effectiveness in treating benign thyroid disease
ea0013p87
Hypoglycaemia secondary to leukamoid reaction
ea0013p88
Severe hyperkalaemia and hyponatramia with grossly elevated aldosterone: pseudohypoaldosteronism
ea0013p89
Primary hyperparathyroidism in pregnancy-an increasingly common condition?
ea0013p90
Unusual presentation of thyroid storm
ea0013p91
Gynecomastia caused by a urinary bladder carcinoma secreting human chorionic gonadotropin
ea0013p92
NICE Guidelines for Adult Growth Hormone replacement: an audit of impact on practice in Scotland
ea0013p93
Comparison of 30 minute Short Synacthen test and 60 minute Short Synacthen test for assessment of the hypothalamo-pituitaryadrenal axis
ea0013p94
Lanreotide (Somatuline Autogel) causes marked tumour shrinkage in a case of gigantism
ea0013p95
Cranial diabetes insipidus: An interesting case
ea0013p96
Endocrine hypofunction as a consequence of metastatic cancer
ea0013p97
Unusual cause of adrenal insufficiency
ea0013p98
Use of thyroid function tests in medical inpatients in a District General Hospital
ea0013p99
Endocrine Diagnostic Tests: A smoother, more legal diagnostic journey for the patient travelling through the Endocrine Test Care
ea0013p100
Carneys Triad
ea0013p101
Gastric adenocarcinoma and ectopic ACTH syndrome
ea0013p102
Adolescent endocrinology; time to revisit the diagnoses? a case of septo-optic dysplasia
ea0013p103
Inherited causes and associations of medullary thyroid cancer should not be forgotten
ea0013p104
Endocrine genes are patients getting the optimum fit?
ea0013p105
Adult growth hormone replacement using a fixed graded initiation phase followed by an individualised titration phase: a single centre experience
ea0013p106
Double Y syndrome as a cause of gynaecomastia
ea0013p107
Double Y syndrome as a cause of gynaecomastia
ea0013p108
Does cyclical acromegaly exist?
ea0013p109
Multicystic dysplastic kidney a potential accelerant of complications in type I diabetes
ea0013p110
Acute presentation of pituitary stalk tumor
ea0013p111
Atypical presentation of isolated ACTH deficiency
ea0013p112
Adrenal emergencies in treated addisons disease
ea0013p113
Inheritance in autoimmune addisons: the extended family profile
ea0013p114
Comparative
Glucocorticoid metabolic pathways in human orbital adipose tissue: a comparison with subcutaneous and omental depots
ea0013p115
Genome comparison between human chromosome 19q13 and syntenic region on mouse chromosome 7 reveals loss, in man, of 5.1 Mb containing 4 mouse G-protein coupled receptors: relevance to familial benign hypocalciuric hypercalcaemia type 3
ea0013p116
Performance characteristics of an intact PTH recently developed for the Abbott Architect immunoassay analyser
ea0013p117
Cytokines and growth factors
The inter-relationship between VEGR and IGF-1 in diabetic complications
ea0013p118
Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury
ea0013p119
Comparative effects of vitamin D and EB1089 analoge in mRNA expression of parathyroid hormone-related peptide in prostate and breast cancer cell lines
ea0013p120
The peripheral actions of the des-acyl and octanoylated ghrelin on leptin in human abdominal subcutaneous adipocytes
ea0013p121
Interleukin-1alpha: the key to polycystic ovarian syndrome?
ea0013p122
Controversial interactions between TNF-alpha and IL-6 in C2 skeletal myoblast cell death
ea0013p123
The interleukine-6 −572G/C polymorphism is associated with type 1 diabetes mellitus in Russians and Tatars
ea0013p124
Growth and development
Inflammatory cytokines in juvenile idiopathic arthritis: Effects on physical growth and
in vitro
longitudinal bone growth
ea0013p125
Characterisation of parathyroid-specific transcription factor Glial Cells Missing Homolog B (GCMB) in 3 families with autosomal recessive hypoparathyroidism
ea0013p126
Neural stem cell differentiation in the injured adult mouse brain
ea0013p127
Growth in Growth Hormone (GH) deficient dwarf rats is enhanced by variable dose GH treatment
ea0013p128
Pituitary tumor transforming gene (PTTG), separase and Rad21 in neural cell growth
ea0013p129
The effects of lipid-supplemented total parenteral nutrition (TPN) on hepatic and lipoprotein lipase activity in a premature neonatal piglet model
ea0013p130
Basal gene expression patterns in children with growth hormone deficiency or Turner Syndrome
ea0013p131
An intronic growth hormone receptor mutation causing activation of a pseudoexon is associated with a broad spectrum of growth hormone insensitivity phenotypes
ea0013p132
The mosaic pattern of 21-OHase/LacZ transgene expression changes during organogenesis and growth of the adrenal cortex
ea0013p133
Growth hormone replacement therapy-importance of age and sex on pre-treatment IGF-1 and responses to growth hormone therapy-reviewing age, do the 60+ require less growth hormone replacement?
ea0013p134
Diabetes, metabolism and cardiovascular
US Mexico border diabetes prevention and control project
ea0013p135
Combination therapy with pioglitazone and losartan provides additional renoprotection in subjects with type 2 diabetic nephropathy
ea0013p136
Management of gestational diabeties in a DGH setting
ea0013p137
Dexamethasone administration does not alter serum visfatin concentrations in overweight and obese individuals
ea0013p138
Acute glucose-induced hyperinsulinaemia during oral glucose tolerance test does not affect serum visfatin concentrations
ea0013p139
Proactive care planning in diabetes: The benefit of enhanced primary and secondary care interaction
ea0013p13^
cDNA expression profiling studies reveal 7 differentially expressed genes on mouse chromosome 7 that may influence renal calcification in C3H/HeH inbred mice
ea0013p140
Expression and regulation of KiSS-1 in adipose tissue: Are kisspeptins adipokines?
ea0013p141
Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
ea0013p142
Metabolic responses to ghrelin infusion in patients with anorexia nervosa (AN)
ea0013p143
Skeletal muscle infarction: an uncommon complication of poorly controlled diabetes mellitus
ea0013p144
Aldosterone-induced upregulation of urate transporter 1 may be responsible for hyperuricemia
ea0013p145
Evaluation of impaired glucose tolerance group education sessions
ea0013p146
Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum
ea0013p147
A prospective randomised controlled trial of lifestyle intervention on quality of life and cardiovascular risk score in patients with obesity and type 2 diabetes
ea0013p148
Metabolic cage studies reveal that mice require 5 days for acclimatisation: establishing normal urinary and blood biochemistry values in BALB/c and C3H/HeH inbred mouse strains
ea0013p149
Bcl-2 upregulation mediates the protective effect of fluvastatin against oxidative damages in human vascular endothelial cells
ea0013p150
Comparison of the effects of cannabinoid receptor modulation in human primary preadipocytes and a murine cell line
ea0013p151
Effect of SOM230 on the proliferation of adult human vascular endothelial cells
ea0013p152
Relation of amniotic fluid C-peptide and insulin level to neonatal macrosomia
ea0013p153
Burden of Diabetes and its complications (based on recent decade studies) in Iran in year 2000
ea0013p154
Sodium valproate monotherapy increases ovarian hyperandrogenism but does not affect arterial compliance in young women with epilepsy
ea0013p155
Reliability on clinical features or GAD antibody measurements which is better for diagnosis of LADA?
ea0013p156
Prevalence of abnormal liver function tests in patients with diabetes mellitus
ea0013p157
Modification of insulin receptor exon 11 alternative splicing by antisense oligonucleotides
ea0013p158
The interactions between insulin and tumour necrosis factor-alpha in human aortic endothelial cells
ea0013p159
Immunohistochemical localisation of 11β-hydroxysteroid dehydrogenase type 1 in murine pancreatic islets
ea0013p160
HDL cholesterol levels are positively associated with testosterone and are lower with shorter androgen receptor CAG repeat lengths in men with Type 2 diabetes
ea0013p161
The importance of gene repression for metabolic regulation in human fat
ea0013p162
An engineered zinc finger transcription factor that activates the endogenous human insulin gene in non β cells
ea0013p163
DHEA but not DHEAS exerts anti-glucocorticoid action in human preadipocytes
ea0013p164
Bone marrow stem cells differentiating along the adipogenic lineage show marked up regulation of the adenosine A1 receptor transcript
ea0013p165
The effects of glucocorticoids on the expression of gluconeogenic and lipogenic enzymes in a rodent model of Cushings Syndrome
ea0013p166
11β-Hydroxysteroid dehydrogenase-1: key regulator in oxysterol metabolism?
ea0013p167
Usefulness of the body image assessment in obesity scale in a UK clinic population
ea0013p168
Are there multiple endogenous glucocorticoids? Chronic Effects of 5α-Tetrahydrocorticosterone in C57BL/6 Mice
ea0013p169
A case of renal artery stenosis presenting with polyuria and polydipsia
ea0013p170
Abdominal obesity is associated with a decreased hepatic mRNA expression of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in patients with non-alcoholic steatohepatitis (NASH)
ea0013p171
Type 2 diabetes mellitus presenting with diabetic ketoacidosis
ea0013p172
Approaches to recapitulating development of the endocrine pancreas using mouse embryonic stem cell
ea0013p173
Identification of orexin receptors in brown adipocytes: functional effects of orexin-B
ea0013p174
The calcium-sensing receptor is functionally expressed in human vascular smooth muscle cells
ea0013p175
Reduced telomere length, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian male type 2 diabetic patients
ea0013p176
The human orexin receptor type 2 gene: Alternative promoters determining tissue-specific expression and identification of alternate splice variants and altered translational activities
ea0013p177
Abnormalities in lipogenesis and lipolysis in Mice Lacking Hexose-6-Phosphate Dehydrogenase (H6PDH)
ea0013p178
A characterisation of novel lipase expression and glucocorticoid regulation of lipolysis in human adipose tissue
ea0013p179
Comparison of cardiovascular risk markers in patients with complete androgen insensitivity (CAIS) and premature ovarian failure (POF)
ea0013p180
TRB3: A mechanism for glucocorticoid induced insulin sensitisation in human adipocytes
ea0013p181
Insulin treatment of patients with cystic fibrosis and impaired glucose tolerance arrests the decline in pulmonary function
ea0013p182
Depot-specific activity of NFκB and JNK in human abdominal subcutaneous and omental adipose tissue
ea0013p183
Incidence, awareness and apparent symptoms of hypoglycaemia in patients with cystic fibrosis treated with insulin
ea0013p184
Circulating levels of ghrelin and leptin in ANCA-associated vasculitis
ea0013p185
Mitochondrial genes related to energy homoeostasis are dysregulated in obesity and type 2 diabetes in human adipose tissue
ea0013p186
The prevalence and detection of vitamin d insufficiency in Asian patients with type 2 diabetes
ea0013p187
IDF but not ATPIII predicts the presence of ischaemic heart disease
ea0013p188
Quality of life in women attending a patient-centred, nurse-led endocrine clinic for management of polycystic ovary syndrome
ea0013p189
Quality of life in polycystic ovary syndrome: Positive changes in women attending a patient-centred, nurse-led endocrine clinic
ea0013p190
Renal effects of ACTH: functional and microarray studies in the mouse
ea0013p191
Use of Octreotide in the dumping syndrome Diabetes mellitus or disordered insulin secretion a diagnostic dilemma?
ea0013p192
Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese children
ea0013p193
Hirsutism in PCOS Therapeutic dilemmas…
ea0013p194
Apoprotein B and the likelihood of myocardial infarction among persons with reduced kidney function in the U.S. population: the third national health and nutrition examination survey (NHANES III)
ea0013p195
An assessment of some lung function parameters in Nigerian males with diabetes mellitus
ea0013p196
Endocrine tumours and neoplasia
Does the degree of tumour shrinkage by pre-operative treatment with lanreotide affect the surgical success in acromegaly caused by pituitary macroadenoma?
ea0013p197
An unusual phaeochromocytoma crisis presenting with profound hypoglycaemia and subsequent hypertension
ea0013p198
Pituitary apoplexy: an experience from a tertiary care institution in south india
ea0013p199
Genetic background influences expression of Multiple Endocrine Neoplasia type 1 (MEN1) mutation, implicating a role for genetic modifiers
ea0013p19^
Bone metastases in papillary carcinoma thyroid and the role of I-131 ablation
ea0013p200
Pheochromocytoma- an experience from a south indian referral center
ea0013p201
Impact of the implementation of European consensus guidelines on the management of differentiated Thyroid Cancer
ea0013p202
Multiple endocrine neoplasia Type 1 (MEN1) caused by a novel mutation in intron 9 in a family with the McCune-Albright syndrome
ea0013p203
Endogenous MC4R receptors couple to multiple MAPK pathways in hypothalamic cell lines
ea0013p204
AMEND Young Investigator's Award
Ghrelin, a proliferative agent in the pituitary, inhibits AMPK (AMP-dependent protein kinase), an emerging regulator of cell proliferation and metabolism
ea0013p205
Metaiodobenzylguanidine scintigraghy (MIBG) and familial screening are not useful in phaeochromocytoma
ea0013p206
The effect of lanreotide autogel on insulin resistance, β-cell function and related metabolic variables in acromegaly
ea0013p207
An audit of chromogranin requests at a tertiary neuroendocrine referral centre
ea0013p208
Insulinoma- A complicated presentation in a rare case scenario
ea0013p209
Routine preoperative venous sampling is not necessary in aldosterone producing adenoma (Conns syndrome)
ea0013p210
Successful pregnancy and delivery after total hypophysectomy
ea0013p211
No change in brain natriuretic peptide levels after parathyroidectomy for primary hyperparathyroidism
ea0013p212
The sodium iodide symporter (NIS) is repressed by PTTG via the human NIS upstream enhancer (hNUE)
ea0013p213
Optimal strategy for the localisation of biochemical proven insulinomas
ea0013p214
Post-partum hypoglycaemia; a rare presentation of insulinoma
ea0013p215
Endoscopic pituitary surgery for acromegaly Benefits of a specialist service
ea0013p216
Value of early post-operative growth hormone assessment in acromegaly surgery
ea0013p217
Steroid cell tumour of ovary presenting with virilization in patient with suspected Polycystic ovarian syndrome
ea0013p218
Testicular teratoma, testicular seminoma and papillary thyroid carcinoma occurring in a single individual: a report of two unrelated cases
ea0013p219
Diagnosing early acromegaly: the pre-test probability of disease is strongly influenced by the presence or absence of other associated diseases
ea0013p220
Low penetrance of symptomatic or occult phaeochromocytoma/paraganglioma in a large kindred of subjects with a point mutation (268C>T) in exon 3 of the SDHB gene
ea0013p221
Assessment of the efficacy and toxicity of 131I-metaiodobenzylguanidine (131I-MIBG) therapy for metastatic carcinoid tumours
ea0013p222
Ectopic ACTH-management difficulties
ea0013p223
Clinical impact of thyroglobulin epitope recognition pattern in patients with differentiated thyroid carcinoma and positive thyroglobulin antibodies
ea0013p224
Evaluation of acromegaly status following surgery by OGTT, GH day curve and IGF-I: relationships between these parameters
ea0013p225
Neuroendocrinology and behaviour (including pituitary)
Annexin 1 interaction with calpain: a role in apoptosis
ea0013p226
Malignant prolactinoma presenting as nasal polyp
ea0013p227
The novel broad-spectrum somatostatin receptor agonist SOM230 (Pasireotide), blocks the adrenalectomy-induced increase in mitotic activity in male rat anterior pituitary
ea0013p228
The effects of radiotherapy on neurocognitive function in patients treated for non-functioning pituitary adenoma
ea0013p229
The AVP precursor, Copeptin, predicts the severity of acute and prolonged traumatic brain injury (TBI)
ea0013p230
A prospective longitudinal study of anterior pituitary dysfunction following traumatic brain injury
ea0013p231
Relaxin-3 stimulates the stress axis
ea0013p232
Co-cultures of pituitary lactotrophs and folliculostellate cells stimulates connexin 43 expression: a novel role for the nucleoside adenosine
ea0013p233
Effects of neurotensin and/or morphine on gene expression of mu and delta opioid receptor
ea0013p234
Growth hormone sensitivity in GH deficient (GHD) hypopituitary adults is dependent on gender, but independent of timing of onset
ea0013p235
PYY
336
produces an acute anorexigenic effect followed by a later orexigenic effect not seen with other anorexigenic peptides
ea0013p236
A putative role for 11β-Hydroxysteroid dehydrogenase 1 in the regulation of cerebrospinal fluid dynamics
ea0013p237
The effect of exogenous estradiol administration on working memory in the ovariectomised female hooded-lister rat
ea0013p238
I am rare Turner mosaic Can I have a baby?
ea0013p239
Traumatic brain injury and hypopituitarism
ea0013p240
Late development of secondary resistance to cabergoline in a patient with a lactotroph adenoma
ea0013p241
Subclinical hypothyroidism is associated with increased cardiovascular risk: A meta-analysis
ea0013p242
Use of the dexamethasone-suppressed corticotrophin-releasing hormone test to predict cure in patients with cushings disease following pituitary surgery
ea0013p243
Non-surgical cerebro-spinal fluid rhinorrhea in invasive macroprolactinoma: incidence, radiological and clinicopathological features
ea0013p244
Phosphorylation of MAPK family proteins by C-type natriuretic peptide (CNP) in LbetaT2 gonadotrophs a novel cyclic GMP-independent effect?
ea0013p245
A subnormal peak cortisol response to stimulation testing does not predict a subnormal cortisol production rate (CPR)
ea0013p246
Sleep disorders and response to treatment in the Acromegalic cardiovascular and respiratory outcomes with primary analogue therapy (ACROPAT) trial
ea0013p247
RNA interference as a therapy for a model of Cushings disease
ea0013p248
Sleep disorders in craniopharyngioma patients a preliminary report
ea0013p249
Small vessel remodelling and impaired endothelial-dependent dilatation in subcutaneous resistance arteries in patients with acromegaly
ea0013p250
Upward resetting of osmostat rare or under diagnosed?
ea0013p251
AIP and familial acromegaly
ea0013p252
Reproduction
Successful pregnancy in a pure gonadal dysgenesis with karyotype 46, XY patient (Swyers syndrome)
ea0013p253
Ghrelin is reduced in women with polycystic ovary syndrome and correlates inversely with HOMA IR and testosterone
ea0013p254
Audit of the Polycystic Ovary Syndrome (PCOS) Nurse led weight management clinic
ea0013p255
Differential causes of hypertriglyceridaemia and low HDL-cholesterol in women with polycystic ovary syndrome
ea0013p256
Expression of the Anti-Mullerian hormone type II receptor (AMHRII) and related Smads in human ovarian follicles
ea0013p257
The androgen receptor CAG repeat polymorphism is associated with serum testosterone levels and obesity in men with Type 2 diabetes
ea0013p258
Use of long-acting intramuscular testosterone undecanoate depot (Nebido) in men with organic severe hypogonadism: initial experience from a UK tertiary referral centre
ea0013p259
Serum anti-mullerian hormone is elevated in girls with exaggerated adrenarche
ea0013p260
Measurement of peak and trough testosterone levels during treatment with Testogel
ea0013p261
IGFBP-3 has both IGF-dependent and independent effects on cytotrophoblast proliferation in the human placenta
ea0013p262
EP
2
-mediated reduction of oxytocin-induced activity in term pregnant human myometrium
ea0013p263
Retinol binding protein 4 suppresses during normal pregnancy an inverse relationship with insulin resistance
ea0013p264
Expression of the IGF system in the involuting bovine uterus
ea0013p265
Steroids
A case of Addisons disease associated with hypogonadotrophic hypogonadism
ea0013p266
Identification of a novel, point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor-α (hGRα) gene and molecular characterization of the mutant receptor hGRαF737L
ea0013p267
A case of cured late-onset congenital adrenal hyperplasia
ea0013p268
What factors influence serum testosterone levels when initiating Nebido
®
?
ea0013p269
Establishing a reference range for urine cortisol:creatinine ratio
ea0013p270
A new source of ectopic ACTH
ea0013p271
A central physiological role for attenuated circulating DHEAS levels in aged female Rhesus Macaques?
ea0013p272
Aldosterone induces collagen synthesis
via
activation of ER1/2 in renal proximal tubular epithelial cells
ea0013p273
A life threatening presentation of addisons disease
ea0013p274
Genetic variation at the CYP11B locus accounts for heritabilities of aldosterone excretion and 11-beta hydroxylase activity
ea0013p275
ACTH insensitivity syndromes; rare causes of glucocorticoid deficiency we should not forget
ea0013p276
The effect of septic serum on adenylyl cyclase and adrenocortical responsiveness
in vitro
and
in vivo
ea0013p277
Testosterone and frailty in ageing men
ea0013p278
Comparison of 24 hour urine free cortisol measurement and hydrocortisone day curve in the assessment of hydrocortisone replacement in hypoadrenal patients
ea0013p279
Subclinical Addisons disease
ea0013p280
An adrenal coming full circle
ea0013p281
Acute improvement in insulin sensitivity by PPARgamma-agonists is not mediated by inhibition of glucocorticoid action in humans
ea0013p282
Regulation of insulin signalling across differentiation and following glucocorticoid treatment in human skeletal myocytes
ea0013p283
Identification of novel modulators of glucocorticoid sensitivity
ea0013p284
Does ginseng ingestion influence salivary testosterone and DHEA levels in females
ea0013p285
Effect of Glycaemic index of the diet on salivary cortisol and testosterone levels in females
ea0013p286
Unusually mild phenotypic presentation in a family with CYP17A1 deficiency detected by urinary steroid profiling
ea0013p287
Glucose-6-phosphate disposal and regulation of 11β-hydroxysteroid Dehydrogenase type 1: A new link between cellular glucose metabolism and the HPA axis
ea0013p288
Is the rate of fall in total testosterone steeper among men in the eighth decade of life?
ea0013p289
Glucocorticoid treatment and the consequences in adults with congenital adrenal hyperplasia
ea0013p290
The effects of glucocorticoids on the expression of gluconeogenic and lipogenic enzymes in a rodent model of Cushings Syndrome
ea0013p291
Thyroid
The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1
ea0013p292
Persistent hypothyroidism despite optimal therapy: time to rethink
ea0013p293
Thyroid storm precipitated by trauma: a rare presentation with right heart failure and liver dysfunction
ea0013p294
An audit of radioiodine treatment for thyrotoxicosis in a large district hospital
ea0013p295
Removal of tick box for TFT in pathology request forms reduces TFT performed during acute medical admission
ea0013p296
Pendred syndrome;a comparison between new and old diagnostic approaches
ea0013p297
Assessment and management of non-compliant hypothyroid patients: the role of weekly observed thyroxine therapy
ea0013p298
T3:TRAB ratio predicts patients with Graves thyrotoxicosis who cannot be controlled with antithyroid drug therapy and relapse at 2 years
ea0013p299
Chronic leg rash in Graves disease, not always pretibial myxedema
ea0013p300
The scope of cardiac complications of thyrotoxicosis in Lagos, Nigeria
ea0013p301
The outcome of the management of subclinical hyperthyroidism: Use of fixed dose of radioiodine therapy
ea0013p302
W546X mutation of the thyrotropin receptor, cause of subclinical hypothyroidism (SH) in various clinical settings
ea0013p303
Can neonatal TSH screening detect trends in population iodine intake?
ea0013p304
Seaweed as a model for iodide accumulation and storage
ea0013p305
Outcome of radio-active iodine treatment for thyrotoxicosis in Glan Clwyd Hospital 20032005
ea0013p306
Can parathyroid hormone (PTH) levels be useful in predicting postoperative hypocalcaemia in patients undergoing total thyroidectomy?
ea0013p307
Stridor as the initial presentation of large retrosternal goitre
ea0013p308
An audit of radio active iodine treatment in the management of thyrotoxicosis at a district general hospital
ea0013p309
Retrospective analysis of radioactive iodine (I
131
) treatment for hyperthyroidism
ea0013p310
A case of Burkitts lymphoma of the thyroid presenting as myxoedema coma
ea0013p311
Using an increased fixed dose of
131
I (600MBq) leads to improved outcome in patients with hyperthyroidism
ea0013p312
Effects of neurotensin and/or morphine on gene expression of mu and delta opioid receptor
ea0013p313
Only one in four patients with suspicious thyroid cytology (THY3) has a thyroid carcinoma
ea0013p314
Subclinical hyperthyroidism in cats
ea0013p315
Does synthetic thyroid extract work for everybody?
ea0013p316
Routine screening for thyroid disease in patients with diabetes mellitus: is it worthwhile?
ea0013p317
Assessment of catecholamines in patients with simple nodular goiter
ea0013p318
Retrospective analysis of radioiodine therapy for thyrotoxicosis with a 550Mbq dose
ea0013p319
Thyroid function testing in hypothyroid women during pregnancy
ea0013p320
Central arterial stiffness in resistance to thyroid hormone
ea0013p321
Audit of follow-up after radio-iodine treatment for hyperthyroidism in East and North Hertfordshire NHS Trust
ea0013p322
The unrecognised use of alternative treatments for thyroid disorders
ea0013p323
Management of thyroid nodules Local experience at a district general hospital in UK
ea0013p324
Preliminary evidence for association of PTPN12 with Graves ophthalmopathy
ea0013p325
Thyrotoxicosis complicating a molar pregnancy
ea0013p326
RET proto-oncogene exon 11 germline mutations in patients with medullary thyroid carcinoma
ea0013p327
T3 rather than TSH mediates the effects of altered thyroid status on bone turnover in man
ea0013p328
Thyroid eye disease: adjusting to an altered sense of identity influences patients interactions with healthcare professionals
ea0013p329
Plasminogen activators in human thyroid follicular cells
ea0013p330
Hypoxia inducible factor (HIF-1α) in thyroid carcinoma cell lines
ea0013p331
Propylthiouracil induced foetal goitre: a food for thought
ea0013p332
Neuropsychological abnormalities in overt and sub-clinical hypothyroidism improve but do not normalise following 3 months replacement with L-thyroxine
ea0013p333
Severe thyroid orbitopathy and ocular myasthenia gravis. A challenging case, and review of the literature
ea0013p334
Effect of methimazole on the immunoreactivity of recombinant thyroid peroxidase
ea0013p335
Role of Liothyronine in thyroid replacement therapy a retrospective audit
ea0013p336
Should long-term continuous anti-thyroid drug therapy be included in the therapeutic armamentarium for hyperthyroidism?
ea0013p337
The relative level and predictors of osteoporotic fracture in patients with treated thyroid dysfunction
ea0013p338
Weekly thyroxine administration: a safe method to administer thyroxine when compliance issues arise
ea0013p339
Pyogenic thyroiditis with hyperthyroxinaemia
ea0013p340
The relationship between serum TSH levels and blood pressure in a population sample with normal thyroid function
ea0013p341
Hyperemesis gravidarum and gestational hyperthyroidism
ea0013p342
Novartis Prize posters
Steroidogenic gene transcription in the human hippocampus and cerebellum: a comprehensive survey
ea0013np1
Kisspeptin-54 potently stimulates luteinising hormone release during the preovulatory phase of the menstrual cycle in healthy human females
ea0013np2