Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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Society for Endocrinology BES

Oral Communications

Novartis Clinical Endocrinology Award

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Young Endocrinologist prize session
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Novartis Basic Endocrinology Award

ea0013oc17 | Novartis Clinical Endocrinology Award | SFEBES2007

Kisspeptin-54 potently stimulates luteinising hormone release during the preovulatory phase of the menstrual cycle in healthy human females.

Chaudhri Owais , Dhillo Waljit , Thompson Emily , Murphy Kevin , Salem Victoria , Patterson Michael , Donaldson Mandy , Amber Vian , Ramachandran Radha , Nijher Gurjinder , Kokkinos Alexander , Ghatei Mohammad , Bloom Steve

Kisspeptin, the endogenous ligand of the GPR54 receptor, is a key regulator of the hypothalamo-pituitary-gonadal (HPG) axis. GPR54-null mice exhibit reproductive dysfunction and exogenous kisspeptin potently stimulates the HPG axis in rodents, primates and human males. The effects of kisspeptin administration to human females are not known.Aim: To investigate the effects of kisspeptin on luteinising hormone (LH) release during the menstrual cycle in fema...
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ea0013oc18 | Novartis Clinical Endocrinology Award | SFEBES2007

Sedlin mutations disrupt interactions with pituitary homeobox 1 (Pitx1) and steroidogenic factor 1 (SF1): potential cause of delayed puberty in boys with Spondyloepiphyseal dysplasia tarda (SEDT)

Jeyabalan Jeshmi , Andrew Nesbit M , Ingraham Holly A , Thakker Rajesh V

Delayed puberty may occur in some boys affected with X-linked Spondyloepiphyseal dysplasia tarda (SEDT), which is caused by mutations of the gene encoding a 140 amino acid protein designated Sedlin. Sedlin interacts with the pituitary homeobox 1 (Pitx1) and steroidogenic factor 1 (SF1) transcription factors, which are involved in the development and regulation of the hypothalamic-pituitary-gonadal axis. We have therefore investigated the hypothesis that SEDT associated mutatio...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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