Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES

Oral Communications

British Thyroid Association Award

ea0013oc34 | British Thyroid Association Award | SFEBES2007

Monocarboxylate transporter 8 (MCT8) represses proliferation of fetal embryonal NT2 and placental JEG-3 cells in vitro

James Sally , McCabe Christopher , Reaves Barbara , Smith Vicki , Chan Shiao , Barrett Timothy , Kilby Mark , Franklyn Jayne

Thyroid hormones play vital roles in fetal brain development. Mutations in MCT8, recently recognised as a specific thyroid hormone transporter, define a novel syndrome of severe X-linked psychomotor retardation and thyroid hormone resistance.N-TERA-2 (NT2) cells (human embryonal cells with characteristics of CNS precursors) were transiently transfected with either WT MCT8 or its L471P, R271H or S448X mutations, described in males affected by severe psych...

ea0013oc35 | British Thyroid Association Award | SFEBES2007

A prothrombotic clot structure in hyperthyroidism: A mechanism for increased thrombosis in hyperthyroid individuals?

Ajjan Ramzi , Orme Steve , Standeven Kristina , Phoenix Fladia , Hundia Vikram , Grant Peter

Background: Hyperthyroidism is associated with an increased risk of atherothrombosis and venous thrombotic events by mechanisms that are not fully understood. Previous work has shown that blood clot structure determines the susceptibility to thrombosis and therefore the aim of this study was to investigate the effects of hyperthyroidism on clot structure and fibrinolysis.Methods: Six patients with hyperthyroidism were included in a pilot longitudinal stu...

ea0013oc36 | British Thyroid Association Award | SFEBES2007

Comparsion of the NFκB and JNK mediated inflammatory mechanisms for production of adipocytokines in paired human epicardial and gluteo-femoral adipose tissue from CABG patients

Baker Adam R , Harte Alison L , da Silva Nancy F , Hill Margaret J , Ranasinghe Aaron , Khunti Kamlesh , Davies Melanie J , Pagano Dominico , Bonser Robert , Kumar Sudhesh , McTernan Philip G

Adipose tissue (AT) distribution impacts directly on type 2 diabetes and cardiovascular disease risk, however few studies have investigated the site-specific nature of human epicardial AT compared with gluteo-femoral (thigh) fat. Our recent studies have implicated epicardial AT as an important source of pro-inflammatory cytokines which may impact on myocardial function. Therefore the aim of this study was, using matched paired epicardial AT and gluteo-femoral (thigh) AT from p...

ea0013oc37 | British Thyroid Association Award | SFEBES2007

Testosterone replacement attenuates fatty streak formation and improves the HDLC profile in the Tfm mouse: an effect which is independent of the classical androgen receptor

Nettleship Joanne E , Jones Richard D , Channer Kevin S , Jones Hugh T

Research indicates that low testosterone is associated with CAD in men. Evidence suggests that men with hypotestosteronemia and concomitant CAD may benefit from physiological testosterone replacement therapy (PTRT). The mechanism by which testosterone produces these cardio-protective effects and the role of the androgen receptor remains largely unknown. The aim of this study was to determine whether testosterone modulates atheroma formation via its classical signalling ...

ea0013oc38 | British Thyroid Association Award | SFEBES2007

The novel thyroid hormone derivative 3-iodothyronamine increases food intake via the hypothalamic arcuate nucleus

White Nicholas , Dhillo Waljit , Bewick Gavin , Gardiner James , Scutt James , Thompson Emily , Kokkinos Alexander , Armstrong Alan , Ghatei Mohammad , Bloom Stephen

3-iodothyronamine (T1AM) is a novel, endogenous rapid acting biogenic amine, which is a potent agonist of the G-protein coupled trace amine-associated receptor 1, TAAR1. It has been suggested that endogenous T1AM could be generated by enzymatic deiodonation and decarboxylation of T4. The presence of T1AM in rat brain and the distribution of the TAAR1 receptor in the hypothalamus suggest that T1AM may affect food intake and regulate e...