Endocrine Abstracts

Objective: To evaluate the relation between C-peptide and insulin in amniotic fluid with macrosomia.

Methods and materials: We enrolled ten newborns with more than 4000 gr weight as the case-group and 28 newborns with less than 4000 gr as the control group. During delivery (C/S or NVD) about 10cc of amniotic fluid was taken and we took samples from umbilical cord or venous blood of newborn and venous blood of mothers for evaluation of insulin and C-peptide and glucose.

Results and discussion: Serum c-peptide in newborns with macrosomia (P=0.0444) and their mothers (P=0.034) were significantly higher than controls.

Amniotic fluid C-peptide in macrosomia and also insulin in venous sample of mothers with macrosomic newborns are higher but not significant.

Insulin in AF in macrosomia in higher than controls but its level is lower than C-peptide that could be due to secretion of insulinase from placenta.

Conclusion: This study showed that there is a relation between elevated C-peptide of AF, newborn blood and mother blood with increasing the weight of the fetus.