Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 13 P309

SFEBES2007 Poster Presentations Thyroid (51 abstracts)

An audit of radio active iodine treatment in the management of thyrotoxicosis at a district general hospital

S Rangan , AA Tahrani , D Ghosh , P Pickett , AF Macleod & PK Moulik

Royal Shrewsbury Hospital, Shrewsbury, United Kingdom.

Aim: To audit radioactive iodine (RAI) treatment.

Methods : A retrospective audit of thyrotoxic patients, who attended the one-stop RAI clinic, between April 2005 and February 2006.

Results: We included 74 patients (60 females, 14 males) with a median age 54 (22–85) years.

Before RAI: Smoking history was recorded in 19/74(26%) patients. 44/74(59%) patients received drug treatment for two years or more prior to RAI. Graves’ disease constitutes most cases (43/74, 58%). 18/74(24%) patients had evidence of eye disease. Treatment was block and replace in 12/74(16%) patients and dose titration in 62/74(84%).

Post RAI: All patients received 540 mBq 131I. The first thyroid function test (TFT) was done after 13–210 (median 48) days. However, the first TFT was done within three months in 64/74(86%) patients. The first outpatient appointment was after a median 68(24–365) days. 58/74(78%) patients were seen in outpatient within 3 months. Another 14(19%) were seen between 3 and 6 months post RAI and 2(3%) were not seen in outpatients. 40/74(54%) developed hypothyroidism. 22/40(56%) developed hypothyroidism within 3 months of RAI and 37/40(95%) within 6 months post RAI. There was no significant difference in the development of hypothyroidism post RAI between patients who had ATD titration or block and replace (P=0.34).

Conclusions: RAI was effective in treating thyrotoxicosis. Although most patients had TFTs and follow-up within three months post RAI, more efforts needed to ensure all patients have TFTs and reviewed within 8 weeks post RAI. Attention to smoking history is need as smoking is a known risk factor of thyroid eye disease.

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