Endocrine Abstracts

Introduction: Cushing disease (CD) is a condition due to an ACTH-secreting pituitary adenoma that is usually a microadenoma. Seldom, the lesion may be atypical by his size or his radiological aspect.The aim of this study is to analyze the clinical and biological data of CD with atypical radiological aspect (macroadenoma or other), to compare them to those of CD with a typical radiological aspect (microadenoma) and to determine the clinical or biological ...

The overall incidence of carcinoid tumors has been estimated to be 1 to 2 cases /100000 people in USA. Carcinoid tumors habitually accounts for 1% of all cases of Cushing’s syndrome. The authors report an unusual case of ectopic secretion of corticotropin from pulmonary carcinoid tumor.A. F. is a 29 years old patient who has been referred for hypercorticism with patent features including trophical signs and severe depression.L...

Pituitary enlargement with long standing hypothyroidism is well established.The clinical evolution of pituitary hyperplasia to thyroid hormone should be monitored closely during primary hypothyroidism because of the rare possibility of an incidental non thyrotropic pituitary tumor that will not regress on thyroid hormone. We report a case of a pituitary mass not responding to thyroid hormone therapy.A 46 years old women was admitte...

Most macroprolactinomas are responsive to dopamine against drugs. Bromocriptine (BRC) has been available and extensively used in our country. The aims are to assess the outcome in 29 patients with macroprolactinomas who were treated with BRC.Material and methods: A multicentric study of 29 patients with macroprolactinoma (19 female; 10 males). The mean age was 33 years. The pituitary mass was larger than 10 mm in diameter. There was no endocrinological e...

Objective: The objective of our study is to describe the lipid parameters of pregnant women with diabetes during the three trimesters of pregnancy.Materials and methods: This is a retrospective study that looked at 44 diabetic pregnant women. Clinical biological data were collected from medical records. The personal history of dyslipidemia, pathologies, and medications that may interfere with lipid parameters have been eliminated.R...

Low-grade gliomas are the most common brain tumor in children, accounting for 30–50% of central nervous system tumors in the pediatric age group. They can occur anywhere within the central nervous system (CNS) including the optic pathway (5%). When optic gliomas involve the hypothalamus, patients will often present endocrinopathy. Signs of such involvement can include growth failure and precocious puberty. In this report, we present the case of 8 years three months girls ...

Hypohidrotic ectodermal dysplasia (HED) is a rare genetic disorder characterized by the faulty development of the ectodermal structure, resulting in most notably anhydrosis/hypohydrosis, hypotrichosis and hypodontia. Affected individuals tend to have sparse scalp and body hair (Hypohidrotic), absent teeth (hypodontia) or small and pointed teeth. HED is associated with distinctive facial features including a proeminent forehead, thick lips, and flattened bridge of the nose. The...

Diabetes in paraneoplastic Cushing is often severe with a risk of acute metabolic complications.Observation n° 1: A 36-year-old patient, with no medical history, was hospitalized for inaugural diabetic ketoacidosis with no intercurrent infection. The physical examination found facio-truncal obesity, amyotrophy of extremities, melanoderma, arterial hypertension and severe psychiatric disorders. The blood tests showed an hypokalemia at 1.9 mmol/l. Hig...

Introduction: Diabetes in the elderly is a major public health problem in Tunisia. Its prevalence increases with aging population. The aim of this study was to determine the particularities of insulin-requiring diabetes in elderly patients in hospitals.Methods: This was a retrospective cross study about insulin-treated diabetics admitted in our institute between August and October 2016 for uncontrolled diabetes. Was considered as elderly diabetic any pat...

Introduction: High blood pressure (HBP) is a public health problem because it is a major cause of global morbidity and mortality. Antihypertensive therapy has evolved significantly in recent years to reduce the number of tablets to improve adherence therapy.Purpose of our work: The purpose of our work was to estimate the risk of non-compliance with antihypertensive treatments for a population of hypertensive and diabetic patients, by using a validated ca...