Endocrine Abstracts

Hypoglycaemia in non-diabetic patients has a multitude of causes from exogenous insulin to paraneoplastic syndromes. We explore the importance of obtaining a ‘golden sample’, a serum blood sample, during the episode of hypoglycaemia, prior to reversal with treatment. The case herein describes a patient with recurrent episodes of unexplained hypoglycaemia which precipitated several hospital admissions. Standard screening tests did not detect any obvious cause for his ...

A 51-year-old woman with no significant past medical history presented with left flank pain, accelerated hypertension, progressive deterioration in renal function and left sided pleuritic chest pain. CTPA revealed pulmonary oedema and left adrenal haemorrhage. Urinary catecholamines were marginally elevated (24 h Urinary Metadrenalines 7.58 μmol/24 h) raising the possibility of an underlying phaeochromocytoma. Short synacthen test showed a sub-optimal response (0 min cort...

A 73 years old female presented in 2005 with 8 year history of face and body hirsutism. Examination confirmed hirsutism but there were no other masculinization features. Her initial investigations revealed a high testosterone of 13 nmol/l, normal androstenedione, DHEA-S and 17 hydroxy progesterone. CT and U/S of pelvis and abdomen, showed normal adrenals, ovaries and a large calcified uterine fibroid. Urinary steroid metabolites ruled out adrenal testosterone source and exogen...

An elective total thyroidectomy was performed on a previously well 45-year-old nurse for toxic multinodular goitre. The operation was uneventful and the patient was discharged. She was re-admitted two days after the operation, with paraesthesia and muscle spasms affecting the face and hands. She was found to be hypocalcaemic, corrected calcium 1.83 mmol/l. She was treated with intravenous calcium gluconate, oral calcium and 1-alpha calcidol. Parathyroid levels were undetectabl...

Introduction: The T,B and antigen presenting cells play a key role in the pathogenesis of autoimmune diseases.The aim of the studies was to analyse different regulatory cells subsets interaction in patients with Graves’ disease.Material and methods: We have studied paraffin thyroid specimens obtained from 10 children with Graves’ disease after thiamazole treatment. The thyroid tissue was stained with hematoksylin-eosin (H...

We describe an 80 year-old man with Graves’ thyrotoxicosis and thyroid orbitoapthy accompanied by ocular myasthenia gravis.He presented in 2004 with chemosis, exophthalmos, diplopia, ptosis, and restricted movements. He also gave history of weight loss (six kilograms). FT4 29, FT3 7.7 and TSH 0.04. MRI Orbits revealed swelling of the extra-ocular muscles.Ocular movement was markedly restricted but a curious feature of the pres...

We report a retrospective study of 50 cases of primary hyperparathyroidism (10 men and 40 women, mean age: 49 years) collected between 1975 and 2004. At the time of diagnosis, 44% of patients had bone disease, renal manifestations were present in 17 cases (34%).Parathyroidectomy is a safe and effective approach of primary hyperparathyroidism treatment. The management of persistent or recurrent hyperparathyroidism is explained by the fact that parathyroid...

The frequency of type 2 diabetes increases in all of the world. The risk for atherosclerosis vascular disease is greatest in type 2 diabetic patients who have other known risk factors such obesity, smoking, hypertension and dyslipidemia.The aim of our study is to determine the frequency of cardiovascular risk factors associated to diabetes and the frequency of macrovascular complications in type 2 diabetic patients.It is a retrospe...

Prolactinoma represents 27 to 35% of pituitary adenomomas and 40 to 75% of secreting adenomas. However, the macroprolactinomas are not frequent. We report clinical, biological and therapeutic aspects of 5 cases of macroprolactinomas. It concerns 3 women and 2 men. The average age is 43.4 years (19–68). The reason for seaking medical advice was amenorrhea – galactorrhea syndrom in 2 women and infertility in one case. The diagnosis of pituitary adenoma is incidentally ...

Background and aimDiabetes is the leading cause of adult blindness due to retinopathy. Serum uric acid levels independently predict the development of micro vascular complications. In this study, we analyze the relationship between serum uric acid (SUA) levels with the development and the severity of diabetic retinopathy(DR) in patients with type 2 diabetes mellitus (T2DM).Patients and MethodsA total of 100 T...