Endocrine Abstracts

Introduction: Sheehan Syndrome (SS) is a cause of hypopituitarism resulting from postpartum pituitary infarction. Its frequency is decreasing worldwide, particularly in developed countries due to advances in obstetric care. Case report: A 50-year-old female patient was admitted to the emergency department with complains of progressive pain in the lower hemithorax and abdomen. She also referred constipation, weight gain and asthenia. The initial laborator...

Background: Transition from paediatric to adult services is a crucial process for young adults with long term conditions (LTC) affecting quality of life and engagement with medical services. The recent NICE report has outlined overarching principles for an effective transition. This can be a challenge for paediatricians and adult physicians as both hospital sites and medical/nursing teams can change. There is a dearth of evidence regardin...

Background: Transition from paediatric to adult services is a crucial process for young adults with long term conditions (LTC) affecting quality of life and engagement with medical services. The recent NICE report has outlined overarching principles for an effective transition. This can be a challenge for paediatricians and adult physicians as both hospital sites and medical/nursing teams can change. There is a dearth of evidence regardin...

Case history: A 54-year-old lady was diagnosed with primary hypoparathyroidism in 2005, after being referred by her Rheumatologist as her father and brother had familial hypoparathyroidism and sensorineural deafness. She was followed up in endocrine clinic for management of primary hypoparathyroidism. Her hypocalcaemia is well managed with calcium supplementation, with no specific symptoms of hypocalcaemia. She has recurrent urinary tract infections with known borderline chron...

Background: The Covid-19 pandemic caused by the severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) determined millions of deaths worldwide, thus at the end of 2020 a massive vaccination campaign has been launched. SARS-CoV-2 infection and vaccines have been associated with several thyroid disorders, especially subacute thyroiditis (SAT), Graves’ disease (GD) and orbitopathy (GO). We studied the occurrence of SAT and GO following SARS-CoV-2 infection or vaccinati...

Introduction: The humanized antibody anti-CD52+ alemtuzumab has been approved since 2014 for the treatment of relapsing-remitting multiple sclerosis (RRMS). Immune reconstitution after alemtuzumab induces thyroid autoimmunity in 34-41% of patients with RRMS, with Graves’ disease (GD) accounting for 63-65% of cases. Graves’ Orbitopathy (GO) may also occur in 13% of patients after alemtuzumab and is scarcely reported. Here we present the first case of alemtuzumab-induc...

Despite an accurate management, in about 20% of hypothyroid patients showing an increased need for oral levothyroxine (LT4), the leading cause of treatment refractoriness remains unknown. Some studies hypothesized the relationship between gut microbiota composition and thyroid homeostasis, but the possible involvement of microflora in the efficacy of LT4 treatment has not been evaluated yet, and this represents the aim of our study. We examined the faecal microflora compositio...

Background: The dexamethasone suppression test (DST) is among essential tests for hypercortisolism diagnosis. Due to high sensitivity and specificity, liquid chromatography-tandem mass spectrometry (LC-MS/MS) is replacing obsolete immunoassays (IA) for steroid measurement. However, exhaustive data about IA and LC-MS/MS concordance in the frame of DST are still not available.Aim: To compare cortisol measurements by two routine IAs and LC-MS/MS in basal (F...

Background: Vaccination is a widely adopted measure against the severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) causing Covid-19 pandemic. Both SARS-CoV-2 infection and Covid-19 vaccines have been associated with several thyroid disorders. We studied the risk of Graves’ orbitopathy (GO) following Covid-19 vaccination.Methods: The study included 98 consecutive patients (71 females and 27 males, mean-age 50 years) attending our tertiary r...

Low vitamin D levels were consistently reported as a risk factor for worse outcomes in hospitalized COVID-19 patients. Emerging evidences suggest that in 50–70% of COVID-19 survivors several post-COVID symptoms can be observed up to 3 months after acute-disease, representing a novel clinical condition defined Long-COVID syndrome. To date, the predisposing factors for this syndrome are still poorly understood. We retrospectively aimed at evaluating the influence of 25(OH) ...