Endocrine Abstracts

Based on insights obtained during the last decade, the classical concept of an activated hypothalamus-pituitary-adrenocortical (HPA) axis in response to critical illness is in need of revision. After a brief central HPA axis activation, the vital maintenance of increased systemic cortisol availability and action in response to critical illness is predominantly driven by peripheral adaptations rather than by an ongoing centrally-activated several-fold increased production and s...

A 27 year old was referred to endocrine clinic for investigation of longstanding gynaecomastia. He had noticed loss of early morning erections. He never fully grew a beard and had no children. This was associated with temporal hair recession and intermittent headaches. On examination he appeared to be of asthenic built and youthful. He was tall with his upper body being longer than lower. He had widely spaced breasts and long arms. His testicular volume on examination was 1&#1...

Background: Leptin facilitates onset of puberty by impacting hypothalamic Kisspeptin, gonadotropin releasing hormone, follicle stimulating and luteinizing hormone. The link of peripheral Leptin-Kisspeptin in regulating the ovarian and endometrial tissue in relation to adiposity is unknown. Therefore, we wanted to identify their association with body mass index (BMI) and success of assisted reproductive treatments (ART) in infertile females.<p class="abst...

Background: Leptin facilitates onset of puberty by impacting hypothalamic Kisspeptin, gonadotropin releasing hormone, follicle stimulating and luteinizing hormone. The link of peripheral Leptin-Kisspeptin in regulating the ovarian and endometrial tissue in relation to adiposity is unknown. Therefore, we wanted to identify their association with body mass index (BMI) and success of assisted reproductive treatments (ART) in infertile females.<p class="abst...

Introduction: Denosumab, a human monoclonal antibody used in osteoporosis and second line treatment option for hypercalcaemia, can cause profound hypocalcaemia especially in Vitamin-D depleted and cancer patients.Case history: 56 years female, with diabetes, hypertension on metformin, empagliflozin, amlodipine and ramipril, presented with 3 months history of backache, no red flag signs, clinically and hemodynamically stable except mild confusion and spin...

Using nurse led clinics (including telephone and virtual reviews) in NHS Grampian to improve patient satisfaction following a diagnosis of hyperthyroidism.Aims: To reduce waiting times for patients with hyperthyroidism, nurse led clinics were introduced. Telephone and virtual follow up reviews are offered after commencement of thyroid treatment (e.g. anti-thyroid medication or radioactive iodine (RAI)). Nurse-led thyroid clinics aim to i...

Approximately 230 new patients with GEP-NEN are referred annually to the centre. Prevalence of GEP-NEN is increasing due to the availability of 2nd, 3rd or 4th line treatments. Oral chemotherapy is being used with increasing frequency in this setting. The NEN Team wished to explore the outcomes of patients treated with temozolomide singe agent and temozolomide/capecitabine during the previous 5 years and compare the findings with current literature. 18 patients were included i...

Neuroendocrine neoplasms (NENs) are a heterogeneous tumour classification including indolent neuroendocrine tumours (NETs), aggressive neuroendocrine carcinomas (NECs). NECs and small cell lung cancer (SCLCs) are poorly differentiated tumours and life expectancy following metastatic diagnosis is less than 1 year. Currently, there are known variants in germline DNA that associate with bronchial and pancreatic NENs, but not intestinal. We conducted an exome-wide association stud...

P450 Oxidoreductase (POR) deficiency is a rare autosomal recessive disorder of steroidogenesis with varied clinical presentation. POR is the electron donor for all microsomal enzymes involved in steroidogenesis namely P450c 17(17 hydroxylase/17,20 lyase), P450c 21 (21 –hydroxylase), and P450 aro(aromatase). POR deficiency can cause genital ambiguity in both sexes, impaired steroidogenesis and skeletal malformations. Here we present a patient with ovarian cysts and delayed...

Case history: A 67 year-old male was referred from GP to Endocrine clinic due to incidental high Calcium level in a routine bone profile. Adjusted Serum Calcium was 2.69 mmol/l. In Endocrine clinic, a detailed history was taken. The patient denied all symptoms of hypercalcemia.Past medical history: Alcohol-related cirrhosis (complicated with Varices banded by OGD), Diverticular disease, Type 2 diabetes mellitus, Hypertension, Hyperlipidemia.<p class=...