Endocrine Abstracts

Basic education about diabetes is a cornerstone to diabetes management but in the UK there was, until recently, no national recognised programme easily available in every Paediatric unit despite several being under development for considerable time.Children in any age group vary considerably in their ability to learn and accept new responsibilities. Diabetes education, therefore, should be adapted to the individual child’s level of development and u...

Abstract unavailable....

IntroductionA summary of developments in nursing over the past years in the specially endocrinolodical diseases. The presentation will respectively be in a nursing perspective and in a patient perspective. Furthermore it will be based on nursing for patients with acromegaly, Cushing’, Addison’ and pheochromocytoma.The results show a change in the quality of medical care for these groups of patients. It emerged from the nu...

Rhythmic change of the internal milieu is a fundamental principle in all living organisms. A variety of physiological events show daily rhythms, such as blood pressure, hormonal secretion, cell cycle, and migration of stem cells from the bone marrow to the systemic circulation. This timing is determined by the endogenous oscillatory system called the circadian clock. Within the last ten years, the molecular dissection of circadian clock has progressed dramatically, and it is n...

Craniopharyngiomas are embryogenic tumorous malformations of the sellar region, presumably derived from Rathke cleft epithelium. With an overall incidence of 0.5–2 new cases per million population per year, approximately 30–50% of all cases represent childhood craniopharyngioma. Typical manifestations at primary diagnosis are headache, visual impairment, polyuria/polydypsia, growth retardation, and weight gain.Therapy of choice in patients with...

Circadian clocks regulate the adaptation of the organism to the rotation of the earth around its axis. In mammals the circadian timing system is comprised of numerous cellular oscillators throughout the brain and the body. In the hypothalamic suprachiasmatic nucleus a circadian pacemaker is synchronized to the external light/dark cycle via direct innervation along the retinohypothalamic tract. From the SCN, peripheral clocks are synchronized by neuronal, endocrine and behavior...

The goal of this study was to determine whether ghrelin increase aromatase gene expressions and estradiol 17-β concentrations in ventromedial (VMH) and lateral hypothalamic area (LH). Forty rats were randomly divided into four groups. Animals in different groups were received either saline, 1, 2 or 4 ng ghrelin into their VMH and LH. After infusion of ghrelin, VMH and LH tissue were separated and homogenized. Homogenized sample were assayed for aromatase gene expression b...

Introduction: Severe hypoglycemia induced by sulfonylurea overdose is a result of insulin hypersecretion. Pasireotide (SOM230) is a multireceptor-targeted somatostatin analogue with high affinity for somatostatin receptor subtypes sstr1,2,3 and especially sstr5, which are expressed on rat and human β cells; pasireotide has been shown to inhibit insulin secretion in both species. The aim of these studies was to investigate the ef...

Abstract unavailable....

There is increasing recognition that pituitary adenomas may occur in a familial setting, and a number of families have been identified to have familial isolated pituitary adenoma (FIPA), without features of the MEN1 syndrome, Carney complex, or other known familial disorders. Heterozygote germline mutations were identified in a gene encoding AIP (aryl-hydrocarbon receptor interacting protein) in some FIPA families. We have characterised our unique large collection of 140 famil...