Endocrine Abstracts

In the UK 1 in 500 children will develop cancer in childhood. Survival from childhood cancer has more than doubled since the 1960s. Survivorship is increasingly on the agenda and the National Cancer Survivorship Initiative has been launched in the UK.During adolescence the endocrinologist is faced with four challenges in managing childhood cancer survivors:-1. Managing the immediate endocrine consequences of cancer therapy, in part...

Introduction: There are many reports that vascular and/or heart valve calcification is good predictor for low bone mineral density. I investigated whether benign calcification of breast can also well predict low bone mineral density.Methods/design: I have reviewed and analyzed the records of 91 women with age more than 50 years old among patients examined bone mineral density and breast mammography from January through December 2010. The lowest value of ...

The classical genomic actions of triiodothyronine (T3) are mediated by high-affinity nuclear receptors that directly regulate gene expression. By contrast, the non-genomic effects of thyroid hormones occur rapidly and are unaffected by inhibitors of transcription and protein synthesis. The genomic actions of thyroid hormone have an established role in the development, differentiation and homeostatic maintenance of target tissues. The THRA and THRB gene...

Neonatal diabetes or monogenic diabetes of infancy can manifest as a transient or permanent condition. TNDM is most commonly caused by imprinting disorders on chromosome 6q24 (TNDM1.Uniparental Isodisomy Chromosome 6, Paternal Duplication of 6q24, loss of maternal methylation). Recently it has been identified that over half of those with maternal hypomethylation at 6q24 have relaxed maternal methylation at other imprinted loci and that the majority of these patients have mutat...

Disruption of the HPT-axis during growth profoundly influences skeletal development and effects may not be reversed fully following correction of thyroid status. Adult thyrotoxicosis leads to increased bone turnover and is an established risk factor for osteoporotic fracture. The conventional view that skeletal responses to abnormal thyroid status result solely from altered T3 action in bone has, however, been questioned by studies proposing TSH as a negative regula...

A 39-year-old man was referred to the endocrinology clinic with a suspected phaeochromocytoma. He had a history of hypertension, episodic flushing and erectile dysfunction. He denied any recreational drugs abuse. His past medical history included primary hypogonadism of unknown cause and hypertension. He was on ramipril 5 mg od, atenolol 50 mg od and susatnon injections.Clinical examination was unremarkable away from BMI of 35, facial flushing and raised...

IntroductionDiabetic ketoacidosis (DKA) affects 1-3 percent of pregnancies complicated by diabetes but can result in significant morbidity and mortality for mother and foetus. Euglycaemia in DKA is a recognised but infrequent presentation. It was originally defined as initial blood glucose less than 16.7 millimol per litre and bicarbonate less than 10 millimol per litre.Case ReportA 29-year old female with ty...

IntroductionDiabetic ketoacidosis (DKA) affects 1-3 percent of pregnancies complicated by diabetes but can result in significant morbidity and mortality for mother and foetus. Euglycaemia in DKA is a recognised but infrequent presentation. It was originally defined as initial blood glucose less than 16.7 millimol per litre and bicarbonate less than 10 millimol per litre.Case ReportA 29-year old female with ty...

The GH-IGF-1 axis alters through the menstrual cycle. During the periovulatory period when oestrogen levels have risen serum growth hormone (GH) levels increase 2-fold. IGF-1 levels have been reported as unchanged or modestly increased in the periovulatory period. Similarly exogenous oestrogens also increase GH levels while IGF-1 levels have been reported as reduced, unchanged or increased. Peripheral responsiveness to GH as reflected by the IGF-1 response to an acute bolus of...

Objective: To examine immunoglobulin concentrations in the sera of children with type 1 diabetes and to compare them with those found in non-diabetic subjects.Patients and Method: Serum immunoglobulin A and D concentrations were measured by ELISA in 35 children with type 1 diabetes and 46 healthy children (younger than 15 years of age).Results: Serum immunoglobulin levels increase until the age of 15 but no sex variation has been found. Age variation of the mean immuno...