Searchable abstracts of presentations at key conferences in endocrinology

ea0014s2.2 | Hormones and the brain | ECE2007

Neuroprotective actions of estrogens in the central nervous system

Garcia-Segura Luis , Azcoitia Iñigo

Sex hormones act both as endocrine signals as well as local paracrine or autocrine factors in the nervous system. In addition to target to classical endocrine and reproductive brain areas, sex hormones and its metabolites affect learning and cognition and regulate the development and plasticity of brain regions that are not directly related to reproduction. Estrogen and progesterone exert neuroprotective effects in the central nervous system and may affect the onset and progre...

ea0014p352 | (1) | ECE2007

The use of perchlorates in the treatment of some special forms of hyperthyroidism (report of two cases)

Kun I , Szanto Zsuzsanna , Let Emilia

The perchlorates block the enzyme NIS, inhibiting iodine accumulation in the thyroid and favour the elimination of intrathyroidal iodine unused for hormone synthesis. Their therapeutical utilisation actually is limited due to the toxicity. In the literature there are different opinions regarding the adverse effects (nephrotic syndrome, irreversible aplastic anemia etc.), but several authors sustain that these appear only after high doses, and after the development of therapeut...

ea0012oc6 | Young Endocrinologist prize session | SFE2006

Subcellular distribution of thyroglobulin (Tg) and sodium-iodine-symporter (NIS) in normal thyroid, Graves’ and thyroid carcinomas using confocal microscopy

Kollecker I , von Wasielewski R , Brabant G

NIS and Tg are viewed as characteristic markers for thyrocytes. They are still expressed in a high percentage of differentiated and undifferentiated thyroid carcinomas but these data are obtained by conventional immunohistochemistry. Here we used tissue microarrays and confocal microscopy to compare subcellular localization of Tg and NIS in a large series of benign and malignant thyroid samples.Methods157 papillary (PTC), 56 follic...

ea0011s60 | Steroid hormone receptors | ECE2006

Cell membrane receptors of steroid hormones

Brosens J , Huhtaniemi I , Gellersen B

Rapid activation of diverse signal transduction pathways is thought to play an integral role in the cellular responses to many steroid hormones, including progesterone. This sex steroid is essential for normal reproduction in nearly all species. The recent cloning of a G-protein coupled receptor with the properties of a membrane progestin receptor (mPR) in fish and the subsequent identification of three mammalian homologues (mPR-alpha, -beta, and -gamma) raised the possibility...

ea0011p76 | Clinical case reports | ECE2006

Parathyroid carcinoma in a patient with chronic renal failure on long-term dialysis

Diaconescu MR , Glod M , Costea I

Background: Parathyroid carcinoma (PC) is a rare endocrine tumour, with difficult intraoperative recognition, histological diagnosis and imprevisible evolution. More unusual are the cases appearing at the patients with end-stage renal disease on maintenance hemodialysis (22 observations in medical literature).Case report: A 46 year-old man which suffered of chronic glomerulonephritis from 13 years, being on hemodialysis from three years, complains of ast...

ea0011p87 | Clinical case reports | ECE2006

Gitelman’s syndrome in pregnant, type 1 diabetic patient presented with foetal growth retardation, and bilateral hydronephrosis and hydroureter

Elrishi MA , Kilvert A , Sirnivasan B , Lawrence I

Gitelman’s syndrome (GS) is an autosomal recessive primary renal tubular disorder with hypokalemic metabolic alkalosis, hypocalciuria, and magnesium deficiency. The association of GS and type 1 diabetes is rare1, and bilateral hydronephrosis and hydroureter has not been reported.A 18-year-old female with known GS diagnosed at 17 years of age and type 1 diabetes diagnosed at 15 years of age was admitted to Leicester Royal Infirmary for pre...

ea0011p105 | Clinical case reports | ECE2006

Conn’s syndrome associated with hyperprolactinaemia: two case reports. Hypertension was cured by surgery in both cases despite a 10 and 16 year history

Talapatra I , Ghosh S , Tymms DJ

We describe two cases of Conn’s syndrome both of whom had hyperprolactinaemia of which one was associated with pituitary adenoma, possibly as part of MEN 1.The first patient was a man aged 52 who presented with hypertension present for 10 years and a marginally low serum potassium. He was on doxazosin, lisinopril, candesartan and celiprolol. His Aldosterone/Renin ratio (8500:1) was very high suggestive of primary hyperaldosteronism. The patient was ...

ea0011p245 | Cytokines and growth factors | ECE2006

The differential influence of specific plant lectins on insulin and IGFs binding to solubilised placental membrane IGF and insulin receptors

Masnikosa R , Baricevic I , Nedic O

The influence of the plant lectins on binding of IGF-I, IGF-II and insulin to the cognate receptors from solubilised human placental cell membranes was examined. The lectins (wheat germ agglutinin, WGA; concanavalin A, Con A; phytohaemagglutinin, PHA and Sambucus nigra agglutinin, SNA) were chosen according to their sugar specificity and were expected to bind to the most abundant saccharides present as terminal residues on N-glycan moieties of insulin receptor (IR) and ...

ea0011p334 | Diabetes, metabolism and cardiovascular | ECE2006

Regulation of hexose-6-phosphate dehydrogenase (H6PDH) in human fetal liver WRL-68 cells

Swali A , Bujalska I , Stewart PM , Walker EA

Excessive glucocorticoid exposure has been implicated in the pathogenesis of obesity and the metabolic syndrome. The in vivo conversion of inactive to active glucocorticoids is catalysed by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), requiring NADPH as a cofactor. Hexose-6-phosphate dehydrogenase (H6PDH) is co-localised with 11β-HSD1 in the lumen of the endoplasmic reticulum and controls local NADPH availability. Thus H6PDH plays an important role...

ea0011p575 | Neuroendocrinology and behaviour | ECE2006

Association between the LRP5 gene and serum post-menopausal follicle stimulating hormone levels

Zofkova I , Zajickova K , Hill M

The LRP5 gene is believed to be primarily associated with bone metabolism via Wnt signalling. The latter pathway, however, seems to control various other systems outside the skeleton. We identified the C/T (c.4037:A1330V) polymorphism in the LRP5 gene using a restriction analysis of the PCR product in a cohort of 165 white untreated pre-and post-menopausal women. In a subset of 84 post-menopausal women we analysed the association between the LRP5 genotype and circulatin...