Searchable abstracts of presentations at key conferences in endocrinology

ea0026p711 | Diabetes (epidemiology, pathophysiology) | ECE2011

Vitamin D and gestational diabetes

Pi J , Vallina I F , Alonso F , Penuela I , Caton B , Tutor E , Santos E

Introduction: There is an increasing evidence of vitamin D role in maintaining normal glucose homeostasis. Gestational diabetes (GD) is related to insulin resistance and vitamin D deficiency has been linked with GD risk in some studies.Aims: To assess whether vitamin D levels are related with gestational diabetes in a group of healthy pregnant women.Subjects: The whole group included 845 pregnant women recruited from April 2009 to ...

ea0023p10 | (1) | BSPED2009

Defining Criteria for Poor Responders to Growth Hormone (GH) in Short Children Born Small for Gestational Age (SGA)

Omokanye A , Onyekpe I , Patel L , Banerjee I , Amin R , Hall C , Clayton P

An estimated 5% of all newborns are born SGA (weight less than −2SD at birth), with 10% failing to catch up and becoming eligible for GH treatment. Not all children respond to GH, but the criteria for determining a non-responder have not been clearly defined. We have therefore evaluated first year growth performance of short SGA children treated with GH in The Growth Clinic, Manchester. Clinical and auxological data were collected retrospectively from the case records of...

ea0011p249 | Cytokines and growth factors | ECE2006

Plasma interleukin 18 in patients with polycystic ovary syndrome – relation to insulin resistance

Kowalska I , Straczkowski M , Nikolajuk A , Kozlowska A , Karczewska-Kupczewska M , Adamska A , Wolczynski S , Kinalska I , Gorska M

Aim of the study: Polycystic ovary syndrome (PCOS) is common disease affecting women in reproductive age which leads to anovulation. In pathogenesis of PCOS insulin resistance plays an important role. The aim of the present study was to look for possible relationship between interleukin 18 (IL-18) and insulin resistance in patients with PCOS.Material and Methods: The study was done in 76 patients with PCOS and 40 women without menstrual disturbances. The...

ea0011p332 | Diabetes, metabolism and cardiovascular | ECE2006

The severity of cardiovascular disease in women is modified by estrogen receptor alpha polymorphic variants

Alevizaki M , Saltiki K , Kanakakis I , Cimponeriu A , Alevizaki C , Georgiou I , Anastasiou E

Impaired estrogen (E2) action is important for cardiovascular disease (CAD) in both men and women. Associations of CAD with estrogen receptor polymorphisms, which may influence sensitivity to E2 have been reported for men but have not been confirmed for women. The aim of the present study was to investigate the association of estrogen receptor common polymorphisms with the severity of coronary disease in women undergoing coronary angiography.Estrogen rec...

ea0005oc3 | Reproduction and Development | BES2003

Lipocortin-1 is modulated by glucocorticoids in the human endometrium

Taylor A , Bedford K , Robinson J , Richmond I , Maguiness S , Adams I , Atkin S

Lipocortin 1 (LC1) is a well-characterized anti-inflammatory, -anti mitotic and anti-proliferative member of a structurally related family of Ca2+ and phospholipid-binding proteins. LC1 is readily detectable in the neuroendocrine system by Western blot analysis, ELISA, and immunohistochemistry (1). In these tissues, glucocorticoids regulate both the expression and subcellular distribution of LC1. Other studies have also demonstrated the presence of LC1 in endometrium tissue th...

ea0005p150 | Endocrine Tumours and Neoplasia | BES2003

Expression of vascular endothelial growth factor and its receptors in human anterior pituitary adenomas

Adams I , Henderson R , Green V , Foy P , Macfarlane I , Atkin S

Vascular Endothelial Growth Factor (VEGF) is an important growth factor, simulating the process of angiogenesis which is required for tumour progression. It mainly acts through 2 receptors VEGF-R1 and VEGF-R2. Whilst the presence of VEGF has been shown in pituitary adenomas, no study has undertaken the quantification of the expression of VEGF121, VEGF165, VEGF-R1 and VEGF-R2, and whether their expression may correlate.METHODS. We have used the technique of quantitative RT-...

ea0002p49 | Genetics | SFE2001

A Case of Mu1tiple Endocrine Neoplasia Type 1 (MEN1) Caused By A New Genetic Mutation

Soran H , Murray L , Ellis I , Ellard S , English P , Jones I

Introduction: The MEN1 is inherited as autosomal dominant trait. In MEN 1 families a deletional mechanism of the regulatory gene appears to be the base of the syndrome.Case 1: 40-year-old lady presented with a two-day history of headaches, blurred vision and funny turns, culminating in loss of consciousness and a generalised tonic-clonic seizure. Her GCS was 3; she was intubated, ventilated and referred to ICU. U+Es normal, Calcium high, phosphate low, a...

ea0084ps2-08-67 | Thyroid Cancer BASIC | ETA2022

Down-regulated HSA-MIR-204-3p may identify high-risk papillary thyroid carcinoma patients

Stojanović Stefana , Selemetjev Sonja , Đorić Ilona , Jankovic Jelena , Živaljević Vladan , Tatić Svetilsav , Išić Denčić Tijana

Objectives: Finding novel tumor markers capable to recognize aggressive papillary thyroid carcinoma (PTC) forms are of great importance. We evaluated hsa-microRNA-204-3p (miR-204-3p) for differential diagnosis of thyroid tumors and assessed its prognostic usefulness.Methods: MiR-204-3p levels were determined in 77 PTC cases of diverse histological variants, 12 cases of follicular thyroid adenoma (FTA), and 89 matched nonmalignant thyroid epithelial tissu...

ea0029p1204 | Obesity | ICEECE2012

Different metabolic response to intagastric balloon treatment between non-morbid and morbid type of obesity

Nikolic M. , Mirosevic G. , Kruljac I. , Vrkljan M. , Supanc V. , Ljubicic N. , Duvnjak M. , Budimir I. , Pezo Nikolic B. , Sabol M. , Nikolac I. , Bekavac Beslin M.

BioEnterics Intragastric Balloon (BIB) is a non-invasive procedure which proved to be effective in short-term treatment of obesity. It’s effect on alterations in metabolic parameters is poorly understood. Since our previous study showed different ghrelin and leptin response between groups of morbidly (M) and non-morbidly (NM) patients after BIB placement, we aimed to investigate the alteration dynamics in metabolic parameters between these two groups.<p class="abstext...

ea0092ps2-19-08 | Thyroid Hormone Transport &amp; Metabolism Basic | ETA2023

Thyroglobulin detection in extracellular vesicles isolated from human plasma

Đorić Ilona , Janković Miljuš Jelena , Kosanović Maja , Išić Denčić Tijana , Živaljević Vladan , Selemetjev Sonja

Objective: Detecting recurrence of differentiated thyroid cancer is performed by serial measurements of serum thyroglobulin (Tg) levels, however, in the presence of anti-Tg antibodies, this measurement is unreliable. Extracellular vesicles (EVs) are small membrane-enclosed structures, with a prominent role in cell-to-cell communication. All cell types release EVs and they can be isolated from various biofluids, while their cargo reflects the content of the cell of origin. Prev...