Searchable abstracts of presentations at key conferences in endocrinology

ea0029p506 | Diabetes | ICEECE2012

Altered Mitochondrial Bioenergetics Does Not Explain Increased Ros Production In Non-Obese Asian Indians With Type 2 Diabetes (T2D)

Chattopadhyay M. , Roy I. , Baitalik D. , Mukhopadhyay S. , Chakrabarti S.

Introduction: Deranged Mitochondrial bioenergetics is a key feature of type 2 diabetes and obesity but its status in non-obese type 2 diabetes patients is not known. The aim of the present study was to assess the status of mitochondrial oxidative phosphorylation and ROS metabolism in subcutaneous adipose tissue isolated from 4 groups of subjects: non-obese subjects with type 2 diabetes (NOT2D), non-obese non diabetic (C), obese non-diabetic (OB) and obese type 2 diabetes subje...

ea0029p576 | Diabetes | ICEECE2012

The relationship between the level of knowledge of physicians on guidelines and the degree of glucometabolic control in type 2 DM patients in Turkey

Satman I , Imamoglu S , Yilmaz C , on behalf of ADMIRE Study Group

Introduction: Clinical practice guidelines on diabetes mellitus (DM) was created by The Society of Endocrinology & Metabolism, Turkey (SEMT). The ADMIRE Project is designed to evaluate the effect of implementation activities to increase physiciansÂ’ awareness on guidelines.Methods: A total of 180 physicians from national representative diabetes clinics kept medical records of 885 T2DM patients for 6 months, without any interference to their routi...

ea0029p614 | Diabetes | ICEECE2012

Blocking Notch pathway improves wound healing in diabetic mice

Sunkari V. , Botusan I. , Grunler J. , Brismar K. , Catrina S.

Aim: We have proposed to study the modulation of the Notch pathway in diabetes having in mind the essential role played by the Notch system in the regulation of cell differentiation and angiogenesis.Methods: The effect of hyperglycemia on Notch system was studied in vitro and in vivo using western blot, reporter gene assay or evaluation of target genes (qRT-PCR). The functional consequences of the Notch system modulation were studied by the...

ea0029p624 | Diabetes | ICEECE2012

Pattern of chronic complications among Nigerian patients with DM: the need for focused prevention initiatives

Kayode O. , Odukoya O. , Odeniyi I. , Fasanmade O. , Ohwovoriole A.

Introduction: The prevalence of diabetes mellitus among Nigerian adults has been increasing over time. A considerable number of chronic complications of DM can be adequately prevented, however, the proportion of patients presenting with chronic complications of DM in our setting is still relatively high.Objectives: This study was carried out to assess the pattern of chronic diabetic complications among patients attending the diabetic clinic of Lagos Univ...

ea0029p669 | Diabetes | ICEECE2012

The Loss of Work Productivity in Type 2 Diabetes Mellitus in Turkey

Satman I. , Akalin S. , on behalf of Cost of Diabetes Study Group S.

Introduction: An update of health economics analysis of diabetes mellitus (DM) in Turkey was performed. The primary objective was to collect and calculate the healthcare resources utilized for the management of DM.Methods: Thirty-one out of 40 randomly chosen centers completed the study. Medical files were reviewed for the data recorded for at least two years prior to the study. Collected data included laboratory tests, treatments, inpatient/outpatient f...

ea0029p678 | Diabetes | ICEECE2012

Hyperhomocysteinemia as Risk’s Factor of Diabetic Nephropathy in the Patients with Diabetes Mellitus Type 1 and Depression

Navmenova Y. , Savasteyeva I. , Kapliyeva M. , Mokhort T.

The aim was to evaluate the space of hyperhomocysteinemia presence with depression and diabetic nephropathy (DN) in diabetic mellitus type 1 (DMT1) patients.Materials and methods: it was examined 147 patients with DMT1 (57.1% of males, 42.9% - females) and duration of disease was 11.17 [9.07;12.26] years. Moderate age was 40.08 [30.44; 48.79] years. DN of 3–5 stages was diagnosed in 43 patients (29.3%). To provide analysis it used blood serum creati...

ea0029p732 | Diabetes | ICEECE2012

Exenatide versus insulin glargine in type 2 diabetes inadequately treated with metformin

Karagianni P. , Polyzos S. , Kartali N. , Zografou I. , Sambanis C.

Introduction: The recent ADA and EASD algorithm for the treatment of type 2 DM suggests addition of basal insulin or GLP-1 agonist to pre-existing treatment when glycemic control is not achieved.Aim: Compare efficacy and safety of exenatide (E) versus insulin Glargine (G) added after metformin monotherapy.Patients and methodOur study was open labeled, non- randomized, retrospective and included 48 patients, 1...

ea0029p868 | Endocrine tumours and neoplasia | ICEECE2012

Medullary thyroid carcinoma with liver metastasis presenting as watery diarrhea for 1 year

Lam I. , Chaing H. , Wang C. , Chang C.

A 66-year-old woman had no history of systemic diseases. She had developed watery diarrhea for 4 months initially, without abdominal pain, fever, any aggravating or relieving factor. She visited gastroenterologist, and colonoscopy showed only mixed hemorrhoid. Irritable bowel syndrome was impressed then. Thus, anti-spasmodics and anti-diarrheals were prescribed. However, diarrhea persisted for 1 year, and body weight loss of 7 kg occurred during this period of time. She later ...

ea0029p869 | Endocrine tumours and neoplasia | ICEECE2012

Antiproliferative effect and control of catecholamine release with octreotide in a patient with giant bilateral pheochromocytoma

Katalinic D. , Plestina S. , Vrkljan M. , Aleric I. , Maric A.

Introduction: Pheochromocytomas are rare but treacherous catecholamine-producing tumors of the medulla of the adrenal glands (originating in the chromaffin cells), or extra-adrenal chromaffin tissue. We refer a case with stabilization of tumor growth and hormonal improvements following repeated s.c. injections of octreotide.Case report: We report a female patient aged 35 with a finding of bilateral adrenal mass with sever cardiovascular symptomatology (f...

ea0029p968 | Female Reproduction | ICEECE2012

Assessment of insulin resistance and carotid intima media thickness, cardiovascular risk factors in PCOS with normal OGTT

Yildir I. , Kutluturk F. , Tasliyurt T. , Yelken B.

The patients with polycystic ovary syndrome (PCOS) are at increased risk for insulin resistance, central obesity, dyslipidemia and hypertension. In our study, we aimed to detect whether women with PCOS who had normal OGTT results have had insulin resistance. Moreover we investigated the association of probable insulin resistance with cardiovascular risk indicators such as hs-CRP and carotid intima media thickness (CIMT).In total, 34 untreated PCOS patien...