Endocrine Abstracts

Over the last decades, studies using pharmacological approaches and transgenic mouse models have defined the major roles of bile acids as signaling molecules. Bile acids control many physiological functions such as lipid homeostasis, glucose, and energy metabolisms. In the last years, bile acids have been demonstrated to control male reproductive function. Here, we will highlight the impacts of bile acids on testicular physiology fo...

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Graves’ orbitopathy or thyroid eye disease (TED) represents the most common extra thyroidal manifestation of Graves’ disease. Smoking and radioactive iodine therapy are the most important modifiable risk factors. Thyrotropin receptor and insulin-like growth factor-1 receptor crosstalk, orbital inflammatory infiltration and activation of orbital fibroblasts lead to perpetuation of orbital inflammation a...

Thyroid hormone transporters at the plasma membrane govern intracellular thyroid hormone concentrations. MCT8 represents a key thyroid hormone transporter. MCT8 deficiency (also known as Allan-Herndon-Dudley syndrome) is a devastating developmental disorder caused by mutations in the MCT8 gene (located on the X-chromosome), with an estimated prevalence of 1:70.000 males. The phenotype comprises (1) a &#...

Osteoclasts are long lived highly specialised bone resorbing cells which form through the fusion of mononuclear pre-cursor cells and are believed to follow a linear fate and undergo apoptosis at the end of their life cycle. A number of anti-resorptive therapeutics target these cells, either preventing their resorptive function, Bisphosphonates, or inhibiting their formation, Denosumab (Anti-RANKL-Dmab). These agents have achieved success i...

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