Endocrine Abstracts

High level of triglycerides (TG) in plasma is a risk factor for cardiovascular disease. Various treatment strategies aimed at decreasing plasma TG concentrations affect synthesis of lipoproteins in the liver and/or increase clearance of TG by peripheral tissues. Lipid-lowering effects of fibrates reflects modulation of the liver metabolism. Antidiabetic agents thiazolidinediones (TZD) lower plasma TG by enhancing lipoprotein lipase activity in white adipose tissue (WAT). Long-...

Pituitary development is governed by activation of a cascade of transcription factors that orchestrate both pituitary morphogenesis and differentiation. Among them, loss of function of PROP1 is the most common genetic cause of combined pituitary hormone deficiency (CPHD) with two PROP1 gene variants (c.[301_302delAG];[301_302delAG] and c.[150delA];[150delA]) being most prevalent. We identified the homozygous c.[301_302delAG] variant in 70% out of 67 Lithuania...

The prevalence of endocrinologic diseases in Slovak Republic in 2015 was about 390 000 patients e.g. the prevalence was about 7.1%. The objective of this study was to find out the basic relevant characteristics of delivery of endocrinologic care based on data from General Insurance Company with covering cca 63% of all inhabitants.Methods: The combined analysis from the GIC data was used.Results: 246 195 patients, 212 977 women and ...

Introduction: In the last few years new imunomodulatory drugs are used for the treatment of metastatic melanoma. One of these drugs is ipilimumab, a monoclonal antibody that activates the immune system by targeting CTLA-4 protein receptor. This monoclonal antibody is very effective but there is a higher risk of endocrinopathies like an adverse effect of treatment, mostly hypophysitis and hypothyroidism.Case: We present a 68-year-old patient with metastat...

PCOS is a common disorder that is reported to affect 5–7% of women of reproductive age. Although there has been debate about the diagnostic criteria for PCOS, hyperandrogenemia/hyperandrogenism, not explained by other causes, is a hallmark of the disorder, and it is included as an essential element in all ‘consensus’ diagnostic schemes. Studies on cultures of human theca cells derived from normal and PCOS women have demonstrated that PCOS theca secretes greater ...

The advent of mice as the most common animal used for metabolic studies was caused by the possibility to perform gene manipulations in this species (which first very recently has become possible in the previously most studied animal: the rat). Although the mouse in many ways would seem just to be a smaller version of the rat, the smaller size indirectly has added a confounding factor to interpretation of metabolic studies. The reason is that the environmental temperatures unde...

Introduction: Growth is an important and sensitive indicator of child health. Abnormal growth is a common consequence of many conditions, therefore its identification acts as a useful warning of possible pathology. Effective growth monitoring requires precise linear growth measurements; however, measurements are often inaccurate and unreliable. Measurement error influences the interpretation of growth patterns resulting in failure to identify underlying pathology or apparent g...

Background: The national audit from the British Association of Endocrine Surgeons and the Scandinavian Quality Register of Thyroid and Parathyroid Surgery have reported that 7–17% of patients have hypocalcaemia in the first 6 weeks after thyroid surgery. This study is a snap-shot of management of peri-operative hypocalcaemia using routine Calcichew supplements.Methods: Retrospective review clinical and biochemical data on consecutive p...

Jan-Åke Gustafsson, Sweden, AbstractThis prestigious prize is intended for established workers in the field of basic or clinical neuroendocrinology, and is generously supported by Ipsen. This year's recipient is Professor Jan-Åke Gustafsson. The prize will be presented as part of the ECE 2009 opening ceremony where Professor Gustafsson will deliver his lecture. Professor Gustafsson will also d...

Glucocorticoids (GCs) exert a wide variety of functions throughout the human body, including mediation of the stress response, regulation of lipid and glucose metabolism, immunosuppressive and anti-inflammatory actions, vascular effects, increase of bone resorption, as well as effects on the development and function of numerous organs. The immuno-suppressive effects of GCs are routinely used in the treatment of chronic inflammatory or immune diseases (e.g. inflammatory bowel d...