Endocrine Abstracts

Introduction: Aggressive corticotropinomas are more invasive than other pituitary tumors. Recent reports have documented the efficacy of temozolomide alone or in combination with an anti-angiogenic agent –bevacizumab in invasive pituitary adenomas treatment.Objective: Presentation a case of 56-year-old woman initially diagnosed as Cushing’s disease and the analysis of treatment procedures with special concentration on temozolomide and bevacizum...

Introduction: Acromegaly is a rare endocrinopathy which shows characteristic phenotypic and metabolic features. Primarily patients in their forties or fifties suffer from this disorder but the main problem is late diagnosis, especially in men, even 10 years after the first symptoms. We present an unusual clinical course of acromegaly with no phenotypic features to stress the need to perform complete evaluation of endocrine function in hypogonadal patients.<p class="abstext...

Objective: The aim of the study was to examine characteristics and treatment patterns of Polish acromegalic patients.Methods: A retrospective database analysis was conducted. Adult acromegalic patients treated medically for ≥1 year including at least three injections of lanreotide AUTOGEL 120 were recruited in 36 centres between 29/10/2010 and 31/03/2012. Descriptive analysis was performed to describe demographic and clinical characteristics, treat...

Introduction: Thyroid disorders have significant impact on patients’ quality of life (QoL). ThyPRO is a thyroid-specific QoL questionnaire applicable to patients with benign thyroid disorders. There is substantial evidence for its clinical validity and reliability in patients with benign thyroid disorders. ThyPRO consists of 85 questions summarized in 13 scales, measuring aspects of QoL relevant to thyroid patients. Our aim was to develop a validated Polish version of thi...

Introduction: Acromegaly is a rare disorder caused by excessive growth hormone production. Common clinical manifestations are visual changes as well as serious systemic complications. In childhood and adolescence, excessive growth hormone production leads to abnormal tall stature. To date, only a few studies have been published focusing on analysing the growth of patients with acromegaly, in particular regarding the growth of their parents and siblings. A&#...

Introduction: Clinically inapparent adrenal masses (incidentalomas) are detected incidentally by imaging procedures in 0.5–4.5% of the general population. Diagnostic process identifies functional and potentially malignant tumors. Adrenocortical tumors might be the first manifestation of non-classic congenital adrenal hyperplasia (NC-CAH). P30L, V281L and P453S mutations of CYP21 gene are the most common mutations of NC-CAH. The aim of the study was to evaluate the relatio...

Introduction: Thyroid hemiagenesis (TH) is characterised by congenital absence of one thyroid lobe.Aim: To assess possible association between TH and concomitant alterations of other structures derived from pharyngeal apparatus, which might potentially impact calcium-phosphate balance.Materials and methods: Studied group: 20 patients with TH. Control group: 20 subjects with bilobed thyroid, matched for age and gender. Serum concent...

Introduction: Carbohydrate disorders in the form of glucose intolerance or overt diabetes are prevalent and well-documented in acromegalic patients.Aim: To assess the prevalence of carbohydrate disorders and the correlations between BMI, the duration of the disease, GH and IGF-1 concentrations depending on the stage of progression of glucose intolerance in our acromegalic patients.Methods: Acromegaly was diagnosed using standards e...

Aim: The aim of the study was to evaluate the patients’ age and goitre size in relation to the form of hyperthyroidism, as well as the relationship between patients’ age and goitre size and function.Material and methods: The subject group included 484 patients (420 females and 64 males) with hyperthyroidism. Graves’ disease (GD) was diagnosed in 171 subjects and toxic nodular goitre (TNG) was found in 313 subjects. FT3, fT4...

Aim: The aim of the study was to evaluate the relationship between TSHAb levels and thyroid function and size in patients with Graves’ disease and then to estimate the influence of TSHAb on the outcome of 131I therapy.Material and methods: Two hundred and one patients (168 females and 33 males, mean age 47.76 years, range 18–84) with Graves’ disease were enrolled. Before therapy, plasma fT3, fT4, TSH (DELFI...