Endocrine Abstracts

M Kawata, Kyoto Prefectural University of Medicine, Kyoto, Japan AbstractMitsuhiro Kawata is Professor of Anatomy and Neurobiology at Kyoto Prefectural University of Medicine. He received both an MD and a PhD from Kyoto Prefectural University of Medicine and has spent his scientific career at the Rockefeller University and University of Edinburgh. His research interests over time lie in the search for the mechanism of ...

A third of UK residents develop cancer, but the risk of being diagnosed under age 50 years is under 4%. The four most common cancers account for 54% of all cases: breast (16%), lung (13%), colorectal (13%) and prostate (12%). Five-year age standardised survival has increased substantially in recent decades for breast, prostate and colorectal cancer resulting in latest figures of 77, 65 and 48%, respectively. Cancer is increasingly becoming a curable or chronic disease. At the ...

The public tends to associate anabolic steroid abuse with elite athletes due to headline news in the newspapers, unaware that abuse also occurs in the local gyms. Regular users may be suspicious of some members of their local gym, or is it just envy? Studies have shown, however, that in some gyms over 50% of members may be taking steroids, and includes both men and women. Abusers tend to start taking steroids in their teens and some even as young as 12 years. Because many are ...

More children with cancer are being cured (overall survival is now ~80%) – but at what cost? Although very few new chemotherapeutic agents have been introduced into the treatment of childhood cancer in recent years, significant progress has been made in understanding the child’s response to treatment. Many patients are now ‘risk stratified’ – not only based on stage or subtype of disease, but also on response to initial therapy. This has allowed the id...

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A-M Colao, University Federico II of Naples, Naples, Italy. AbstractDr Annamaria Colao has been involved in clinical laboratory research since 1980 as a student in Medicine. At that time, she entered into the study group of hypothalamus-pituitary tumours and was mentored by Dr Gaetano Lombardi. Since that time, her publications and research have focused on pituitary tumours, especially prolactinomas and acromegaly. Bes...

Fibroblast growth factor 1 gene (FGF1) is located within the blood pressure quantitative trait locus on human chromosome 5 and encodes a multifunctional regulator of cardiovascular function and structure. To dissect associations between blood pressure and this positional candidate gene 51 FGF1 single nucleotide polymorphisms identified either in sequencing or/and public databases were genotyped in 629 individuals from 207 white hypertensive families. Linkage disequilibrium map...

PHP has four serious complications: urinary calcium stone disease; nephrocalcinosis; high-turnover metabolic bone disease; and hypercalcemia. Medical management is reserved for patients who are asymptomatic or who have failed, refused or are unfit for surgery. Aims of medical management are to prevent increase in severity of disease and to ameliorate and prevent the disease complications.Prevention of increase in severity includes regular follow-up, ensu...