Endocrine Abstracts

Background: Acute kidney injury (AKI) is common and serious, with no specific treatment. AKI may increase the risk of dysfunction in organs other than the kidney, further increasing the morbidity associated with AKI. The mechanisms of organ cross-talk after AKI are unclear. Small animal models have suggested that infiltration of inflammatory cytokines into extra-renal organs leads to cellular extravasation, oedema and further injury. In this study we used a large animal model ...

Objective: A review of the efficacy and safety of radioiodine treatment for Graves’ disease.Methodology: Patients were identified following a search of the nuclear medicine departmental database. Consecutive patients who had radioiodine in 3-year period from January 2009 to December 2011 were included in the audit. Information was obtained from medical notes, blood results and nuclear medicine database. Data was analysed using Microsoft Excel.<p...

Background: The majority of thyroid nodules are clinically insignificant, however considerable overlap in radiological characteristics exists for benign and malignant lesions. Recently, validated radiological criteria using thyroid imaging reporting and data system scoring (TIRADS) have shown correlation between cumulative suspicious features and risk of malignancy1.Objective: To assess sensitivity, specificity and reliability of ultrasound sc...

Aim: A cohort of adrenal incidentalomas which had radiological or histological characteristics in keeping with an adrenal adenoma was analysed in terms of the radiological and functional characteristics.Methods: A retrospective cross-sectional analysis of a cohort of adrenal adenomas was carried out. Lesions were followed up for a median of 8.2months (IQR 1.4–34.6). In the majority of patients (69.95%), the diagnosis of a benign adrenal adenoma was...

Aim: There are few reports discussing incidence and characteristics of the whole group of Cushing’s syndrome patients in the literature. The aim was to establish the incidence of endogenous Cushing’s syndrome with in-depth analysis of their various subtypes in a well-defined population.Methods: Retrospective cross-sectional analysis of Cushing’s syndrome patients diagnosed between 2008 and 2017. A thorough search for patients was carrie...

Vitamin D is a large group of structurally similar substances (calciferols) with diverse biological functions. Although approximately 40 different vitamin D metabolites have been determined so far, only 1,25-dihydroxyvitamin D was considered to be biologically active and the determination of 25-hydroxyvitamin D (25-OH D) served a tool to assess vitamin D supply. Recently it was found that also C3-epimers of vitamin D have their biological effect, however these effects differ f...

Several recent publications have advocated that patients with primary and secondary adrenal insufficiency (PAI and SAI) be given emergency injectable hydrocortisone to reduce the risk of adrenal crisis. There is a limited evidence-base for this recommendation and consequently the Edinburgh Centre for Endocrinology (ECE) does not routinely issue kits to its patients. This study assessed the frequency of hospital presentations in ECE’s AI patients, and the severity of their...

A 59-year-old gentleman presented to the Medical Admission Unit with facial and ankle oedema following a dog bite. He did not have any significant past medical history. Initially, he was treated for angioedema. His oedema worsened to anasarca, blood pressure rose and was found to be hypokalaemic. Echocardiogram showed a normal left ventricular ejection fraction. Urine protein creatinine ratio was <0.5 g/24 h. Vasculitic and autoimmune screen were negative. Eight weeks late...

Introduction: Guidance on the management of diabetic ketoacidosis (DKA) has recently been updated in an effort to reduce the risk of complications, in particular, cerebral oedema. However, differences in recommendations for children and adults persist making the care of teenagers with DKA confusing and potentially hazardous.Aims: To compare the management of DKA in teenage patients in paediatric and adult care settings in the context of the latest nation...

Although pituitary abnormalities are the most commonly reported endocrine feature in septo-optic dysplasia, other endocrine abnormalities have not been described so far. We present a case of septo-optic dysplasia (SOD) and pituitary dysfunction, complicated by X-linked adrenoleucodystrophy (X-ALD) and primary adrenal insufficiency.A 4-year-old boy was referred with hypoglycaemic episodes and seizures during intercurrent illnesses. He had a history of pol...