Endocrine Abstracts

The link between thyroid hormone deficiency and optimal neurodevelopment in early childhood is well established. More recently, data from animal model experiments and epidemiological databases have indicated that perturbations in maternal and fetal thyroid hormone concentrations may affect fetal outcome and, in particular, have an adverse effect on neurodevelopmental outcome. Epidemiological evidence in human pregnancies has indicated that hypothyroxinaemia in the fetus in the...

Recent advances in immunology have resulted in the development of new classes of immune-modulatory therapy in the management of cancers and an increased overall survival for various cancers. Immune checkpoint direct antibodies block intrinsic down-regulators of immunity, such as cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) or its ligand, programmed cell death ligand 1 (PD-L1). As an inevitable consequence of increasing the activity of the immune...

As information scales in non clinical environments, people are faced with challenges as to what information is relevant to healthcare teams. PeopleWith is a digital health company developing solutions to help people engage with their health. Patients who engage with their health get better treatment outcomes. How do we support patients on this journey to become fully activated in their health and become a participant in conversations to optimise outcomes....

Information is becoming increasingly available in non clinical environments with the scale in functionality in smart mobile devices, wearables and home health devices. This creates a challenge for patients and Clinicians as to what information to capture and how to present and share it. PeopleWith has been developed by a healthcare veteran with 30 years experience working in Nursing and the Pharmaceutical industry. This information is known as Patient generated health data and...

Information is becoming increasingly available in non clinical environments with the scale in functionality in smart mobile devices, wearables and home health devices. This creates a challenge for patients and Clinicians as to what information to capture and how to present and share it. PeopleWith has been developed by a healthcare veteran with 30 years experience working in Nursing and the Pharmaceutical industry. This information is known as Patient generated health data and...

Water balance disorders following neurosurgery are well recognised and may give rise to both hypo- and hypernatraemia. We present the case of a 42-year-old male who developed a triphasic response after extended transsphenoidal surgery for a pituitary stalk lesion. The patient presented with a 4 month history of unremitting frontal headaches and dizziness. MRI confirmed a 15×15 mm stalk lesion. Clinical examination including formal visual perimetry was unremarkable. Blood ...

Background: HSD-1 converts cortisone to cortisol in tissues in which cortisol excess is associated with morbidity including liver, adipose, bone, and brain. SPI-62 is a potent HSD-1 inhibitor in clinical development for treatment of Cushing’s syndrome and autonomous cortisol secretion, and as adjunctive therapy to prednisolone in polymyalgia rheumatica. In Phase 1 clinical trials SPI-62 was generally well tolerated and associated with maximal liver and brain HSD-1 inhibit...

Determining the sequence of events controlling preadipocyte commitment and subsequent terminal differentiation into adipocytes is critical to gain insight into brown and white fat physiology and metabolic dysfunction. MicroRNAs (miRNAs) are important regulators of gene expression and emerging evidence supports their involvement in adipogenesis and adipose metabolism. The aim of this study is to 1) identify miRNAs that modulate differentiation or function of white and brown adi...

A 49 year old male, known to suffer from hypertension, was bein investigated for recurrent occipital headaches. An MR Brain showed a 2.4 cm×2.8 cm×4.2 cm sellar mass with suprasellar extension, optic chiasm compression, infrasellar extension with erosion into the sphenoidal sinus, lateral extension into the left sided cavernous sinus and further extension through the cavernous sinus into the parietal lobe. The tumour contained some cystic areas and moderately enhance...

Background: Advances in technology have led to new approaches in diabetes management. CGM has been associated with improvements in HbA1c, however, the evidence is limited and there are substantial cost considerations. The main aim of this audit was to assess the impact of CGM and FGS on HbA1c levels.Method: A retrospective analysis of the use of CGM and FGS in paediatric patients under the care of the children’s diabetes team at James Cook Hospital,...