Endocrine Abstracts

In July 2010, a 69-year-old woman presented because of a CT proven 5th lumbar vertebral metastasis of thyroid carcinoma and in August she underwent a total thyroidectomy and central node dissection. Histopathology revealed a moderately differentiated Hürthle cell carcinoma which was according to TNM classification pT3N1M1 tumor. Thereafter, a right hemylaminectomy of L5 and metastasectomy was performed in order to decompress the L5 and S1 spinal nerves. The histopathology...

We describe four cases of Thiamine Responsive Megaloblastic Anaemia (TRMA), Rogers Syndrome. Three cases are siblings, the fourth from another family. They are all of Pakistani origin and born to consanguineous parents. All have the clinical triad of megaloblastic anaemia, non-type 1 diabetes mellitus, and sensorineural deafness.The SLC19A2 gene mutation affects the transport of thiamine, which is required for normal tissue growth and development in huma...

We recently identified a group of neurons in the arcuate nucleus of the mammalian hypothalamus that co-localize three neuropeptides, kisspeptin, neurokinin B and dynorphin, each of which has been shown to play a critical role in the central control of reproduction. Growing evidence suggests that this subpopulation, abbreviated as the ‘KNDy’ subpopulation, plays a key role in mediating hormonal feedback control of GnRH secretion. KNDy cells are a major target for ster...

A 37-year-old Caucasian man was referred for assessment of borderline hypocalcaemia (2.15 mmol/l) associated with hypophosphataemia (0.32 mmol/l) and elevated serum PTH (145 ng/l). Serum 25OH cholecalciferol was normal (39 mmol/l). Some weeks earlier he had been admitted to hospital as an emergency with severe, colicky right sided abdominal pain. The pain had settled spontaneously and no cause was found. He had subsequently suffered isolated attacks of strangury, dysuria and t...

Background: The UK has advocated a policy of screening children’s growth opportunistically. Such a policy has merit if measurements are performed and the data easily retrieved to enable a possible referral for specialist assessment.Height measuredWeight measured N...

Primary Carcinoid tumour of Epididymis is a very rare presentation. It accounts to only 0.23% of Carcinoid tumours. Here we present a patient with Primary Carcinoid tumour of Epididymis, which was successfully resected.A 57 year old gentleman with no significant past medical history was seen with painless swelling of his Right testes. He had no symptoms such as weight loss, Diarrhoea or flushing on direct questioning. Examination revealed a Solid, non-te...

Introduction: Weight gain and obesity promote metabolic syndrome, diabetes and other cardiovascular risk factors. Weight loss achieved by lifestyle change can limit progression of cardiovascular risk factors. What is the current approach to obesity in general practice and can a nurse- led programme result in clinically beneficial weight change?Methods: The Counterweight Programme has developed a model of best practice for obesity management in UK primary...

Anorexia nervosa (AN) is a psychiatric disorder featuring multiple endocrine abnormalities, comprising a decrease in IGF-I production and an increase in GH concentrations. This resistance to GH action may contribute to impaired haematopoiesis in AN as GH/IGF-I modulate blood cell proliferation and GH therapy exerts beneficial effects on hematocrit values in GH deficient patients. Aim of the present study is to evaluate the link between GH/IGF-I status and haematologic p...

We report the cases of two identical twins with Graves’ disease which proved very difficult to control and followed very similar stormy course. Twin A was a 20 years old female of 12 weeks gestation when she was referred to endocrine clinic with history of weight loss, palpitations and tremor. Her thyroid function tests revealed TSH <0.08 mU/L (0.03–4.30), FT4 82.5 pmol/L (12–22 pmol/L) and FT3 44.4 pmol/L (2.8–7.1) with positive thyroid receptor ant...

We report the case of a 27 year old female who was referred to our diabetes team from the antenatal clinic, when she was found to have an abnormal glucose tolerance at 16 weeks of gestation (fasting and 2 hours blood glucose values of 5.1 mmol/L and 12.2 mmol/L respectively). At the same time she was suffering with severe hyperemesis gravidarum for many weeks and had suffered significant weight loss (thyroid function tests were unremarkable). She had no specific symptoms to su...