Searchable abstracts of presentations at key conferences in endocrinology

ea0032p228 | Clinical case reports – Pituitary/Adrenal | ECE2013

Xanthomatous hypophysitis as a cause of cluster headache: a case report

Csajbok Eva , Magony Sandor , Sepp Kirsztian , Valkusz Zsuzsanna , Barzo Pal , Tiszlavicz Laszlo

Introduction: Hypophysitis is an inflammatory disease of the pituitary gland that may mimic pituitary tumors clinically and radiologically. Primary hypophysitis has traditionnaly been classified as lymphocytic (LH), granulomatous (GH), and xanthomatous (XH).Case description: We report on a case of a xanthomatous hypophysitis initially diagnosed as pituitary adenoma. A 23-year-old men suffered from typical cluster type headache. Two years after the first ...

ea0021p275 | Pituitary | SFEBES2009

Recurrence rates in patients with non-functioning pituitary adenomas presenting with acute apoplexy: a long-term follow-up study

Pal Aparna , Karavitaki Niki , Capatina Christina , Tenreiro Alma , Guardiola Patricia , Wass John

Background: Pituitary apoplexy has been reported in around 2% of surgically treated adenomas. Around 45% of all pituitary tumours presenting with apoplexy are non-functioning ones (NFAs). Currently, no data exist on recurrence rates in patients with NFAs who have had classical apoplexy.Aim: We therefore, put together our data aiming to provide the first reliable series on recurrence rates in patients with NFA and classical pituitary apoplexy.<p class...

ea0092ps1-10-02 | Basic Thyroid Gland, Iodine &amp; Autoimmunity Basic | ETA2023

Decreasing iodine intake among pregnant faroese women

Sofia Veyhe Anna , Johannesen Herborg , Hansen Solrunn , Petursdottir Johanna , Weihe Pal , Strom Marin , Andersen Stig

Introduction: Iodine is essential for thyroid funciton and severe deficiency adversely affects the developing brain. A raised and sufficient intake is particularly important during the pregnancy. Iodine sources include sea foods and sea salt, and it is available as a dietary supplement. The former was previously important to the Faroses diet but the intake of traditional Faroses foods is decreasing with at likely parallel influence on the iodine intake. Currently, there is no ...

ea0093oc22 | Oral communication 4: Pituitary and Neuroendocrinology | EYES2023

Comparative evaluation of diagnostic performance of the most commonly used screening tests for pathological hypercortisolism: A single centre analysis

Efthymiadis Agathoklis , Loo Helen , Shine Brian , Tomlinson Jeremy , Pal Aparna , Pofi Riccardo

Background: To date, there is no consensus as to the gold-standard screening test for diagnosing Cushing’s Syndrome (CS).Objectives: This study aimed to: a) compare the ability of late-night salivary cortisol (LNSC) against overnight dexamethasone suppression test (ONDT) and urinary free cortisol (UFC) as screening test for pathological hypercortisolism (PH); b) test the performance of those tests in diagnosing Cushing’s disease (CD) or mild au...

ea0094p321 | Adrenal and Cardiovascular | SFEBES2023

The dexamethasone assay as a useful tool to identify false positive dexamethasone screening test results

Humayun Khan Huma , Loo Helen , Pofi Riccardo , May Christine , Jafar-Mohammadi Bahram , Shine Brian , Pal Aparna

The dexamethasone suppression test (DST) is a common screening test in Cushing’s syndrome but associated with false positive result in 10-20%. One cause of false positivity is inadequate dexamethasone absorption. An assay to measure serum dexamethasone concentration can be used to validate the accuracy of the DST result.Aims: To audit 1) Use of the dexamethasone assay in DSTs 2) How frequently dexamethasone levels are inadequate 3) ...

ea0077op2.2 | Adrenal and Cardiovascular | SFEBES2021

Single-centre analysis of 900 short synacthen tests: do pre-test clinical or biochemical variables predict failure?

Dilrukshi M D S A , Beck K J , Loo H , May C , Jafar-Mohammadi B , Pofi R , Tomlinson J W , Pal A

Short synacthen test (SST) is the most widely used dynamic test of hypothalamic-pituitary-adrenal (HPA) axis function. It’s simple to conduct but requires nursing time and is relatively costly given 15-fold price increase in synacthen since 2015. We audited our SST use with the aim of reviewing clinical indications for testing and identifying useful predictors of test outcome. Baseline referral, clinical and biochemical data were retrospectively collected for individuals ...

ea0077p81 | Neuroendocrinology and Pituitary | SFEBES2021

Is gigantism different from acromegaly in terms of causes of death, comorbidities and treatment? A preliminary retrospective study of 156 UK giants

Kaniuka-Jakubowska Sonia , Abeyaratne Dayakshi , Pal Aparna , Plummer Zoe , Archer Natasha , Ayuk John , Kaszubowski Mariusz , Wass John , Korbonits Marta

Introduction: Although acromegaly and pituitary gigantism have the same pathological cause, they have different disease characteristics.Aim: To study tumour size, treatment course and the most common comorbidities in a population with young-onset acromegaly.Materials and Methods: UK Acromegaly Register (UKAR, 22 centres, 1997-2017) retrospective analysis, enriched with patients from the FIPA-consortium. We defined gigantism as diag...

ea0077p210 | Neuroendocrinology and Pituitary | SFEBES2021

Management of cranial Diabetes Insipidus in a tertiary centre – clinical outcomes and patient perception of care

Dilrukshi MDSA , Vickars Marcus , May Christine , Makaya Taffy , Ryan Fiona , Mohammadi Bahram Jafar , Wass John , Pal Aparna , Garrahy Aoife

There is growing recognition within Endocrinology physician and patient groups of morbidity and mortality in association with prescribing errors and dysnatraemia, in hospitalised patients with cranial diabetes insipidus (CDI). The aims of this study were firstly, to assess outcomes in hospitalised patients with CDI by review of electronic records from 2012-2021, and secondly, to assess the same patient cohort’s perceptions of their care via telephone questionnaire. 109 pa...

ea0081p416 | Pituitary and Neuroendocrinology | ECE2022

Cabergoline monotherapy in acromegaly – a multicenter, retrospective, cohort study of non-irradiated patients using current criteria for disease control

A Urwyler Sandrine , Samperi Irene , Lithgow Kirstie , Mavilakandy Akash , Matheou Mike , Ayuk John , Bradley Karin , Pal Aparna , Reddy Narendra , Karavitaki Niki

Background: Dopamine agonists (DA) are included in the management algorithm of acromegaly. Studies on cabergoline monotherapy report IGF-1 normalisation in between 0% and 100% of the patients during treatment periods ranging between 2.6 and 24 months. However, in many of these studies, previous radiotherapy is a confounding factor. Furthermore, real world data applying the current disease control criteria (normal IGF-1 and GH<1 mg/l) are not available. The aim of this stud...

ea0086p301 | Adrenal and Cardiovascular | SFEBES2022

Feasibility of primary aldosteronism screening in primary care – prevalence and concordance with secondary care assessment

Marie Hannon Anne , Dissanayake Harsha , Warner Bronwen , Mihai Radu , James Tim , Ray David , Shine Brian , Pal Aparna

Background: Primary aldosteronism (PA) is the commonest cause of secondary hypertension. Reported prevalence is about 30% in hypertensive population. Success of screening for PA in general practice (GP) is unknown. Expected challenges include laboratory access, transport issues and interfering medications.Aims: We aimed to report prevalence of PA in a large primary care cohort, the correlation between GP and in-hospital ARR and to assess if a change in r...