Searchable abstracts of presentations at key conferences in endocrinology

ea0065p11 | Adrenal and Cardiovascular | SFEBES2019

Cosyntropin stimulation test post unilateral adrenalectomy for non-steroid secreting lesions: not all who fail require steroids

Zaman Shamaila , Almazrouei Raya , DiMarco Aimee , Palazzo Fausto , Wernig Florian

Aim: Recent studies reported a wide range in baseline and peak cortisol responses to surgery. We report the results of cosyntropin stimulation testing following unilateral adrenalectomy for non-steroid secreting lesions.Methods: Data of 36 patients who underwent cosyntropin stimulation testing on the second day post unilateral adrenalectomy were collected retrospectively. None of the patients had clinical signs of hypercortisolism. No patient received pr...

ea0065p95 | Bone and calcium | SFEBES2019

A case of successful parathyroidectomy in the third trimester of pregnancy

Sanderson Miriam , Kostoula Melina , Palazzo Fausto , Boret Tony , Kong Chantal

Primary Hyperparathyroidism (pHPT) affects approximately 1:2000 women under 40 years of age, so pHPT in pregnancy is uncommon. It is associated with significantly increased risks of morbidity for mother and foetus. Conventionally, surgery is recommended, ideally early in the second trimester. A 31-year-old woman attended the Accident and Emergency department at 26+4 weeks of her third gestation, with severe loin pain and fever. She had a past medical history of pyelonephritis....

ea0049ep123 | Clinical case reports - Pituitary/Adrenal | ECE2017

The difficulty in predicting aggressive tumour behaviour of phaeochromocytomas

Mills Edouard , Naqvi Ali , Dina Roberto , Palazzo Fausto , Wernig Florian

Phaeochromocytoma and paragangliomas (PH/PG) are rare neuroendocrine tumours. Prediction of aggressive tumour behaviour remains a major challenge. The Phaeochromocytoma of the Adrenal gland Scaled Score (PASS) is used to separate benign from malignant lesions with a score > 4 showing potential for biologically aggressive behaviour. Pre-operatively, MIBG together with CT/MRI remain the diagnostic radiological gold standard.We report a 68-year-old fema...

ea0048cp18 | Poster Presentations | SFEEU2017

An elusive parathyroid gland

Plichta Piotr , Randall Joanne , Di Marco Aimee , Palazzo Fausto

We describe a case of a male who presented to a rheumatologist with hypercalceamia at the age of 22 in 1995. Investigations were incomplete and he was lost to follow up. He was referred to a general surgeon in 2002 as another blood test had showed hypercalcaemia of 2.8 mmol/l (2.2–2.6), parathyroid hormone 9.5 pmol/l (1.6–6.9). A spot urine calcium/creatinine excretion ratio was 0.014. It was felt he probably had primary hyperparathyroidism and he was managed conserv...

ea0031p69 | Clinical practice/governance and case reports | SFEBES2013

Management of primary hyperparathyroidism during pregnancy: a case series of the lessons learnt

McCullough Katherine , Martin Niamh , Palazzo Fausto , Williamson Catherine , Meeran Karim

Primary hyperparathyroidism (PHPT) is a common condition, affecting approximately 1% of the general population. In women of childbearing age, the correct diagnosis and management is particularly important since PHPT is associated with miscarriage, pre-eclampsia, intrauterine growth restriction, preterm delivery and postpartum neonatal hypocalcaemia. We describe a case series of six women diagnosed with PHPT and their management during pregnancy. In four cases, the PH...

ea0031p92 | Clinical practice/governance and case reports | SFEBES2013

Life threatening airway obstruction secondary to a large probable parathyroid cyst

McCullough Katherine , Constantinidis Vasilis , Badman Michael , Jackson James , Palazzo Fausto

Parathyroid cysts are rare, usually asymptomatic and typically present as a neck lump. They are most commonly detected in middle-aged women and can occasionally present with compressive symptoms. True parathyroid cysts are non-functional and benign in nature, allowing a more conservative approach to their management in many patients. We present the case of an 82-year-old lady with a past medical history of a presumed parathyroid cyst which was drained by the ENT surgeons. Thre...

ea0025p203 | Endocrine tumours and neoplasia | SFEBES2011

Five year experience of investigation and management of histologically proven chromaffin cell tumours

Amin Anjali , Palazzo Fausto , Meeran Karim , Todd Jeannie

Background: Chromaffin cell tumours are rare but potentially curable endocrine tumours. These tumours may be sporadic or familial in nature. Biochemical tests are normally performed initially, followed by radiological investigation.Aim: To assess the correlation of biochemical and radiological investigations with histologically proven chromaffin-cell tumours in patients with sporadic and familial disease.Methods: We retrospectively...

ea0021p81 | Clinical practice/governance and case reports | SFEBES2009

Hypertension in familial adenomatous polyposis (FAP): don't be conn'd!

Hopkins Tom , Tan Tricia , Salem Victoria , Palazzo Fausto , Meeran Kareem

A 36-year-old man, presenting to his GP with severe intermittent headaches, was found to have a blood pressure of 210/110 mmHg. He had been diagnosed with familial adenomatous polyposis (FAP) in early childhood, and had had a total colectomy with ileo-rectal anastamosis at the age of 17. Routine surveillance CT imaging the following month revealed an incidental finding of bilateral adrenal masses (right 4×2 cm, left 2.7×2.9 cm).On assessment in...

ea0021p117 | Clinical practice/governance and case reports | SFEBES2009

The use of the urine calcium/creatinine clearance ratio in patients with hypercalcaemia

Mahmud Mohammad , Jayasena Channa , Palazzo Fausto , Meeran Karim , Dhillo Waljit

Background: Hypercalcaemia is defined as an elevated serum calcium level above 2.6 mmol/l and occurs in 1 in 1000 of the population. It commonly results from primary hyperparathyroidism (PHP) which is usually treated with parathyroidectomy. A less common cause of hypercalcaemia is familial hypocalciuric hypercalcaemia (FHH) which is caused by mutations inactivating the calcium-sensing receptor; however FHH is relatively benign and requires no treatment. It is clearly important...

ea0021p189 | Endocrine tumours and neoplasia | SFEBES2009

Laparoscopic versus open adrenalectomy and adjuvant mitotane in adrenocortical carcinoma

Ali Sarah , Qureshi Asjid , Clarke Ian , Palazzo Fausto

Introduction: Adrenocortical carcinoma (ACC) is an uncommon aggressive malignancy. Despite surgical resection, recurrence rates are high. Two areas of contention currently involve treatment of ACC: the role of laparoscopic surgery in removal of large, potentially malignant tumours and the role of Mitotane. We present a case of a large adrenal tumour, later confirmed as ACC, where initially laparoscopic adrenalectomy was considered, and adjuvant Mitotane has been given despite ...