Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep71 | Adrenal cortex | ECE2015

Fludrocortisone therapy in patients with primary adrenal insufficiency: relationships with different hydrocortisone doses

Ekman Bertil , Quinkler Marcus , Jones Beverly A , Marelli Claudio , Murray Robert , Zelissen Pierre , Wahlberg Jeanette

Introduction: During recent years many authors have advocated lower hydrocortisone doses in patients with primary adrenal insufficiency (PAI) mainly due to worries for non-physiological effects like increased cardiovascular risk and bone resorption, but very little attention has been drawn to fludrocortisone dosing. Our main hypothesis was that that the higher hydrocortisone dose, the lower the fludrocortisone dose and vice versa.Design: The Eur...

ea0035p43 | Adrenal cortex | ECE2014

Detection of high rate of intercurrent illnesses and adrenal crisis in patients with adrenal insufficiency by using a patient's diary

Quinkler Marcus , Ekman Bertil , Fitts David , Marelli Claudio , Murray Robert , Zelissen Pierre

Introduction: Current understanding about the frequency of adrenal crisis in patients with adrenal insufficiency (AI) relies exclusively on retrospective data (~6.3 adrenal crisis per 100 patient-years). In addition, no data are available about the frequency of intercurrent illness events in AI patients. For the first time we prospectively used a patientÂ’s diary in recording events of adrenal crisis and intercurrent illness in AI patients.Design: Th...

ea0035p55 | Adrenal cortex | ECE2014

Effects of adrenal insufficiency on body composition and metabolic indices: data from the European Adrenal Insufficiency Registry (EU-AIR)

Murray Robert , Ekman Bertil , Fitts David , Marelli Claudio , Quinkler Marcus , Zelissen Pierre

Introduction: Data concerning patients with adrenal insufficiency (AI) have been limited by small numbers of patients reflecting the relatively low prevalence of this disease. The European Adrenal Insufficiency Registry (EU-AIR) is a multicenter observational study of patients with both primary and secondary AI. Enrollment commenced August 2012. Comprehensive demographic data, aetiology of AI, and details of glucocorticoid replacement therapy are collected at baseline. Safety ...

ea0070aep21 | Adrenal and Cardiovascular Endocrinology | ECE2020

Psychosocial determinants of body acceptance and quality of life in women with congenital adrenal hyperplasia

Tschaidse Lea , Quinkler Marcus , Nordenström Anna , Van Der Grinten Hedi Claahsene , Reisch Nicole

Background: Women with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency have a poor Quality of Life (QoL) compared to the general population and are less satisfied with their body appearance. Data indicates that psychosocial determinants such as good professional and general support could be associated with an improved QoL. Since there is only little data available that has been deduced from samples of small size this effect should be further examined....

ea0032p49 | Adrenal cortex | ECE2013

European Adrenal Insufficiency Registry: a comparative observational study of glucocorticoid replacement therapy

Eckman Bertil , Fitts David , Marelli Claudio , Murray Robert , Quinkler Marcus , Zelissen Pierre

Introduction: A once-daily modified-release formulation of hydrocortisone (Plenadren®) has been developed to better mimic physiological cortisol secretion in the treatment of patients with adrenal insufficiency (AI). Here, we describe EU-AIR, an ongoing post-authorization observational study (registry) designed to collect information on AI management and to assess the long-term safety of Plenadren® compared with traditional glucocorticoid replac...

ea0026oc1.5 | Thyroid/Adrenal | ECE2011

Adrenal crisis and general morbidity in chronic adrenal insufficiency prospectively assessed in 472 patients

Hahner Stefanie , Spinnler Christina , Beuschlein Felix , Fassnacht Martin , Lang Katharina , Quinkler Marcus , Allolio Bruno

Adrenal crisis (AC) is a life threatening condition in chronic adrenal insufficiency (AI). Furthermore, recent data demonstrate increased mortality in this patient group.Incidence and causes of adrenal crisis as well as general morbidity and hospitalization was assessed in 472 patients in a prospective trial. Patients were contacted via mail every 6 months and in case of AC additionally by phone to evaluate the exact circumstances of AC. Criteria for AC ...

ea0026p29 | Adrenal cortex | ECE2011

TP53 and adrenocortical cancer: analysis of germline mutations and polymorphic changes in 140 patients

Herrmann Leonie , Heinze Britta , Fassnacht Martin , Willenberg Holger , Quinkler Marcus , Reisch Nicole , Allolio Bruno , Hahner Stefanie

Adrenocortical carcinoma (ACC) is part of the Li-Fraumeni tumour syndrome which is due to germline mutations in TP53. Recent studies demonstrate low penetrance mutations leading to later tumour manifestation. Furthermore, in ACC mutations outside the hotspot region have been found. TP53-polymorphisms have also been described to impact on p53 function. We, therefore investigated TP53 sequence alterations in a large cohort of adult patients with ACC.Method...

ea0020p20 | Adrenal | ECE2009

Chemokine receptor expression in the adrenal cortex and in adrenocortical tumours

Lang Katharina , Sturmer Andrea , Adam Patrick , Fassnacht Martin , Quinkler Marcus , Morcos Michael , Allolio Bruno , Hahner Stefanie

Introduction: Chemokines and their receptors (CR) have been demonstrated to be involved in tumour growth and site specific metastasis. Furthermore, several cytokines have been described to modulate adrenocortical function. Therefore, we have investigated the expression pattern and functional activity of chemokine receptors and of corresponding chemokines in adrenocortical tissue.Methods: Chemokine and CR expression was assessed by RT-PCR in normal adrena...

ea0016p7 | Adrenal | ECE2008

Health related quality of life differs between three replacement therapies in adrenal insufficiency

Bleicken Benjamin , Hahner Stefanie , Loeffler Melanie , Ventz Manfred , Allolio Bruno , Quinkler Marcus

Objective: There is evidence that current replacement regimens fail to restore well-being in patients with adrenal insufficiency (AI). No data is available on the effect of different therapeutical regimes (hydrocortisone, prednisolone, cortisone acetate) on the quality of life in these patients.Methods: About 883 patients with adrenal insufficiency were contacted, 526 patients participated (60%) and received a disease specific questionnaire and three sta...

ea0016p8 | Adrenal | ECE2008

Differences in quality of life between twice and thrice daily application of hydrocortisone in adrenal insufficiency

Bleicken Benjamin , Hahner Stefanie , Loeffler Melanie , Ventz Manfred , Allolio Bruno , Quinkler Marcus

Objective: There is evidence that current replacement regimens fail to restore well-being in patients with adrenal insufficiency. No data is available on the effect of twice or thrice daily administration of hydrocortisone on the quality of life in these patients.Methods: About 883 patients with adrenal insufficiency were contacted, 526 patients participated (60%) and received a disease specific questionnaire and three standardized questionnaires (SF36, ...