Searchable abstracts of presentations at key conferences in endocrinology

ea0014eje1 | European Journal of Endocrinology Prize Lecture | ECE2007

Cortisol and cardiovascular disease

Walker Brian R

Similarities between the metabolic syndrome and Cushing’s syndrome, and reversibility of the features of Cushing’s syndrome, suggest that cortisol may contribute to pathophysiology in both conditions and that reducing cortisol action may provide a novel therapeutic approach in metabolic syndrome. There is substantial evidence that circulating cortisol concentrations are higher in people with hypertension and glucose intolerance. The basis for t...

ea0014s15.4 | Novel bone hormones and regulators | ECE2007

Thyroid hormones/TR and bone

R Williams Graham

Childhood hypothyroidism results in severely delayed skeletal development whereas adult thyrotoxicosis is associated with a 3–4 fold increase in osteoporotic fracture. To investigate molecular mechanisms underlying these abnormalities we characterized the skeletal phenotypes of mice harboring dominant negative mutations (TRα1PV/+, TRα1R384C/+, TRβPV/PV) or deletions (TRα0/0, TRβ−/−) of the genes encoding TRα and TRβ. Endochon...

ea0012s34 | Adipocyte tissue and insulin resistance | SFE2006

The ins and outs of steroid hormones in human adipose tissue

Walker BR , Andrew R

Several enzymes are expressed in adipose tissue which catalyse interconversion of steroids, generating oestrogens (aromatase), androgens (5α-reductase 1), and glucocorticoids (11β-HSD1). These steroids may activate local receptors which influence body fat accumulation and distribution, or be secreted to exert endocrine effects. Several mouse models (e.g. aromatase and 11β-HSD1 knockout mice and studies with 11β-HSD1 inhibitors) illustrate the potential impo...

ea0012oc16 | Placenta, bone and genetics | SFE2006

Symptomatic improvement after parathyroidectomy for primary hyperparathyroidism

Mihai R , Sadler GP

IntroductionThere is growing interest in the impact of parathyroidectomy on quality of life in patients with primary hyperparathyroidism (PHPT). The aim of this study was to asses the symptomatic improvement in a cohort of patients with PHPT operated in a single centre in the UK.MethodsA prospective study of consecutive unselected patients with biochemical diagnosis of PHPT was approved by the Local Ethical C...

ea0012p26 | Clinical case reports/Governance | SFE2006

Unusual causes of hypercalcaemia in a DGH

Debono M , Banerjee R

ObjectiveTo describe a few cases of patients presenting with various unusual causes of hypercalcaemia to a District General Hospital.MethodsThree case histories, including detailed results of laboratory tests, are presented, and the findings are discussed.ResultsIn the first case we describe an eighty year old patient recently started on lithium carbonate for mani...

ea0012p28 | Clinical case reports/Governance | SFE2006

Abdominal pain……don’t miss the endocrine case!!

Debono M , Banerjee R

ObjectiveTo describe two cases of patients presenting with abdominal pain to the gastroenterologists. These were diagnosed with primary hyperparathyroidism and adrenal insufficiency respectively.MethodsTwo case histories, including detailed results of laboratory tests, are presented, and the findings are discussed.ResultsWe present a 62 year old gentleman who was ...

ea0011s41 | Stromal cell-matrix interactions | ECE2006

Wnt signalling in the stem cell niche

Clarke Alan R

It is well recognised that the intestinal epithelium has a remarkable capacity to regenerate after high levels of DNA damage or injury. Although the kinetics of this ‘clonogenic repopulation’ whereby a new stem cell repopulates the crypt is understood, little is known about the molecular mechanism underlying this, although upregulation of Musashi-1 is known to mark the process. By conditionally deleting genes that are lethal to the intestinal stem cells we have mimic...

ea0011p35 | Bone | ECE2006

Assessment of bone health and body composition in Glasgow school children

Rashid R , Ahmed SF

Objective: To examine different methods of analysing bone health and body composition in children and examine the relationships between these methods.Method: In a LREC approved cross-sectional study, DXA was used to assess bone mineral content (BMC) (at total body (TB), lumbar spine (LS), femur (F) and femoral neck (FN)), cross-sectional moment of inertia (CSMI) at the proximal femur and body composition (defined as Lean mass (LM) and Fat mass (FM)) in 6...

ea0011p195 | Clinical practise and governance | ECE2006

Long-term outcome in men with microprolactinoma

Rea R , Jeffcoate W

Introduction: It is accepted that hyperprolactinaemia associated with microprolactinoma may prove self-limiting in 25–30% women, and there is some suggestion from series of mixed gender that the same may be true in men.Methods: We have therefore reviewed the outcome in all men with microprolactinomas managed at the Department of Diabetes and Endocrinology, City Hospital, Nottingham, between 1994 and 2002. All had sustained and previously untreated h...

ea0011p217 | Comparative endocrinology | ECE2006

Ontogeny of galanin and vasotocin immunoreactivity in the supraoptic nucleus (SON) and the bed nucleus of the stria terminalis (BSTM) in chickens

Klein S , Grossmann R

Vasotocin (AVT), the avian homolog of vasopressin, is synthesized in the BSTM of chickens in addition to the hypothalamo hypophysial axis. In previous reports, sex specific AVT–immunoreactivity(ir) in male BSTM (Jurkevich et al. 1999) and it’s ontogeny were demonstrated (Grossmann et al. 2002). In addition, galanin (Gal) was found in male BSTM co-localized to AVT. In the present study, the ontogeny of AVT- and Gal-ir was investigated in the SON as part ...