Searchable abstracts of presentations at key conferences in endocrinology

ea0005p106 | Diabetes, Metabolism and Cardiovascular | BES2003

Metformin. Its effect on weight loss in obese patients with or without polycystic ovary syndrome

Mukhtar R , Pettit A , Robinson A

IntroductionMetformin is being increasingly used in the treatment of Polycystic Ovary Syndrome where it improves the metabolic and reproductive parameters through the improvement of insulin sensitivity. Observations noted that it also tended to prevent weight gain or even facilitate weight loss. Trials carried out have positively enforced this in obese patients as well as those with Polycystic Ovary Syndrome.We were interested to see if a similar favourable effect coul...

ea0005p230 | Steroids | BES2003

Beneficial affects of regular exercise: Is it all in the hormones?

Andrews R , Wood P

Background: Diabetes increases the risk of developing coronary heart disease irrespective of glycaemic control. Cortisol and growth hormone (GH) abnormalities have been found in these patients and have been proposed as possible mechanisms for this increased risk.Regular exercise, through an unknown mechanism, can modify cardiovascular risk and so prevent or delay the progression of coronary heart disease. In this study we assessed whether an exercise program would a...

ea0004s4 | (1) | SFE2002

Steroidogenic Factor-1: A Pivotal Regulator of Gonadotroph Gene Expression


The glycoprotein hormone common alpha-subunit (alphaGSU) is an early endocrine marker of pituitary development and is expressed concurrently with the orphan nuclear receptor, steroidogenic factor-1 (SF-1). Our studies have examined the potential role of SF-1 in alphaGSU gene expression using two gonadotroph-derived cell lines as models of the developing pituitary.We investigated the role of SF-1 and its binding site, the gonadotroph-specific element (GSE...

ea0004oc10 | Endocrine tumours and neoplasia | SFE2002

The Role of Insulin-Like Growth Factor II and its Intracellular Mediators in the Control of Chicken Ovarian Functions

Sirotkin A , Grossman R

In our in-vitro experiments we examined the involvement of insulin-like growth factor type II (IGF-II) in the control of ovarian function in domestic fowl, together with the intracellular mechanisms of IGF-II action. Fragments of ovarian follicles were cultured with and without IGF-II (1-100 ng/ml), blockers of protein kinase A (PAK, KT5820, 10 mg/ml), tyrosine kinase (TK, AG1024, 1mg/ml), mitogen-activated protein konase (MAPK, PD98059, 10 mg/ml), cyclin-dependent protein kin...

ea0004p9 | Clinical case reports | SFE2002


Bennett S , Quinton R

We present a case of acquired hypogonadotrophic hypogonadism (HH) in a 54-year-old man that illustrates the need for wider endocrine screening in such patients. Having undergone complete pubertal development as a teenager and subsequently fathered two children, the patient presented with a nine-month history of reduced libido, erectile dysfunction, hot sweats and headaches. His GP had diagnosed HH on the basis of a low testosterone with inappropriately low gonadotrophins. Exam...

ea0004ds8 | Treatment of insulin resistance or post-prandial hyperglycaemia - contrasting evidence | SFE2002

The Role of Metformin

Holman R , Stratton I

The UKPDS trial confirmed that improving glycaemic control (median 0.9 % HbA1c difference over median 10 years), with sulphonylurea or insulin therapy, could reduce significantly the risk of microvascular complications (25%, p=0.0099) and was associated with a 16% trend (p=0.052) to a reduced risk of coronary heart disease (CHD). In overweight UKPDS patients allocated metformin as first line therapy the 0.6% median HbA1c difference obtained was associated...

ea0003s4 | British Thyroid Association - Pitt-Rivers Lecture | BES2002

Molecular genetics of congential hypothyroidism

Di|#Lauro R

Congenital hypothyroidism (CH) is one of the most frequent congenital diseases. In 85% of cases, this condition is due to thyroid dysgenesis (TD) whose phenotype - thyroid absent or ectopically located and/or severely reduced in size - clearly represent disturbances during gland organogenesis. Some years ago we discovered that three transcription factors, TTF-1, TTF-2 and Pax-8, are expressed not only in mature thyroid cells but also in their precursors. Work in animal models ...

ea0003s4biog | British Thyroid Association - Pitt-Rivers Lecture | BES2002

British Thyroid Association - Pitt-Rivers Lecture

Di Lauro R

Roberto Di Lauro, School of Medicine of the University of Naples 'Federico II', Naples, Italy AbstractRoberto Di Lauro is Professor of Human Genetics at the School of Medicine of the University of Naples 'Federico II'. He is also responsible for the Laboratory of Biochemistry and Molecular Biology at the Stazione Zoologica 'Anton Dohrn' (Naples). He was visiting associate from 1974 to 1978 and visiting scientist from 1...

ea0003s27 | Cell Based Therapies for Treating Neuroendocrine Disease | BES2002

Human neural stem cells: A therapeutic modality for neurodegenerative disease

Caldwell M , Burnstein R

Neurodegenerative diseases are characterised by the loss of specific subsets of neurons, and whilst drug therapies exist for some of these disorders (eg Parkinson's disease) none of them are curative. This has led to the search for a cell-based therapy, the most successful being the transplantation of human fetal tissue into Parkinson's patients. However, there are ethical and logistical problems associated with this tissue collection, hence an alternative source has been soug...

ea0003p129 | Endocrine Tumours and Neoplasia | BES2002

Hypercalcaemia associated with clear cell carcinoma of the ovary

Haq M , Simpson R

A 74 year old female presented with symptoms of recent fatigue, nausea and weight loss. No other symptoms were present. She had previously had a hysterectomy with conservation of both ovaries 30 years previously for fibroids. The rest of her history was unremarkable. No undue clinical findings were apparent on examination. Initial bloods revealed normal haematology, biochemistry and liver profiles. Corrected calcium was elevated at 3.07 millimoles per litre(2.1-2.6). Subsequen...