Endocrine Abstracts

Congenital hypothyroidism (CH) is one of the most frequent congenital diseases. In 85% of cases, this condition is due to thyroid dysgenesis (TD) whose phenotype - thyroid absent or ectopically located and/or severely reduced in size - clearly represent disturbances during gland organogenesis. Some years ago we discovered that three transcription factors, TTF-1, TTF-2 and Pax-8, are expressed not only in mature thyroid cells but also in their precursors. Work in animal models ...

Roberto Di Lauro, School of Medicine of the University of Naples 'Federico II', Naples, Italy AbstractRoberto Di Lauro is Professor of Human Genetics at the School of Medicine of the University of Naples 'Federico II'. He is also responsible for the Laboratory of Biochemistry and Molecular Biology at the Stazione Zoologica 'Anton Dohrn' (Naples). He was visiting associate from 1974 to 1978 and visiting scientist from 1...