Searchable abstracts of presentations at key conferences in endocrinology

ea0027s6 | CME Session | BSPED2011

T2DM

Ehtisham S

Abstract unavailable....

ea0026s1.1 | Keep cool, lose weight: brown fat and energy metabolism | ECE2011

Brown adipocytes and energy homeostasis in mice

Herzig S

Adipose tissue can be subdivided into two distinct categories of fat cells: white adipocytes are specialized for the storage of chemical energy such as triglycerides, and under conditions of obesity white adipose tissue is characterized by tissue inflammation and energy overload.In contrast, brown adipocytes dissipate energy in the form of heat (thermogenesis) by uncoupling of the mitochondrial electron transport chain from ATP formation through the spec...

ea0025s3.2 | Fat endocrinology: disorders of adipose tissue and lipids important to the endocrinologist | SFEBES2011

Familial partial lipodystrophy: an introduction and the importance of diagnosing FPLD

Suliman S

Lipodystrophy including familial, acquired and secondary forms displays the full spectrum of the metabolic syndrome including severe insulin resistance, hyperinsulinaemia; hypertension, hypertriglyceridaemia, low HDL cholesterol, and hyperglycaemia1. This group have an absolute or partial reduction in fat mass, yet often show more extreme metabolic features than obese individuals.Partial lipodystrophy may be genetic or acquired. Genetic causes...

ea0025cm1.1 | The management of difficult Graves’ disease | SFEBES2011

Autoimmune hyperthyroidism: a spectrum of causes

Pearce S

Autoimmune hyperthyroidism has a complex aetiology including both environmental and inherited components. Amongst the environmental factors that are well documented to be important are smoking and stressful life events. The prevalence of all forms of autoimmune hyperthyroidism is known to be higher in women, but the effects of oestrogen are complex: the combined oral contraceptive pill protecting against Graves’ disease, whereas pregnancy predisposes. Autoimmune hyperthyr...

ea0025cm2.1 | Endocrine problems in pregnancy | SFEBES2011

Hypothyroidism and euthyroid antibody-positivity in pregnancy

Chan S

Overt hypothyroidism, diagnosed and treated with L-thyroxine pre-pregnancy, affects 1% of pregnancies. Untreated maternal hypothyroidism is associated with adverse obstetric and neonatal outcomes, and even when partially treated the risks of miscarriage and prematurity remain elevated compared to euthyroidism. With increased understanding of the normal physiological changes to thyroid function during pregnancy, there should be a predictive approach to thyroxine ...